Category: 440-60-8

Application of 440-60-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 440-60-8, name is (Perfluorophenyl)methanol, molecular formula is C7H3F5O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(a) 2,2-Dimethyl-3-dichlorovinyl-cyclopropanecarboxylic acid pentafluorobenzyl ester STR28 0.1 mole of 2,2-dimethyl-3-dichlorovinyl-cyclopropanecarboxylic acid chloride (cis/trans) was added dropwise at 70 C. to 0.1 mole of pentafluorobenzyl alcohol. The mixture was then heated at 120 C. for a few minutes until gas evolution ceased. The yield of an oil, which was pure by thin-layer chromatography, was quantitative. b.p.0.1 120-130 C. Spectroscopic data: IR (cm-1): 2,900, 1,740, 1,660, 1,510, 1,460, 1,415, 1,385, 1,355, 1,310, 1,220, 1,161, 1,130, 1,080, 1,050, 995, 970, 940, 810, 780. mass spectrum (m/e): 181, 163, 165, 91, 127, 109, 191, 207, 353, 388 (M). NMR (ppm): 6.6 and 5.6 d (1), 5.2 s (2), 0.8-2.4 m (8).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 440-60-8, (Perfluorophenyl)methanol.

Reference:
Patent; Bayer Aktiengesellschaft; US4183950; (1980); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 440-60-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 440-60-8, name is (Perfluorophenyl)methanol. A new synthetic method of this compound is introduced below.

Example 10 In a 30 ml two-necked flask were added 0.004 g of LiOH.H2O, 0.31 g of methyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate, 1.00 g of (2,3,4,5,6-pentafluorophenyl)methyl alcohol and 0.6 g of toluene, and the mixture was stirred for 8 hours at a toluene refluxing temperature. Analysis of the reaction mixture by a gas chromatography showed that the yield of (2,3,4,5,6-pentafluorophenyl)methyl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate was 92% based on the starting ester.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,440-60-8, (Perfluorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Sumitomo Chemical Company, Limited; US6441220; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 440-60-8, name is (Perfluorophenyl)methanol. A new synthetic method of this compound is introduced below., Recommanded Product: (Perfluorophenyl)methanol

General procedure: To 100 mg compound 2 (0.54 mmol) suspended in 5 mL CH2Cl2 was added 0.5 mL oxalyl chloride (0.27 mmol) slowly. The mixturewas reacted under room temperature for 1 h. Solvent was distilled under reduced pressure, residue dissolved in 2 mL CH2Cl2 and dropwised to a mixture containing 0.6 mmol relevant ROH, 1.8 mmol triethylamine and 5 mL CH2Cl2. The mixture was reacted underroom temperature and monitored by TLC to the end of reaction, solvent distilled, residue recrystallization from ethyl acetate and hexane affords target compounds.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 440-60-8, (Perfluorophenyl)methanol.

Reference:
Article; Du, Qing-Shan; Shi, Yan-Xia; Li, Peng-Fei; Zhao, Zhen-Jiang; Zhu, Wei-Ping; Qian, Xu-Hong; Li, Bao-Ju; Xu, Yu-Fang; Chinese Chemical Letters; vol. 24; 11; (2013); p. 967 – 969;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 440-60-8, Adding some certain compound to certain chemical reactions, such as: 440-60-8, name is (Perfluorophenyl)methanol,molecular formula is C7H3F5O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 440-60-8.

General rocedure: 5.5 ml of aq. solutions of KBr (0.55 mol/dm3), 20 ml MeCN, TEMPO (0.12 g, 0.00077 mol), and 2,2,3-trifluoro-3-(1,1,2,2,3,3-hexafluoro-3-trifluoromethoxy-propoxy)-propan-1-ol (2a) (10 g, 0.0275 mol) were placed in the flask. 14% aq. NaOCl (48 ml) buffered by NaHCO3 (5.2 g) were added via the dropping funnel in 3 portions during two days of stirring in a room temperature (slight exothermic effect). The progress of reaction was monitored by 19F NMR spectroscopy. Then concentrated sulfuric acid followed by water was added. After extraction with diethyl ether, the organic phases were dried over magnesium sulfate. The solvent was evaporated to give a colorless liquid, which was distilled.

According to the analysis of related databases, 440-60-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ignatowska, Jolanta; Shyshkov, Oleg; Zipplies, Tilman; Hintzer, Klaus; Roeschenthaler, Gerd-Volker; Journal of Fluorine Chemistry; vol. 141; (2012); p. 35 – 40;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 440-60-8, name is (Perfluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. name: (Perfluorophenyl)methanol

Example 11 In a 30 ml two-necked flask were added 0.004 g of LeOH.H2O, 0.40 g of methyl 2,2-dimethyl-3-(2,2-dichlorovinyl)cyclopropanecarboxylate, 1.00 g of (2,3,4,5,6-pentafluorophenyl)methyl alcohol and 0.8 g of toluene, and the mixture was stirred for 8 hours at a toluene refluxing temperature. Analysis of the reaction mixture by a gas chromatography showed that the yield of (2,3,4,5,6-pentafluorophenyl)methyl 2,2-dimethyl-3-(2,2-dichlorovinyl)-cyclopropanecarboxylate was 84% based on the starting ester.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 440-60-8, (Perfluorophenyl)methanol.

Reference:
Patent; Sumitomo Chemical Company, Limited; US6441220; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 440-60-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 440-60-8, name is (Perfluorophenyl)methanol, molecular formula is C7H3F5O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

At 100mL2.95g (25mmol) of 2,3,4,5,6-pentafluorobenzyl alcohol was added to the three-necked flask.Triethylamine 2.5g,Toluene 40mL,Slow dropCis-2,2-dimethyl-3-(E/Z-2-chloropropenyl)cyclopropanecarboxylic acid chloride 6g (29mmol),The reaction was carried out at room temperature for 4 hours.The organic phase is sequentially 20mL5% sodium hydroxide solution,Wash with 5% hydrochloric acid solution and saturated sodium chloride solution, dry,After desolvation, a pale yellow viscous liquid is obtained.After column chromatography (petroleum ether / ethyl acetate = 20/1), 9.0 g of pale yellow liquid was obtained.The yield was 96%.

According to the analysis of related databases, 440-60-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mt. Huang College; Han Bingbing; Zheng Zubiao; (15 pag.)CN109776327; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

440-60-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 440-60-8, name is (Perfluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

(a) Pentafluorobenzyl Fluoride A mixture of pentafluorobenzyl alcohol (3.0 g) and dry methylene dichloride (50 ml) was cooled to a temperature of 0 C. in an ice-bath and 2-chloro-1-diethylamino-1,1,2-trifluoroethane (4.3 g) was slowly added to the cooled, stirred mixture over a period of ten minutes. After standing for a period of 18 hr. at 0 C. the reaction mixture was poured into ice and the organic layer was separated and washed with IM aqueous sodium carbonate solution. The organic layer was dried over anhydrous sodium sulfate, the solvent was removed by distillation and the product was distilled under reduced pressure to give pentafluorobenzyl fluoride, b.p. 51 C. at 30 mm Hg.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 440-60-8, (Perfluorophenyl)methanol.

