Category: 1875-89-4

Adding a certain compound to certain chemical reactions, such as: 1875-89-4, 2-(m-Tolyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C9H12O, blongs to alcohols-buliding-blocks compound. Formula: C9H12O

Example 8-2- [2- (3-methylphenyl) ethoxy]-2′, 3′, 5-TRI-O-(TERT- butyldimethylsilyl)-adenosine [54] To a dry 250-mL, 3-neck roundbottom flask was added 2-chloro- 2′, 3′, 5-TRI-O-(TERT-BUTYLDIMETHYLSILYL) adenosine (5 g, 7.8 mmol, Example 1) and 2- (3-methylphenyl) ethanol (15 mL). The mixture was flushed with nitrogen for 5-10 minutes, then heated to 50 °C. To this mixture was added sodium hydride (1.56 g, 39 mmol, as a 60percent dispersion in mineral oil) at such a rate as to avoid excessive gas evolution. The reaction was maintained at 50 °C until the predominant component was the product by HPLC (partially deprotected products were also seen). The reaction was then cooled to room temperature, carefully quenched with water (40 mL), and extracted with ethyl acetate (3 x 100 mL). The combined organic extracts were washed with brine (120 mL), dried (MGS04), filtered, and concentrated under reduced pressure to afford a brown oil. This material was purified by passing through a plug of silica gel, eluting with CH2CL2, 5percent methanol in CHSCIS, and 10percent methanol in CH2CL2. Those fractions containing products were combined and evaporated to dryness, to afford a mixture of starting material and monosilyl-protected and disilyl-protected alkylated products in a ratio of 2: 5: 12.This mixture was used without further purification in the next step

The synthetic route of 1875-89-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC.; WO2005/33121; (2005); A2;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1875-89-4, name is 2-(m-Tolyl)ethanol, the common compound, a new synthetic route is introduced below. name: 2-(m-Tolyl)ethanol

Part A. Preparation of 3-methylphenethyl bromide. To a solution of 3-methylphenethyl alcohol (5.0 g, 36.7 mmol) in methylene chloride at 0° C. was added triphenylphosphine (10.6 g, 40.4 mmol) and carbon tetrabromide (13.4 g, 40.4 mmol). The mixture was allowed to stir with warming to 25° C. for 16 h. The solvent was removed in vacuo and the residue was taken up in ether and filtered through a pad of silica gel. The solvent was removed in vacuo to afford 7.0 g (95percent) of the title bromide.

The synthetic route of 1875-89-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DuPont Pharmaceuticals Company; US6060462; (2000); A;,
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Related Products of 1875-89-4 , The common heterocyclic compound, 1875-89-4, name is 2-(m-Tolyl)ethanol, molecular formula is C9H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 306: 2-[1-(4-Chlorophenylsulfonyl)-3-(3-methylphenyl)propyl]-1,4-difluorobenzene In a similar manner to Example 304 except for the use of 2-(3-methylphenyl)ethanol (90.0 mul, 0.661 mmol), the title compound (115 mg, 0.273 mmol, 83percent) was obtained as colorless plate crystals.1H-NMR (400 MHz, CDCl3) delta: 2.29(3H,s), 2.35-2.48(2H,m), 2.56-2.64(1H,m), 2.68-2.77(1H,m), 4.46-4.49(1H,m), 6.83-6.88(3H,m), 6.97-7.03(2H,m), 7.14(1H,t,J=7.8Hz), 7.26(1H,ddd,J=8.7,5.4,3.3Hz), 7.36(2H,d,J=8.6Hz), 7.49(2H,d,J=8.6Hz). IR (ATR) cm-1: 3072, 2969, 1581, 1496, 1475, 1423, 1394, 1319, 1276, 1211, 1147, 1081, 1012. mp: 87-88°C. MS m/z: 421 (M++H).Anal. calcd for C22H19ClF2O2S: C, 62.78; H, 4.55; Cl, 8.42; F, 9.03; S, 7.62. Found: C, 62.58; H, 4.60; Cl, 8.49; F, 9.21; S, 7.77.

The synthetic route of 1875-89-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1466898; (2004); A1;,
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Alcohols – Chemistry LibreTexts

Reference of 1875-89-4, Adding some certain compound to certain chemical reactions, such as: 1875-89-4, name is 2-(m-Tolyl)ethanol,molecular formula is C9H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1875-89-4.

General procedure: The alcohol (1.0 eq) was added to a suspension of Dess-Martin periodinane (1.2 eq) in CH2Cl2(100 mM) under an argon atmosphere at room temperature. The mixture was allowed to stir for0.5 – 20 hours, while consumption of starting material was monitored by TLC. After the reactionwas complete, 1M Na2S2O3 (equal volume to CH2Cl2) was added. After stirring for 15 minutes,the phases were separated and the aqueous phase was extracted with CH2Cl2 twice. Thecombined organic layers were washed with 5% NaHCO3 and brine, and dried over Na2SO4. Thesolvent was evaporated under reduced pressure and the residue was purified by columnchromatography to afford analytically pure aldehydes.b) alcohol precursors for aldehydes 13, 14, 20 (solid alcohols)The alcohol (1.0 eq) was dissolved in CH2Cl2 (200 mM) and the solution was added to asuspension of Dess-Martin periodinane (1.2 eq) in CH2Cl2 (200 mM) under an argon atmosphereat room temperature. The mixture was allowed to stir for 0.5 – 20 hours (TLC monitoring). Then,Et2O (equal volume to CH2Cl2), 1M Na2S2O3 and saturated NaHCO3 (both equal volume toCH2Cl2) were added. After stirring for 15 minutes, the phases were separated and the aqueousphase was extracted with Et2O twice. The combined organic layers were washed with sat.NaHCO3 and brine, and dried over Na2SO4. The solvent was evaporated under reduced pressureand the residue was purified by column chromatography to afford analytically pure aldehydes.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1875-89-4, 2-(m-Tolyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ruff, Bettina M.; Bra?se; O’Connor, Sarah E.; Tetrahedron Letters; vol. 53; 9; (2012); p. 1071 – 1074;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1875-89-4, name is 2-(m-Tolyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C9H12O

3-methyl phenethyl alcohol (5 g, 36.7 MMOL) was diluted in 30 mL of chloroform and ammonium nitrate (3.12 g, 38.9 MMOL) was added. The reaction mixture was cooled to 0 °C and trifluor acetic acid anhydride (16.02 mL, 113 MMOL) was added dropwise. The reaction stirred at 0 °C for 3 hours before water was added to slowly quench the reaction. The chloroform layer was washed with water then collected and dried over NA2SO4 then concentrated. The desired isomer crystallized out of the crude solution in ethyl acetate and was then triturated with acetonitrile to afford 5.25 g of the desired isomer as a brown solid. Yield 87percent; MS (APCI) : 199 [M-H]-.

With the rapid development of chemical substances, we look forward to future research findings about 1875-89-4.

Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/41793; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 1875-89-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1875-89-4, name is 2-(m-Tolyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 97 5-{(2R)-2-[(2R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid bis-(2-m-tolyl-ethyl) ester hydrochloride salt The title compound was prepared as a brown oil from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 2-(3-methylphenyl)ethanol according to the procedure of Example 1; yield: 81percent; 1 H NMR (300 MHz, CDCl3): delta 1.12 (m, J=6.3 Hz, 3H),2.27 (s, 6H), 2.79 (m, 7H), 3.19 (m, 1H), 3.48 (m, 2H), 4.29 (m, J=6.6 Hz, 4H), 5.49 (m, 1H,) 6.75 (m, J=8.1 Hz, 1H), 6.83 (m, 1H), 7.05 (m, 8H), 7.20 (m, 1H), 7.27 (m, 1H), 7.43 (s, 1H), 7.5 (m, 2H); MS (ES) m/z (relative intensity): 658 (M+ +H, 100).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1875-89-4, 2-(m-Tolyl)ethanol.

Reference:
Patent; American Home Products Corporation; US5914339; (1999); A;,
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Alcohols – Chemistry LibreTexts

Related Products of 1875-89-4, Adding some certain compound to certain chemical reactions, such as: 1875-89-4, name is 2-(m-Tolyl)ethanol,molecular formula is C9H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1875-89-4.

Example 3:; 3-(lH-Indol-2-ylV4-(2-m-tolyl-ethoxyMH-pyridin-2-one; a) 2-[2-Methoxy-4-(2-m-tolyl-ethoxy)-pyridin-3-yl]-lH-indole; A mixture of 2-(4-iodo-2-methoxy-pyridin-3-yl)-lH-indole (20 mg, 57 mumol), copper iodide (1.09 mg, 5.7 mumol), 1,10-phenanthroline (2.0 mg, 11.4 mumol) and cesium carbonate (37 mg, 11.4 mumol) are suspended in 2-m-tolylethanol (85 mul, 0.62 mmol) under inert gas atmosphere in a sealed tube which is heated at 110 0C for 24 hours. The reaction mixture is treated with ethyl acetate (10 ml), water (10 ml) and cone, aqueous ammonia (100 mul). The phases are separated, worked up and extracted with ethyl acetate. The product is purified by preparative chromatography. Yield: 10 mg (47 percent).1H-NMR (400 MHz, D6-DMSO): delta= 10.82 (br, IH), 8.05 (d, IH), 7.49 (d, IH), 7.42 (d, IH), 7.15 – 7.05 (m, 4H), 7.01 – 6.94 (m, 3H), 6.67 (s, IH), 4.37 (t, 2H), 3.93 (s, 3H), 3.05 (t, 2H), 2.16 (s, 3H)MS: M = 359.12 (ESI+)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1875-89-4, 2-(m-Tolyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/25526; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 1875-89-4, 2-(m-Tolyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-(m-Tolyl)ethanol, blongs to alcohols-buliding-blocks compound. Safety of 2-(m-Tolyl)ethanol

Example 8-2- [2- (3-methylphenyl) ethoxy]-2′, 3′, 5-TRI-O-(TERT- butyldimethylsilyl)-adenosine [54] To a dry 250-mL, 3-neck roundbottom flask was added 2-chloro- 2′, 3′, 5-TRI-O-(TERT-BUTYLDIMETHYLSILYL) adenosine (5 g, 7.8 mmol, Example 1) and 2- (3-methylphenyl) ethanol (15 mL). The mixture was flushed with nitrogen for 5-10 minutes, then heated to 50 ¡ãC. To this mixture was added sodium hydride (1.56 g, 39 mmol, as a 60percent dispersion in mineral oil) at such a rate as to avoid excessive gas evolution. The reaction was maintained at 50 ¡ãC until the predominant component was the product by HPLC (partially deprotected products were also seen). The reaction was then cooled to room temperature, carefully quenched with water (40 mL), and extracted with ethyl acetate (3 x 100 mL). The combined organic extracts were washed with brine (120 mL), dried (MGS04), filtered, and concentrated under reduced pressure to afford a brown oil. This material was purified by passing through a plug of silica gel, eluting with CH2CL2, 5percent methanol in CHSCIS, and 10percent methanol in CH2CL2. Those fractions containing products were combined and evaporated to dryness, to afford a mixture of starting material and monosilyl-protected and disilyl-protected alkylated products in a ratio of 2: 5: 12.This mixture was used without further purification in the next step

The synthetic route of 1875-89-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KING PHARMACEUTICALS RESEARCH & DEVELOPMENT, INC.; WO2005/33121; (2005); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts