Category: 78573-45-2

Synthetic Route of 78573-45-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, molecular weight is 204.19, as common compound, the synthetic route is as follows.

10 kg of dichloromethane was added to a 50 L reactor, and 3-(3-trifluoromethylphenyl)propanol (1 kg, 4.90 mol) and triethylamine (0.59 kg, 5.88 mol) were added in sequence with stirring. The jar was rinsed with 3 kg of dichloromethane. Cool down to -5-10 C, Methanesulfonyl chloride (0.62 kg, 5.39 mol) was slowly added dropwise. The temperature of the reaction system was maintained at -5 to 10 C, and the addition was completed at about 50 to 80 minutes. The incubation was continued until the TLC monitoring reaction was complete and the reaction was completed in about 1 h. 10 kg of water was added under stirring, stirring was continued for 20 min, and the layers were allowed to stand. The organic phase was retained, and the aqueous phase was further extracted with 11 kg of dichloromethane. The organic phase was combined and the aqueous phase was discarded. The organic phase was transferred to a 50 L reactor, cooled to 5-10 C, 10 kg of water was added, stirred for 30 min, allowed to stand for stratification, and the aqueous phase was discarded; the organic phase was washed with 10 kg of 10% NaCl solution, allowed to stand for stratification, and the water phase was discarded. go with. The organic phase was dried over 0.50 kg anhydrous magnesium sulfate and stirred for about 1 h. The magnesium sulfate was filtered off, the reaction kettle was rinsed with 2 kg of dichloromethane and the filter cake was washed, and the organic phases were combined. Transfer the organic phase to the concentrator, Concentrated under reduced pressure to give a yellow oily liquid 1.41kg. HPLC purity: 98.58%.

The chemical industry reduces the impact on the environment during synthesis 78573-45-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Jiangsu Yong’an Pharmaceutical Co., Ltd.; Luo Huan; Kang Yanlong; Li Qian; Qiu Chunfang; Liu Kelei; Wang Shuaiwei; (8 pag.)CN109096119; (2018); A;,
Alcohol – Wikipedia,
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Reference of 78573-45-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, molecular weight is 204.19, as common compound, the synthetic route is as follows.

In a 500 ml reaction flask, 15 g of m-trifluoromethylbenzenepropanol,8.2 g of triethylamine and 150 ml of methylene chloride was added, stirred and cooled down to -5 C. Methanesulfonyl chloride (10 g of methanesulfonyl chloride + 30 ml of methylene chloride) was added dropwise and the temperature was controlled at -5 C. for about 0.5 hour. 1 hour. Plus 8.2g triethylamine, the control temperature -5 , the reaction 0.5 hours. 100 ml of ice water was added and the mixture was stirred for 10 minutes. The layers were separated and the organic layer was separated. The aqueous layer was extracted once with 100 ml of dichloromethane. The organic layers were combined, washed once with 100 ml of saturated sodium chloride solution and dried over 20 g of anhydrous sodium sulfate for 2 hours. The sodium sulfate was filtered off and concentrated under reduced pressure until no fractions were distilled off. 100 ml of isopropyl acetate was added to dissolve and concentrated under reduced pressure No distillate distillate, the product, yield 97.9%, purity 99.5% (W / W).

Statistics shows that 78573-45-2 is playing an increasingly important role. we look forward to future research findings about 3-(3-(Trifluoromethyl)phenyl)propan-1-ol.

Reference:
Patent; Shandong Xinhua Pharmaceutical Co., Ltd.; He Xinheng; Zheng Zhonghui; Jiang Tao; He Weihao; Jiang Zeyu; (5 pag.)CN107473993; (2017); A;,
Alcohol – Wikipedia,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, molecular weight is 204.19, as common compound, the synthetic route is as follows.Safety of 3-(3-(Trifluoromethyl)phenyl)propan-1-ol

