The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1875-89-4, name is 2-(m-Tolyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C9H12O
3-methyl phenethyl alcohol (5 g, 36.7 MMOL) was diluted in 30 mL of chloroform and ammonium nitrate (3.12 g, 38.9 MMOL) was added. The reaction mixture was cooled to 0 °C and trifluor acetic acid anhydride (16.02 mL, 113 MMOL) was added dropwise. The reaction stirred at 0 °C for 3 hours before water was added to slowly quench the reaction. The chloroform layer was washed with water then collected and dried over NA2SO4 then concentrated. The desired isomer crystallized out of the crude solution in ethyl acetate and was then triturated with acetonitrile to afford 5.25 g of the desired isomer as a brown solid. Yield 87percent; MS (APCI) : 199 [M-H]-.
With the rapid development of chemical substances, we look forward to future research findings about 1875-89-4.
Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/41793; (2004); A1;,
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Alcohols – Chemistry LibreTexts