Reference:
Patent; ICI Australia Limited; US4283414; (1981); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 440-60-8, (Perfluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 440-60-8, blongs to alcohols-buliding-blocks compound. 440-60-8

EXAMPLE 1 This Example illustrates the preparation of 2-methyl-3,4,5,6-tetrafluorobenzyl alcohol. A solution of methyl bromide (9.6 g) in dry tetrahydrofuran (25 cm3) was added dropwise in a stirred mixture of magnesium turnings (5.0 g), dry tetrahydrofuran (50 cm3) and a small crystal of iodine at the ambient temperature (ca. 22 C.). When the addition was complete the mixture was stirred for a further 1 hour at the ambient temperature and the solution of methyl magnesium bromide thus formed was then added dropwise to a stirred solution to pentafluorobenzyl alcohol (17.8 g) in tetrahydrofuran (50 cm3) whilst the temperature was maintained at 30 C. When the addition was complete the mixture was stirred for a further 2 hours at the ambient temperature and for 3 hours at the reflux temperature. Water at 0 C. was added to the mixture, which was then acidified with dilute hydrochloric acid and extracted with diethyl ether (2*80 cm3). The extracts were combined, washed with water, dried over anhydrous magnesium sulphate and concentrated by evaporation of the solvent under reduced pressure. The residual oil (4.6 g) was shown by gas liquid chromatographic examination of a sample to consist of ca. 70% by weight of unreacted starting material and ca. 30% by weight of product. The oil was subjected to vigorous purification by column and thin-layer chromatography using a silica gel support and eluding with a mixture of diethyl ether and hexane (3:7 by volume), to obtain 2-methyl-3,4,5,6-tetrafluorobenzyl alcohol as a colourless oil. 1 H nmr (CDCl3) delta: 1.86 (broad s,1H); 2.35 (q,3H); 4.74 (d,2H). 19 F nmr (CDCl3) delta: -142.3 (dd, J=12.6, 21Hz); -145.9 (dd, J=12.6, 21Hz); -157.25 (t,J=21Hz); -160.5 (t,J=21Hz);

With the rapid development of chemical substances, we look forward to future research findings about 440-60-8.

Reference:
Patent; Imperial Chemical Industries PLC; US4714790; (1987); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

440-60-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.440-60-8, name is (Perfluorophenyl)methanol, molecular formula is C7H3F5O, molecular weight is 198.09, as common compound, the synthetic route is as follows.

General procedure: Liquid-phaseoxidation of 1-phenylethanol was performed in glass flaskequipped with a magnetic stirrer, reflux condenser, andthermometer. In a typical experiment, a mixture of the1-phenylethanol (2mmol), toluene (10 mL), and the catalyst(0.3 g) was transferred in a glass three-necked roundbottomedflask (100 mL); the resulting mixture was thenheated to desired temperature with vigorous stirring. Theoxidation experiment was started by bubbling oxygen gas ata flow rate of 20 mL/min into the reaction mixture. After thereaction, the solid catalyst was filtered off by centrifugationand the liquid productswere analyzed by gas chromatographyto determine the conversion of the alcohol and productselectivity by GC, 7890A,Agilent Technologies Inc., equippedwith a flame ionization detector (FID) and a 19019S-001 HPPONAcolumn.

Statistics shows that 440-60-8 is playing an increasingly important role. we look forward to future research findings about (Perfluorophenyl)methanol.

Reference:
Article; Assal, Mohamed E.; Kuniyil, Mufsir; Shaik, Mohammed Rafi; Khan, Mujeeb; Al-Warthan, Abdulrahman; Siddiqui, Mohammed Rafiq H.; Adil, Syed Farooq; Journal of Chemistry; vol. 2017; (2017);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

440-60-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 440-60-8 as follows.

In a 10 mL round bottom flask, 0.99 g of pentafluorobenzyl alcohol and 2 g of diethylene glycol dimethyl ether were sequentially added.The resulting mixture was subjected to ultrasonic irradiation at 40 kHz/30 W/70 C for 30 minutes in an ultrasonic reaction apparatus. The diethylene glycol dimethyl ether was removed under reduced pressure, and recrystallized to obtain 0.89 g of pentafluorobenzoic acid in a yield of 95%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,440-60-8, its application will become more common.

Reference:
Patent; Central South University; Xiao Fang; Xiao Yuanyuan; Zeng Ming; Li Na; Yin Lirong; (15 pag.)CN108467342; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts