4048-33-3 Archives - Alcohols-buliding-blocks

Liu, Bin’s team published research in Chem in 2019 | CAS: 4048-33-3

6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Safety of 6-Aminohexan-1-ol

Safety of 6-Aminohexan-1-olIn 2019 ,《Three-Component Sequential Reactions for Polymeric Nanoparticles with Tailorable Core and Surface Functionalities》 appeared in Chem. The author of the article were Liu, Bin; Thayumanavan, S.. The article conveys some information:

Efficient strategies for the preparation of nanostructures with tailorable functionalities have implications in enhancing the repertoire of nanomaterials in many applications. Multi-component reactions (MCRs) are very attractive because they are synthetically simple while providing unique access to incorporation of functional groups onto a system. This highly efficient process has not been brought to bear in the preparation of functional polymeric nanostructures. In this paper, we report a three-component sequential reaction that is capable of concurrently functionalizing the core and the surface of the nanoparticles and crosslinking the polymeric assemblies, along with excellent control over size (~10 nm to ~1μm). Variations in core offer the opportunity to optimize the host-guest properties for non-covalent drug encapsulation, while the surface features provide the ability to tune interfacial interactions and achieve organelle targeting in cells. Encapsulation of drug mols. and their triggered release features have been utilized for intracellular drug delivery. In the experiment, the researchers used 6-Aminohexan-1-ol(cas: 4048-33-3Safety of 6-Aminohexan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Cheng’s team published research in Carbon in 2021 | CAS: 4048-33-3

6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Computed Properties of C6H15NO

Chen, Cheng; Wang, Zhi-Qin; Gong, Yan-Yan; Wang, Ji-Chao; Yuan, Ye; Cheng, Hua; Sang, Wei; Chaemchuen, Somboon; Verpoort, Francis published their research in Carbon in 2021. The article was titled 《Cobalt embedded in nitrogen-doped porous carbon as a robust heterogeneous catalyst for the atom-economic alcohol dehydrogenation to carboxylic acids》.Computed Properties of C6H15NO The article contains the following contents:

Herein, cobalt embedded in nitrogen-doped porous carbon (Co@NC) was developed as a robust heterogeneous catalyst for the dehydrogenative coupling of primary alcs. and hydroxides. With Co@NC as the first earth-abundant metal/carbon composite material for this transformation, numerous aromatic and aliphatic carboxylic acids were efficiently afforded. Notably, the newly prepared Co@NC was fabricated in a facile and straightforward manner and reused up to 15 recycle rounds without activity decay. It is also worth emphasizing that the catalyst recycling was realized via magnetic separation with no special treatment or activation. Addnl., further experiments elucidated the pivotal role of the cobalt and nitrogen elements dispersed in the carbon matrix as well as the hierarchical porosity (micro-/meso-pores) in the catalytic activity and recyclability. Considering the active sites of Co@NC, we envisioned that the Co-N species was the most active site, while other active sites such as Co-O, Co0 species and free N-doped carbon were also present, but demonstrating lower activity or stability in comparison with the Co-N species. Addnl. mechanistic investigations were carried out to gain more insights into the possible reaction pathways. We found that the aldehyde was identified as a crucial intermediate, and two possible pathways were proposed for this catalytic process. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Computed Properties of C6H15NO)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Duo’s team published research in ChemCatChem in 2020 | CAS: 4048-33-3

《Iron-catalyzed hydrosilylation of diacids in the presence of amines: a new route to cyclic amines》 was published in ChemCatChem in 2020. These research results belong to Wei, Duo; Netkaew, Chakkrit; Wu, Jiajun; Darcel, Christophe. Application of 4048-33-3 The article mentions the following:

Herein, a novel chemoselective strategy for building N-substituted cyclic amines I (n = 1, 2, 3; R = H, 4-Me; R1 = cyclohexyl, 1-(naphthalen-1-yl)ethyl, 2H-1,3-benzodioxol-5-yl, etc.) and 2-(4-methoxyphenyl)-2,3,3a,4,7,7a-hexahydro-1H-isoindole via iron catalyzed one-pot hydrosilylation starting from readily available dicarboxylic acids e.g., pentanedioic acid and amines R1NH2, with hydrosilanes as the hydride sources was presented. The described methodol. allows the preparation of a wide range of N-alkylated and arylated cyclic amine derivatives I (including pharmaceuticals Fenpiprane and Prozapine) in moderate to excellent yields, starting from inexpensive succinic, glutaric, and adipic acids with di-Me carbonate as a green solvent. In the experimental materials used by the author, we found 6-Aminohexan-1-ol(cas: 4048-33-3Application of 4048-33-3)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Chien-Hsin’s team published research in Polymer in 2020 | CAS: 4048-33-3

Synthetic Route of C6H15NOIn 2020 ,《Size-dependent phase separation and thermomechanical properties of thermoplastic polyurethanes》 was published in Polymer. The article was written by Wu, Chien-Hsin; Huang, Ying-Chi; Chen, Wei-Lun; Lin, Yen-Yu; Dai, Shenghong A.; Tung, Shih-Huang; Jeng, Ru-Jong. The article contains the following contents:

Over the years, the manipulation of polymer microphase separation associated with mol. architectures has been holding great promise for rendering structure-property relationship. A series of poly (urea/malonamide) dendrons bearing rigid adamantanes in the periphery were developed to serve as branching hard segments (HS) for thermoplastic polyurethanes (TPUs) either in end-capping or pendant manner. Thermal properties, crystalline structures, and mech. properties of the TPUs were investigated by DSC, X-ray scattering, and DMA, resp. The introduction of the branching units with bulky adamantanes would expectedly hinder the crystallization of HS. Intriguingly, the dendrons not only accelerate the crystallization of the soft segment (SS, based on polycaprolactone polyol (PCL)), but promote the phase separation between HS and SS to form distinct microdomains as well. These enhanced effects revealed a size-dependent relationship with growing size (or generation) of the branching HS. With the high SS crystallinity that can freeze the chain mobility and the robust HS domains that work as the phys. crosslinking points, the resulting TPUs incorporated with adamantane-bearing units show superior shape memory behaviors. This work demonstrates that the mol. engineering on the architectures can significantly tailor the microstructures and properties of thermal plastic polymers. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Synthetic Route of C6H15NO)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiang, Jian-Qiao’s team published research in iScience in 2019 | CAS: 4048-33-3

The author of 《Dendron-functionalized surface: Efficient strategy for enhancing the capture of microvesicles》 were Jiang, Jian-Qiao; Chanseau, Christel; Alves, Isabel D.; Nlate, Sylvain; Durrieu, Marie-Christine. And the article was published in iScience in 2019. Product Details of 4048-33-3 The author mentioned the following in the article:

Microvesicles (MVs) are used by various types of cells in the human body for intercellular communication, making them biomarkers of great potential for the early and non-evasive diagnosis of a spectrum of diseases. An integrated anal. including morphol., quant., and compositional studies is most desirable for the clin. application of MV detection; however, such integration is limited by the currently available anal. techniques. In this context, exploiting the phosphatidylserine (PS) exposure of MVs, we synthesized a series of dendritic mols. with PS-binding sites at the periphery. PS-dendron binding was studied at the mol. level using NMR approaches, whereas PS-containing membrane-dendron interaction was investigated in an aqueous environment using plasmon waveguide resonance spectroscopy. As a proof of concept, polyethylene terephthalate surface was functionalized with the synthetic dendrons, forming devices that can capture MVs to facilitate their subsequent analyses. The experimental part of the paper was very detailed, including the reaction process of 6-Aminohexan-1-ol(cas: 4048-33-3Product Details of 4048-33-3)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Wan-Qiang’s team published research in Catalysts in 2020 | CAS: 4048-33-3

《Highly efficient N-heterocyclic carbene/ruthenium catalytic systems for the acceptorless dehydrogenation of alcohols to carboxylic acids: effects of ancillary and additional ligands》 was written by Wang, Wan-Qiang; Cheng, Hua; Yuan, Ye; He, Yu-Qing; Wang, Hua-Jing; Wang, Zhi-Qin; Sang, Wei; Chen, Cheng; Verpoort, Francis. SDS of cas: 4048-33-3 And the article was included in Catalysts in 2020. The article conveys some information:

The transition-metal-catalyzed alc. dehydrogenation to carboxylic acids has been identified as an atom-economical and attractive process. Among various catalytic systems, Ru-based systems have been the most accessed and investigated ones. With our growing interest in the discovery of new Ru catalysts comprising N-heterocyclic carbene (NHC) ligands for the dehydrogenative reactions of alcs., we designed and prepared five NHC/Ru complexes ([Ru]-1-[Ru]-5) bearing different ancillary NHC ligands. Moreover, the effects of ancillary and addnl. ligands on the alc. dehydrogenation with KOH were thoroughly explored, followed by the screening of other parameters. Accordingly, a highly active catalytic system, which is composed of [Ru]-5 combined with an addnl. NHC precursor L5, was discovered, affording a variety of acid products in a highly efficient manner. Gratifyingly, an extremely low Ru loading (125 ppm) and the maximum TOF value until now (4800) were obtained. In the experiment, the researchers used 6-Aminohexan-1-ol(cas: 4048-33-3SDS of cas: 4048-33-3)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Marchesi, Elena’s team published research in Molecules in 2021 | CAS: 4048-33-3

Marchesi, Elena; Bovolenta, Matteo; Preti, Lorenzo; Capobianco, Massimo L.; Mamchaoui, Kamel; Bertoldo, Monica; Perrone, Daniela published an article in 2021. The article was titled 《Synthesis and Exon-Skipping Properties of a 3′-Ursodeoxycholic Acid-Conjugated Oligonucleotide Targeting DMD Pre-mRNA: Pre-Synthetic versus Post-Synthetic Approach》, and you may find the article in Molecules.Computed Properties of C6H15NO The information in the text is summarized as follows:

Steric blocking antisense oligonucleotides (ASO) are promising tools for splice modulation such as exon-skipping, although their therapeutic effect may be compromised by insufficient delivery. To address this issue, we investigated the synthesis of a 20-mer 2′-OMe PS oligonucleotide conjugated at 3′-end with ursodeoxycholic acid (UDCA) involved in the targeting of human DMD exon 51, by exploiting both a pre-synthetic and a solution phase approach. The two approaches have been compared. Both strategies successfully provided the desired ASO 51 3′-UDC in good yield and purity. It should be pointed out that the pre-synthetic approach insured better yields and proved to be more cost-effective. The exon skipping efficiency of the conjugated oligonucleotide was evaluated in myogenic cell lines and compared to that of unconjugated one: a better performance was determined for ASO 51 3′-UDC with an average 9.5-fold increase with respect to ASO 51. In the part of experimental materials, we found many familiar compounds, such as 6-Aminohexan-1-ol(cas: 4048-33-3Computed Properties of C6H15NO)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Zhou’s team published research in CCS Chemistry in 2022 | CAS: 4048-33-3

In 2022,Zhang, Zhou; Han, Faming; Fang, Jie; Zhao, Chaowei; Li, Shuai; Wu, Yonggang; Zhang, Yuefeng; You, Shengyong; Wu, Binghui; Li, Weiwei published an article in CCS Chemistry. The title of the article was 《An organic-inorganic hybrid material based on benzo[ghi]perylenetri-imide and cyclic titanium-oxo cluster for efficient perovskite and organic solar cells》.Synthetic Route of C6H15NO The author mentioned the following in the article:

Perovskite and organic solar cells usually require electron-transport interlayers to efficiently transport electrons from the photoactive layer to the metal electrode. In general, pure organic or inorganic materials are applied into the interlayers, but organic-inorganic hybrid materials have been rarely reported for this application. In this work, we report using the first titanium-oxo cluster-based organic-inorganic hybrid as the interlayer material by introducing large π-conjugated benzo[ghi]perylenetriimides as an organic part via a simple ligand-exchange reaction. This new hybrid material showed excellent solubility, well-aligned energy levels, and excellent electron mobilities, enabling its great potential application as an interlayer in solar cells such as perovskite and organic solar cells, providing high power conversion efficiencies of >20% and 16%, resp. Therefore, we claim that our present work introduces a new class of cluster-based organic-inorganic hybrid interlayer materials that exhibit promising application in organic electronics. The results came from multiple reactions, including the reaction of 6-Aminohexan-1-ol(cas: 4048-33-3Synthetic Route of C6H15NO)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kabiri, Yoones’s team published research in ChemBioChem in 2019 | CAS: 4048-33-3

In 2019,ChemBioChem included an article by Kabiri, Yoones; Angelin, Alessandro; Ahmed, Ishtiaq; Mutlu, Hatice; Bauer, Jens; Niemeyer, Christof M.; Zandbergen, Henny; Dekker, Cees. HPLC of Formula: 4048-33-3. The article was titled 《Intercalating Electron Dyes for TEM Visualization of DNA at the Single-Molecule Level》. The information in the text is summarized as follows:

Staining compounds containing heavy elements (electron dyes) can facilitate the visualization of DNA and related biomols. by using TEM. However, research into the synthesis and utilization of alternative electron dyes has been limited. Here, we report the synthesis of a novel DNA intercalator mol., bis-acridine uranyl (BAU). NMR spectroscopy and MS confirmed the validity of the synthetic strategy and gel electrophoresis verified the binding of BAU to DNA. For TEM imaging of DNA, two-dimensional DNA origami nanostructures were used as a robust microscopy test object. By using scanning transmission electron microscopy (STEM) imaging, which is favored over conventional wide-field TEM for improved contrast, and therefore, quant. image anal., it is found that the synthesized BAU intercalator can render DNA visible, even at the single-mol. scale. For comparison, other staining compounds with a purported affinity towards DNA, such as dichloroplatinum, cisplatin, osmium tetroxide, and uranyl acetate, have been evaluated. The STEM contrast is discussed in terms of the DNA-dye association constants, number of dye mols. bound per base pair, and the electron-scattering capacity of the metal-containing ligands. These findings pave the way for the future development of electron dyes with specific DNA-binding motifs for high-resolution TEM imaging. In addition to this study using 6-Aminohexan-1-ol, there are many other studies that have used 6-Aminohexan-1-ol(cas: 4048-33-3HPLC of Formula: 4048-33-3) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lucas, Sebastian’s team published research in Solar RRL in 2021 | CAS: 4048-33-3

Lucas, Sebastian; Kammerer, Jochen; Pfannmoeller, Martin; Schroeder, Rasmus R.; He, Yakun; Li, Ning; Brabec, Christoph J.; Leydecker, Tim; Samori, Paolo; Marszalek, Tomasz; Pisula, Wojchiech; Mena-Osteritz, Elena; Baeuerle, Peter published their research in Solar RRL in 2021. The article was titled ãMolecular Donor-Acceptor Dyads for Efficient Single-Material Organic Solar Cellsã?Application of 4048-33-3 The article contains the following contents:

Single-material organic solar cells (SMOSCs) promise several advantages with respect to prospective applications in printed large-area solar foils. Only one photoactive material has to be processed and the impressive thermal and photochem. long-term stability of the devices is achieved. Herein, a novel structural design of oligomeric donor-acceptor (D-A) dyads 1-3 is established, in which an oligothiophene donor and fullerene acceptor are covalently linked by a flexible spacer of variable length. Favorable optoelectronic, charge transport, and self-organization properties of the D-A dyads are the basis for reaching power conversion efficiencies up to 4.26% in SMOSCs. The dependence of photovoltaic and charge transport parameters in these ambipolar semiconductors on the specific mol. structure is investigated before and after post-treatment by solvent vapor annealing. The inner nanomorphol. of the photoactive films of the dyads is analyzed with transmission electron microscopy (TEM) and grazing-incidence wide-angle X-ray scattering (GIWAXS). Combined theor. calculations result in a lamellar supramol. order of the dyads with a D-A phase separation smaller than 2 nm. The mol. design and the precise distance between donor and acceptor moieties ensure the fundamental phys. processes operative in organic solar cells and provide stabilization of D-A interfaces. The experimental part of the paper was very detailed, including the reaction process of 6-Aminohexan-1-ol(cas: 4048-33-3Application of 4048-33-3)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts