Reference of 78573-45-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.78573-45-2, name is 3-(3-(Trifluoromethyl)phenyl)propan-1-ol, molecular formula is C10H11F3O, molecular weight is 204.19, as common compound, the synthetic route is as follows.
In a 500 ml reaction flask, 15 g of m-trifluoromethylbenzenepropanol,8.2 g of triethylamine and 150 ml of methylene chloride was added, stirred and cooled down to -5 C. Methanesulfonyl chloride (10 g of methanesulfonyl chloride + 30 ml of methylene chloride) was added dropwise and the temperature was controlled at -5 C. for about 0.5 hour. 1 hour. Plus 8.2g triethylamine, the control temperature -5 , the reaction 0.5 hours. 100 ml of ice water was added and the mixture was stirred for 10 minutes. The layers were separated and the organic layer was separated. The aqueous layer was extracted once with 100 ml of dichloromethane. The organic layers were combined, washed once with 100 ml of saturated sodium chloride solution and dried over 20 g of anhydrous sodium sulfate for 2 hours. The sodium sulfate was filtered off and concentrated under reduced pressure until no fractions were distilled off. 100 ml of isopropyl acetate was added to dissolve and concentrated under reduced pressure No distillate distillate, the product, yield 97.9%, purity 99.5% (W / W).
Statistics shows that 78573-45-2 is playing an increasingly important role. we look forward to future research findings about 3-(3-(Trifluoromethyl)phenyl)propan-1-ol.
Reference:
Patent; Shandong Xinhua Pharmaceutical Co., Ltd.; He Xinheng; Zheng Zhonghui; Jiang Tao; He Weihao; Jiang Zeyu; (5 pag.)CN107473993; (2017); A;,
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