Example 2 Synthesis of 3-[3-(trifluoromethyl)phenyl]-propionaldehyde (II) A solution of compound (V) (1.0 g, 4.90 mmol) in dichloromethane (20 ml) is cooled in water/ice bath, treated in succession with DMSO (770 mg, 9.80 mmol) and P2O5 (1.39 g, 9.80 mmol) and left under stirring for 30 minutes, while temperature raises to 20 C. The reaction mixture is then cooled in water/ice bath and triethylamine (2.4 ml, 17.15 mmol). The resulting solution is kept under stirring while temperature raises to 20 C. After one hour the mixture is treated with 5% HCl, the phases are separated and the organic one is further washed with 5% HCl. The organic phase is then washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure, to afford 0.99 g of the aldehyde of formula (II) in quantitative yield. 1H NMR (300 MHz, CDCl3), ppm: 9.83 (t, 1H, J 0.9 Hz), 7.48-7.38 (m, 4H), 3.02 (t, 2H, J 7.2 Hz), 2.82 (m, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, and friends who are interested can also refer to it.

Reference:
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Related Products of 78573-45-2, Adding some certain compound to certain chemical reactions, such as: 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol,molecular formula is C10H11F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 78573-45-2.

A solution of (R) -N- [1- (1-naphthyl) ethyl] -2-nitrobenzenesulfonamide in toluene (83 g pure)92 g of triphenylphosphine,72 g of 3- (3-trifluoromethylphenyl) propanol and 125 mL of toluene were added and stirred. Adjust the solution temperature to 50 ° C,DiisopropylazodicarboxylateA diluted solution obtained by adding 330 mL of toluene to 71 g was dropped. After the dripping end50 mL of toluene was added and stirred at 50 ° C. for 1 hour.After completion of the reaction, 133 g of anhydrous magnesium chloride and 42 mL of toluene were added. After stirring at 50 ° C. for 2 hours, the liquid temperature was cooled to 0 ° C.The reaction solution was filtered to remove insolubles, and then washed with 415 mL of toluene cooled to 0° 415 mL of tap water was added to the filtrate and stirred, and the aqueous layer was removed by liquid separation operation. The same operation was repeated twice, and the obtained organic layer was concentrated under reduced pressure at 55 ° C. to 1165 mL,(R) -N- [1- (1-naphthyl) ethyl] -3- [3- (trifluoromethyl) phenyl]Propane-2-nitrobenzenesulfonamide tolueneA solution was obtained (pure yield 127 g, pure yield 100percent, chemical purity 92percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Iwaki Pharmaceutical Co Ltd; Nagasaki, Atsushi; Fukushima, Koichi; (8 pag.)JP2019/14687; (2019); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 3-(3-(Trifluoromethyl)phenyl)propan-1-ol

2.51 g (14.7 mmol) of (R)-1-(1-naphthyl)-ethylamine and 3.01 g (14.7 mmol) of 3-[3-(trifluoromethyl)phenyljpropanol are weight into a flask. The mixture is diluted with 6 ml of toluene and 53 mg (0.45 mol percent) of {IrCp*Cl2]2 is added. The mixture is heated in a bath at t=110 °C under a reflux condenser in the nitrogen atmosphere for 20 hours. After cooling down, the reaction mixture is diluted with a mixture of hexane and ethyl acetate. On addition of a solution of hydrogen chloride in diethylether, a solid salt is formed and by sucking it off 4.83 g (83 percent) of Cinacalcet hydrochloride is obtained in a purity of 97.8 percent (HPLC). The method described in Example 1 was used for HPLC determination.

With the rapid development of chemical substances, we look forward to future research findings about 78573-45-2.

Reference:
Patent; ZENTIVA, K.S.; VLASAKOVA Ruzena; HAJICEK Josef; WO2013/75679; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C10H11F3O, blongs to alcohols-buliding-blocks compound. Computed Properties of C10H11F3O

Example 20; [00088] 3.0 g of crude material of compound V were dissolved in DCM (60 ml). TEA (5.6 ml) was added followed by drop-wise addition of Methanesulfonyl chloride (1.2 ml) at room temperature. The reaction mixture was stirred at room temperature for 2 hours. Then the reaction mixture was poured into crushed ice (98 g) and INHCl (30 ml). DCM (30 ml) was added to the mixture. Phase separation was done and the aqueous phase was extracted with DCM (30 ml) once again. The organic phase was EPO dried over Sodium sulfate and the solvent was evaporated under vacuum to give 3.39 g of the compound VI.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES, LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2006/125026; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 78573-45-2

(12-2) Synthesis of 1-(3-bromopropyl)-3-trifluoromethylbenzene (compound 12-2) Compound 12-1 (9.00 g) was dissolved in methylene chloride (80 ml), triphenylphosphine (12.8 g) and N-bromosuccinimide (8.63 g) were added under ice-cooling, and the mixture was stirred under ice-cooling for 1 hr, and further at room temperature for 3 hr. The reaction mixture was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. Diethyl ether (200 ml) was added, and the precipitated triphenylphosphine oxide was filtered off. The concentrate of the filtrate was purified by silica gel column chromatography (hexane alone) to give the object product (8.59 g) as a colorless oil. 1H-NMR(CDCl3) delta (ppm): 2.17-2.23(2H, m), 2.85(2H, t, J=7.5Hz), 3.40(2H, t, J=6.4Hz), 7.38-7.49(4H, m).

With the rapid development of chemical substances, we look forward to future research findings about 78573-45-2.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2168944; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 78573-45-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 78573-45-2 as follows.

(e) p-Toluenesulfonic acid [3-(3-trifluoromethylphenyl)propyl] ester 125 g of p-toluenesulfonic acid [3-(3-trifluoromethylphenyl)propyl] ester are obtained as a yellow oil from 71.5 g of 3-(3-trifluoromethylphenyl)propan-1-ol, 83 g of p-toluenesulfonic acid chloride and 54 ml of pyridine in 160 ml of chloroform by the procedure described in Example 5e.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,78573-45-2, its application will become more common.

Reference:
Patent; BYK Gulden Lomberg Chemische Fabrik Gesellschaft mit beschrankter Haftung; US4324796; (1982); A;,
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Alcohols – Chemistry LibreTexts

Reference of 78573-45-2 ,Some common heterocyclic compound, 78573-45-2, molecular formula is C10H11F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

At room temperature, 15 ml of CHCl,3g 3- (3-trifluoromethylphenyl) propanol was added to a 100 ml reaction flaskA, 2.2 g of triethylamine, stirred and dissolved, and dropwise 2 g of methanesulfonyl chloride. After completion of the dropwise addition, the reaction was carried out for 2 to 3 hours The reaction kettle by adding 9ml 1mol / l of dilute hydrochloric acid stirring, liquid separation. Add 9ml 5% NaHCO3 solution to wash the organic phase, stir Mix and disperse. The organic phase was washed with 9 ml of 25% NaCl, stirred and partitioned. Add anhydrous Na2SO4 to dry and filter. stress reliever The product was distilled to give 5.5 g of a pale yellow liquid in 100% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 78573-45-2, 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Qing Song Pharmaceutical Co., Ltd.; Zhang, Jian; Chen, Xiaona; Zhang, Shubin; Gao, Junfeng; Tan, Zhouhong; (7 pag.)CN106543008; (2017); A;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. 78573-45-2

Step 3: Preparation of Compound III (i.e., 3-(3-trifluoromethylphenyl)propanal) To a solution of 10 g (48 mmol) of Compound VII, 76.6 mg of TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy free radical) and 234 mg of potassium bromide in 70 mL methylene chloride was added 220 mL (pH=9.5) of sodium hypochlorite solution over 20 minutes at 10-15 C. with stirring. After five minutes of additional stirring, the organic layer was separated. The aqueous layer was extracted twice with 40 mL of methylene chloride, and the collected organic layers were dried and evaporated to yield 10 g of crude Compound III as a yellowish liquid. Yield: 100%; purity (determined by GC): 90.3%, contains 8.25% of Compound NMR data (200 MHz, CDCl3, ppm): 2.81 (t, 2H), 3.00 (t, 21-1), 7.37-7.46 (m, 4H), 9.80 (s, 1H).

Statistics shows that 78573-45-2 is playing an increasingly important role. we look forward to future research findings about 3-(3-(Trifluoromethyl)phenyl)propan-1-ol.

Reference:
Patent; Medichem, S.A.; US2010/267988; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts