Category: 3840-31-1

Electric Literature of 3840-31-1 ,Some common heterocyclic compound, 3840-31-1, molecular formula is C10H14O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To 3.5 g (53 mmol) of 85% potassiumhydroxide was added a solution of 10 g (50.5 mmol) ofalcohol 8 in 40 mL of DMSO, and the mixture washeated at 50-70 while stirring till the dissolution ofK, then the heating was switched off. On coolingthe mixture to room temperature a solution of 7 g(56.9 mmol) of allyl bromide in 10 mL of DMSO wasadded, and the mixture was stirred for 16 h. Then themixture was heated (5060) at stirring till thecompletion of the reaction (5 h). The mixture wasdiluted with 200 mL of water, the reaction product wasextracted into ethyl acetate (4 × 50 mL). The organicphase was washed with water, dried with Na2SO4, thesolvent was distilled off, the residue was dried in avacuum.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3840-31-1, (3,4,5-Trimethoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Potapov; Panov; Musalov; Zhivet?eva; Musalova; Khabibulina; Amosova; Russian Journal of Organic Chemistry; vol. 52; 11; (2016); p. 1571 – 1575; Zh. Org. Khim.; vol. 52; 11; (2016); p. 1579 – 1583,5;,
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Related Products of 3840-31-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of commercially available (3,4,5-trimethoxyphenyl)methanol (25 g, 126 mmol) in THF (150 mL) was added sodium hydride (3.93 g, 164 mmol) portion-wise at 0 C and the reaction mixture was stirred at 0 C (10 minutes). Iodomethane (10.2 mL, 164 mmol) was then added drop-wise and the resulting mixture was allowed to come to room temperature with stirring (3 h). The reaction was quenched by pouring into ice, extracted (EtOAc), washed with brine, dried (Na2SO4), filtered and concentrated and the resulting residue was purified by silica gel column chromatography to provide 6f as a colorless oil (26.44 g, 125 mmol, 99 % yield).

According to the analysis of related databases, 3840-31-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Zhao, Xue Zhi; Maddali, Kasthuraiah; Smith, Steven J.; Metifiot, Mathieu; Johnson, Barry C.; Marchand, Christophe; Hughes, Stephen H.; Pommier, Yves; Burke Jr., Terrence R.; Bioorganic and Medicinal Chemistry Letters; vol. 22; 24; (2012); p. 7309 – 7313;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C10H14O4

20 mg of Au-Co composite particle load (0.1 mol%), 13.8 mg K2CO3 (10 mol%), 198.0 mg 3,4,5-trimethoxybenzyl alcohol (1 mmol), 4 mL of methanol was sequentially added to a pressure vessel with a 25 mL glass lining. After replacing the oxygen three times, the pressure was increased to 0.1 MPa, and the reaction was carried out at 80 C for 12 h, and cooled to room temperature. The gas is depressurized, the catalyst is filtered, the filtrate is concentrated by rotary evaporation, and the residue is subjected to column chromatography.White solid productMethyl 3,4,5-trimethoxybenzoate 169.5 mg,The yield was 78%.

With the rapid development of chemical substances, we look forward to future research findings about 3840-31-1.

Reference:
Patent; Dalian Institute of Chemical Physics; Gao Shuang; Li Guosong; Lv Ying; (9 pag.)CN109824513; (2019); A;,
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Alcohols – Chemistry LibreTexts

Related Products of 3840-31-1 ,Some common heterocyclic compound, 3840-31-1, molecular formula is C10H14O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a 25-mL Schlenk tube equipped with a magnetic stirrer, CuCl (0.05 mol, 5 mol%), DABCO (0.10 mol, 10 mol%), 4-HO-TEMPO (0.05 mmol, 5 mol%) were added. Substrates 1 (1 mmol) and NH3 (aq, 25-28%, 3 mmol, 3.0 equiv) in CH3CN (2 mL) were added subsequently. Then the reaction mixture was stirred at room temperature for 24 h in the presence of an air balloon. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4. Subsequently, the combined organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography to afford the corresponding products.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3840-31-1, (3,4,5-Trimethoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hu, Yongke; Chen, Lei; Li, Bindong; Chinese Chemical Letters; vol. 29; 3; (2018); p. 464 – 466;,
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Related Products of 3840-31-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3840-31-1 as follows.

A solution of alcohol 30?22 (396 mg, 2 mmol), imidazole (300 mg, 4.4mmol), and TBSCl (332 mg, 2.2 mmol) in anhyd CH2Cl2 (4 mL) was stirred at overnight at`1234/7458-+ * r.t. H2O (5 mL) and CH2Cl2 (20 mL) were addedto the mixture, and the organic layer was separated, washed successivelywith sat. aq NaHCO3 (5 mL), H2O (2 × 5 mL), and brine (5 mL),then dried (MgSO4) and filtered. The filtrate was concentrated in vacuoand the residue was purified by flash column chromatography [silicagel, EtOAc-PE (1:25)] to give a colorless oil; yield: 569 mg (91%).IR (KBr): 2962, 2928, 2857, 1596, 1499, 1459, 1378, 1017, 832, 775cm-1.1H NMR (300 MHz, CDCl3): delta = 6.57 (s, 2 H), 4.69 (s, 2 H), 3.85 (s, 6 H),3.83 (s, 3 H), 0.96 (s, 9 H), 0.11 (s, 6 H).13C NMR (75 MHz, CDCl3): delta = 153.16, 137.14, 136.78, 102.80, 64.86,60.78, 55.96, 25.89, 18.36, -5.28.MS (ESI, MeOH): m/z = 335 [M + Na]+.HRMS-ESI: m/z [M + Na]+ calcd for C16H28NaO4Si: 335.1655; found:335.1663.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3840-31-1, its application will become more common.

Reference:
Article; Zhang, Qi; Kang, Xiuqin; Long, Lei; Zhu, Lijuan; Chai, Yonghai; Synthesis; vol. 47; 1; (2015); p. 55 – 64;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C10H14O4

A mixture of 15 g (75.76 mmol) of alcohol 8,7.5 g (113.6 mmol) of 85% potassium hydroxide, and120 mL of DMSO was heated at 110-120 in arotating pressure reactor of 1 liter capacity at acetylenepressure of 1012 atm for 5 h. The mixture was dilutedwith 300 mL of water, the reaction product wasextracted into ethyl acetate (4 × 50 mL). The organic phase was washed with water, dried with Na2SO4, thesolvent was distilled off. To purify the residue it waspassed through a small bed of alkaline alumina (eluentether). Yield 15.45 g (91%), yellowish liquid. 1 NMRspectrum, delta, ppm: 3.73 s (3, OCH3), 3.75 s (6,OCH3), 4.00 d (1, =CH2, 3J 6.8 Hz), 4.22 d (1,=CH2, 3J 14.3 Hz), 4.58 s (2, OCH2), 6.456.52 m (3,=CH, Carom). 13 NMR spectrum, delta, ppm: 55.75(OCH3), 60.05 (OCH3), 69.95 (OCH2), 87.22 (=CH2),106.81 (Carom), 132.32 (Carom), 138.16 (Carom),151.61 (=CH), 153.51 (Carom). Found, %: 64.54; 7.35. C12H16O4. Calculated, %: 64.27; 7.19.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3840-31-1, (3,4,5-Trimethoxyphenyl)methanol.

Reference:
Article; Potapov; Panov; Musalov; Zhivet?eva; Musalova; Khabibulina; Amosova; Russian Journal of Organic Chemistry; vol. 52; 11; (2016); p. 1571 – 1575; Zh. Org. Khim.; vol. 52; 11; (2016); p. 1579 – 1583,5;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 3840-31-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3840-31-1 as follows.

The reactants used are 3,4,5-trimethoxybenzyl alcohol (i.e., R1 in formula (I) is 3, 4, 5 and 3Oxy) 1.0 mmol (198.2 mg), the experimental procedure and procedure were the same as in Example 1, aqueous ammonia (1.8 mol / L)The amount of catalyst used in cuprous bromide is5 mol% (7.2 mg), the amount of TEMPO was 5 mol% (7.8 mg), the reaction temperature was 100 C,The reaction time was 20 h and the crude product was purified by column chromatography (petroleum ether: ethyl acetate = 10: 1) to give pure target product with 185.5 mg yield of 96%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3840-31-1, its application will become more common.

Reference:
Patent; Zhejiang University of Technology; Zhang Guofu; Zhao Yiyong; Zhang Guihua; Ding Chengrong; Yu Yidong; Lv Jinghui; (10 pag.)CN106866326; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 3840-31-1, (3,4,5-Trimethoxyphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (3,4,5-Trimethoxyphenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (3,4,5-Trimethoxyphenyl)methanol

i 3,4,5-Trimethoxybenzyl chloride In 40 ml of benzene was dissolved 10 g of 3,4,5-trimethoxybenzyl alcohol. To the resulting solution was dropwise added under chilling with ice 10 ml of benzene solution containing 7.6 g of thionyl chloride. After the addition was complete, the mixture was stirred at room temperature for 15 min. The reaction solution was poured into a chilled aqueous potassium carbonate, and a separated benzene portion was collected. The benzene portion was washed with a saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and placed under reduced pressure to distill off the solvent. The desired compound was obtained as a yellow solid (yield: 11.0 g).

The synthetic route of 3840-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nippon Chemiphar Co., Ltd.; US5070089; (1991); A;,
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Reference of 3840-31-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol. A new synthetic method of this compound is introduced below.

General procedure: The compound (3,4,5-trimethoxyphenyl)-methanol 15 (4.5 mmol) was dissolved in THF (15 mL) and added to a stirred suspension of NaH (60%, 5.4 mmol) in THF (5 mL) at 0 C. The reaction mixture was stirred for 30 min at the same temperature. Propargyl bromide (4.9 mmol) was added to the reaction mixture at the same temperature and stirring was continued for an additional 5 h at room temperature. After completion the reaction (TLC), the reaction mixture was quenched with ice water and extract with ethyl acetate (2 * 20 mL). The organic extract was washed with brine, dried over Na2SO4, and solvent removed under reduced pressure. The residue was subjected to silica gel column chromatography purification (ethyl acetate/hexane 1:10) to afford 1,2,3-trimethoxy-5-((prop-2-yn-1-yloxy)methyl)benzene 16.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3840-31-1, (3,4,5-Trimethoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Suman; Murthy, T. Ramalinga; Rajkumar; Srikanth; Dayakar; Kishor, Chandan; Addlagatta, Anthony; Kalivendi, Shasi V.; Raju, B. China; European Journal of Medicinal Chemistry; vol. 90; (2015); p. 603 – 619;,
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Alcohols – Chemistry LibreTexts

Related Products of 3840-31-1, Adding some certain compound to certain chemical reactions, such as: 3840-31-1, name is (3,4,5-Trimethoxyphenyl)methanol,molecular formula is C10H14O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3840-31-1.

To the solution of 3,4,5-trimethoxybenzyl alcohol (7.2 g, 36.4 mol) in dry DCM (100 mL), thionyl chloride (3.5 mL, 48.2 mmol) and pyridine (3.4 mL, 42.1 mmol) were added dropwise. The reaction mixture was stirred at RT for 1.5 h and progress was monitored by TLC (AcOEt/Hex 1:1 as mobile phase). The reaction was stopped by the addition of 100 mL H2O and extracted with 2 x 25 mL DCM. The combined organic extracts were dried over MgSO4 and evaporated in vacuo to give 87% yield. Yellow, solid.

According to the analysis of related databases, 3840-31-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Urbaniak, Alicja; Delgado, Magdalena; Kacprzak, Karol; Chambers, Timothy C.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 12; (2017); p. 2766 – 2770;,
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