Related Products of 3840-31-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3840-31-1 as follows.
A solution of alcohol 30?22 (396 mg, 2 mmol), imidazole (300 mg, 4.4mmol), and TBSCl (332 mg, 2.2 mmol) in anhyd CH2Cl2 (4 mL) was stirred at overnight at`1234/7458-+ * r.t. H2O (5 mL) and CH2Cl2 (20 mL) were addedto the mixture, and the organic layer was separated, washed successivelywith sat. aq NaHCO3 (5 mL), H2O (2 × 5 mL), and brine (5 mL),then dried (MgSO4) and filtered. The filtrate was concentrated in vacuoand the residue was purified by flash column chromatography [silicagel, EtOAc-PE (1:25)] to give a colorless oil; yield: 569 mg (91%).IR (KBr): 2962, 2928, 2857, 1596, 1499, 1459, 1378, 1017, 832, 775cm-1.1H NMR (300 MHz, CDCl3): delta = 6.57 (s, 2 H), 4.69 (s, 2 H), 3.85 (s, 6 H),3.83 (s, 3 H), 0.96 (s, 9 H), 0.11 (s, 6 H).13C NMR (75 MHz, CDCl3): delta = 153.16, 137.14, 136.78, 102.80, 64.86,60.78, 55.96, 25.89, 18.36, -5.28.MS (ESI, MeOH): m/z = 335 [M + Na]+.HRMS-ESI: m/z [M + Na]+ calcd for C16H28NaO4Si: 335.1655; found:335.1663.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3840-31-1, its application will become more common.
Reference:
Article; Zhang, Qi; Kang, Xiuqin; Long, Lei; Zhu, Lijuan; Chai, Yonghai; Synthesis; vol. 47; 1; (2015); p. 55 – 64;,
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