Category: 306281-86-7

On March 14, 2019, Ashcraft, Luke; Boezio, Alessandro; Butler, John; Chandra, Aroop; Chuang, Chihyuan; Collibee, Scott E.; Debenedetto, Mikkel; Dimassa, Vincent; Graceffa, Russell; Malinowski, Justin; Moebius, David; Morgan, Bradley P.; Payette, Joshua; Romero, Antonio; St. Jean, David, Jr.; Vargas, Richard; Yeoman, John; Zhang, Hanmo published a patent.Application of 306281-86-7 The title of the patent was Bisamides as cardiac sarcomere modulators and their preparation. And the patent contained the following:

The invention provides a compound of formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof. Compounds of formula I wherein Q is (un)substituted aryl, (un)substituted sulfonylpyrrolidinyl, (un)substituted 5- to 6-membered heteroaryl, etc.; X1 is N and CR2; X2, X3, X4 and X5 are independently N and CR3, provided at 0, 1 or 2 of X1 – X5 are N and the remaining are CR2 and CR3; R1a is H, C1-6 alkyl and halo; R1 is H, C1-6 alkyl, C1-6 alkenyl, C2-6 alkynyl, etc.; R2 is H, halo, C1-6 alkyl, C1-6 haloalkyl, etc.; R1R2 can be taken together to form (CH2)1-3, OCH2, CH2OCH2, etc.; R3 is H, halo, C1-6 alkyl, SF5, etc.; R13a is H and C1-6 alkyl; R13 and R14 are independently C1-6 alkyl, C3-7 cycloalkyl, and C3-7 cycloalkyl-C1-6 alkyl; R13R14 can be taken together to form (un)fused (un)saturated 4- to 7-membered heterocyclyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by amidation of (R)-1-((S)-1-((3-cyanoazetidin-1-yl)sulfonyl)piperidine-3-carbonyl)pyrrolidine-2-carboxylic acid with benzylamine. The invention compounds were evaluated for their cardiac sarcomere modulatory activity (some data given). The experimental process involved the reaction of (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol(cas: 306281-86-7).Application of 306281-86-7

The Article related to bisamide preparation sarcomere modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 306281-86-7

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On December 14, 2020, Zhang, Jiandong; Yang, Xiaoxiao; Dong, Rui; Gao, Lili; Li, Jing; Li, Xing; Huang, Shuangping; Zhang, Chaofeng; Chang, Honghong published an article.COA of Formula: C9H10F3NO The title of the article was Cascade biocatalysis for regio- and stereoselective aminohydroxylation of styrenyl olefins to enantiopure arylglycinols. And the article contained the following:

Chiral β-amino alcs. are privileged scaffolds frequently found in pharmaceutically active mols. and natural products. Aminohydroxylation of olefins is one of the most powerful strategies to access chiral vicinal amino alcs. However, the direct regio- and stereoselective aminohydroxylation of olefins to unprotected enantioenriched β-amino alcs. remains a long-standing challenge. Herein, we report that a novel one-pot four-enzyme [styrene monooxygenase (SMO)/epoxide hydrolase (EH)/alc. dehydrogenase (ADH)/ω-transaminase (TA)] biocatalytic cascade efficiently catalyzes the direct transformation of readily available styrenyl olefins into unprotected 2-amino-2-Ph ethanols in good yields and excellent enantioselectivity. In vitro cascade biocatalysis aminohydroxylation of styrenyl olefins was first investigated by the combined four enzymes (SMO/EH/ADH/TA) with a trace amount of NADH (0.02 mM) and pyridoxal-5′-phosphate (0.1 mM), affording both enantiomers of β-amino alcs. 5a-j in 13.9-98.7% conversions and 86-99% ee. Whole-cell-based cascade biocatalysis was achieved by using the constructed recombinant Escherichia coli pairwise combinations and single tailor-made whole-cell biocatalyst without an addnl. NADH cofactor; (R)- and (S)-β-amino alcs. 5a-j could be obtained in 14.6-99.7% conversions and 86-99% ee. Moreover, the preparative experiments of this new cascade biocatalysis were demonstrated by the single tailor-made whole-cell biocatalyst [E. coli (CGS-DEM) and E. coli (CGS-DEB)] with the substrates 1a-b and 1h in an aqueous-organic two-phase system, affording chiral β-amino alcs. [(R)- or (S)-5a-b, h] in good yields (50.9-64.3%) and excellent ee (>99%). A new type of cascade biocatalysis was developed for regio- and enantioselective aminohydroxylation of styrenyl olefins to useful and valuable chiral arylglycinols in good yields and excellent ee. The experimental process involved the reaction of (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol(cas: 306281-86-7).COA of Formula: C9H10F3NO

The Article related to cascade reaction stereoselective aminohydroxylation styrenyl olefin arylglycinol, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.COA of Formula: C9H10F3NO

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On October 16, 2006, Kato, Keisuke; Matsuba, Chie; Kusakabe, Taichi; Takayama, Hiroyuki; Yamamura, Shigeo; Mochida, Tomoyuki; Akita, Hiroyuki; Peganova, Tat’yana A.; Vologdin, Nikolai V.; Gusev, Oleg V. published an article.Category: alcohols-buliding-blocks The title of the article was 2,2′-Isopropylidenebis[(4S,5R)-4,5-di(2-naphthyl)-2-oxazoline] ligand for asymmetric cyclization-carbonylation of meso-2-alkyl-2-propargylcyclohexane-1,3-diols. And the article contained the following:

The oxidative cyclization-carbonylation of meso-2-alkyl-2-propargylcyclohexane-1,3-diols I (R = Me, n-Pr, H2C:CHCH2) mediated by Pd(II) with chiral bisoxazoline (box ligand) afforded bicyclic β-alkoxyacrylates II. Based on a ligand screening, 2,2′-isopropylidenebis[(4S,5R)-4,5-di(2-naphthyl)-2-oxazoline] ligand has been developed. The products II with a chiral quaternary carbon were obtained in 71-100% yields with 85-95% ee. The experimental process involved the reaction of (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol(cas: 306281-86-7).Category: alcohols-buliding-blocks

The Article related to benzofuran perhydro carboxymethylene asym synthesis, cyclohexanediol propargyl preparation enantioselective cyclization carbonylation oxazoline palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Category: alcohols-buliding-blocks

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On September 30, 2000, Hirose, Keiji; Ogasahara, Kazuko; Nishioka, Kazuyuki; Tobe, Yoshito; Naemura, Koichiro published an article.Name: (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol The title of the article was Enantioselective complexation of phenolic crown ethers with chiral aminoethanol derivatives: effects of substituents of aromatic rings of hosts and guests on complexation. And the article contained the following:

Optically active azophenolic crown ethers having Ph groups substituted at the resp. para-position were prepared and their association constants with chiral aminoethanol derivatives, including 2-amino-2-phenylethanols having an electron-donating or an electron-withdrawing group, were determined in chloroform by means of UV-vis titration methods. The enantioselectivities of these crown ethers are estimated from the ratio of the association constants KR/KS and the effect of aromatic substituents of both hosts and guests on the binding abilities and enantioselectivities is discussed. The structures of the complexes were investigated on the basis of the 1H NMR and UV-vis spectra. The experimental process involved the reaction of (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol(cas: 306281-86-7).Name: (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol

The Article related to enantioselective complexation phenolic crown ether chiral aminoethanol substituent effect, Physical Organic Chemistry: Other Reactions, Processes, and Spectra and other aspects.Name: (R)-2-Amino-2-(4-(trifluoromethyl)phenyl)ethanol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts