Category: 504-63-2

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.504-63-2, name is 1,3-Propanediol, molecular formula is C3H8O2, molecular weight is 76.0944, as common compound, the synthetic route is as follows.Application In Synthesis of 1,3-Propanediol

General procedure: To a solution of substrate (1 mmol) and acetic anhydride (1.5 mmol) was added supported iron catalyst (Fe/SBA-15) (0.005 mmol, 0.085 g) and the mixture was stirred at 40 C. After completion of the reaction (TLC), the reaction mixture was filtered and the catalyst rinsed with ethyl acetate and heated at 70 C prior to its reuse in the next reaction. The organic layer was washed with saturated NaHCO3 and water, and dried over anhydrous sodium sulfate. The product was obtained after removal of the solvent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,504-63-2, 1,3-Propanediol, and friends who are interested can also refer to it.

Reference:
Article; Rajabi, Fatemeh; Luque, Rafael; Catalysis Communications; vol. 45; (2014); p. 129 – 132;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 504-63-2 ,Some common heterocyclic compound, 504-63-2, molecular formula is C3H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add hexadecane bromide (1.52 g, 5 mmol) to the reaction flask.And 1,3-propanediol (1.14 g, 15 mmol),Add 5 ml of dimethyl sulfoxide and 5 ml of tetrahydrofuran to dissolve.Add sodium hydroxide (800mg, 20mmol)The reaction was carried out for 24 hours at room temperature.Dilute with 10 ml of water,Adjust the pH to neutral with 2M dilute hydrochloric acid,Extracted with ethyl acetate 3 times,Combine the organic phase,Washed with saturated brine and concentrated.Purified by silica gel column chromatography to give compound 1.0g, Yield: 66.7%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 504-63-2, 1,3-Propanediol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Zhao Jiuyang; (46 pag.)CN109485676; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 504-63-2, 1,3-Propanediol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 504-63-2, blongs to alcohols-buliding-blocks compound. Recommanded Product: 504-63-2

Propane-1,3-diol (5.0 g, 65.78 mmol) was taken in 50 mL of dry THF. Next, NaH (60% dispersion in mineral oil, 2.49 g, 65.78 mmol) was added in portions at 0 C. The reaction mixture was stirred at 0 C for 30 min. Tetrabutylammonium iodide (TBAI) (1.6 g, 0.66 mmol) was added to it followed by the addition of 4-methoxybenzylbromide (13.2 g, 65.78 mmol) in THF (50 mL). The reaction mixture was stirred for a further 2 h at room temperature. Ice water (15 mL) was added carefully to the reaction mixture to quench any excess of NaH. The reaction mixture was extracted with EtOAc (50 mL). The organic layer was washed with water (15 mL) and brine (20 mL). Evaporation and purification by means of silica gel chromatography (EtOAc/hexane = 20:80) afforded compound 8 (11.6 g, 90%) as a colorless liquid. IR: nu 3393, 1613, 1513, 1462, 1248 cm-1; 1H NMR (200 MHz, CDCl3): 7.22 (2H, d, J = 8.0 Hz), 6.83 (2H, d, J = 8.0 Hz), 4.41 (2H, s), 3.79 (3H, s), 3.70 (2H, d, J = 7.0 Hz), 3.56 (2H, d, J = 7.0 Hz), 2.52 (1H, br s), 1.86-1.74 (2H, m); 13C NMR (50 MHz): delta; ESIMS: m/z 197 [M+H]+, Anal. Calcd for C11H16O3: C, 67.35; H, 8.16. Found: C, 67.46; H, 8.11.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,504-63-2, its application will become more common.

Reference:
Article; Das, Biswanath; Nagendra, Siddavatam; Reddy, Cheruku Ravindra; Tetrahedron Asymmetry; vol. 22; 11; (2011); p. 1249 – 1254;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 504-63-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 504-63-2, name is 1,3-Propanediol, molecular formula is C3H8O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(1) Put 440kg of 1,3-propanediol, 600kg of hydrochloric acid, and 3kg of benzenesulfonic acid into a 2000L glass-lined kettle with a stirring and reflux condensing device, heat up to 90 C with stirring, and keep the reaction warm;(2) After holding for 3 hours, lower the temperature of the kettle to 50 C, then put 460kg of hydrochloric acid into the kettle, continue to warm to 90 C and keep the reaction for 10 hours. The temperature of the kettle is sampled for GC analysis. When the content reaches 80%, the feed liquid is poured into the distillation kettle, and 150 kg of toluene is poured into the distillation kettle to carry out the reaction of heating and refluxing with water;(3) After the reaction with water is completed, the temperature of the kettle is reduced to room temperature, and sodium bicarbonate is added to neutralize the oil phase in the kettle to neutrality, and the salt formed by the neutralization and excess sodium bicarbonate are filtered;(4) The filtered oil phase is pumped into the rectification kettle, and the solvent toluene is concentrated under normal pressure. After the toluene is collected, the product is rectified by high vacuum. The rectified fraction is put into the reaction kettle to continue the reaction.The content detected by GC gas chromatography was 99.3%, and the product yield was 96%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 504-63-2, 1,3-Propanediol.

Reference:
Patent; Zouping Mingxing Chemical Co., Ltd.; Chen Qiang; Zhang Peng; Zhang Junling; Cao Xinming; Sun Fantong; Wang Tao; Du Xiaoyang; (6 pag.)CN110668918; (2020); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 504-63-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.504-63-2, name is 1,3-Propanediol, molecular formula is C3H8O2, molecular weight is 76.0944, as common compound, the synthetic route is as follows.

To a dried 250 mL RBF under an atmosphere of argon at room temperature was added 1 00 mL of distilled THF and 2.1 g of sodium hydride (60% dispersion in mineral oil; Aldrich). The mixture was stirred vigorously and 1 ,3-propanediol (4.0 g, 50 mmol; Aldrich) was added over 1 0 minutes via syringe. The reaction was allowed to stir for 45 minutes before tert-butyldimethylsilyl chloride (7.9 g, 52.7 mmol; Aldrich) was added portion wise over 5 minutes. The reaction was then allowed to stir for a further 45 minutes at room temperature before being quenched slowly with 20 mL of 10% aqueous sodium carbonate solution. This mixture was then transferred to a separatory funnel. After being vigorously shaken, the biphasic mixture was separated and the aqueous phase was further extracted with two 50 mL portions of ether. The combined organic phases are then dried with sodium sulfate and filtered through a plug of 1 inch of Celite and 1 inch of flash silica (silica gel 60, EMD) via a 100 mL sinter funnel under vacuum into a 500 mL RBF, with the sodium sulfate residue washed with a further 50 mL of ether. The collected solution was then reduced under vacuum on a Buchi rotary evaporator to give compound L, as a light yellow oil in 99% yield and >95% purity

Statistics shows that 504-63-2 is playing an increasingly important role. we look forward to future research findings about 1,3-Propanediol.

Reference:
Patent; THE FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION; PREVACUS, INC.; CRAN, John, W.; HAN, Yinglin; ZHANG, Faliang; WO2014/145302; (2014); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 504-63-2, name is 1,3-Propanediol, molecular formula is C3H8O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 504-63-2

General procedure: To a solution of 1,3-propanediol (19) (6.51 mL, 90 mmol) in dry DMF (40 mL) was added NaH (60% oil dispersion; 1.20 g, 30 mmol) in installments at 0 C and the mixture was stirred at room temperature for 10 min. Dodecyl bromide (4.80 mL, 20 mmol) and KI (3.32 g, 20 mmol) were added and the mixture was heated at 95 C for 4 h. After cooling, the mixture was poured into ice-water and extracted with AcOEt. The extracts were washed with brine, dried over Na2SO4 and evaporated. The resulting residue was purified by flash CC (silica gel; AcOEt/hexane, 1:2) to provide dodecyl ether 20a (3.38 g, 69%). Tetradecyl ether 20b (79%) and hexadecyl ether 20c (77%) were similarly prepared from 1,3-propanediol (19).

With the rapid development of chemical substances, we look forward to future research findings about 504-63-2.

Reference:
Article; Yamano, Yumiko; Tsuboi, Kazuhito; Hozaki, Yuki; Takahashi, Kiyohiro; Jin, Xing-Hua; Ueda, Natsuo; Wada, Akimori; Bioorganic and Medicinal Chemistry; vol. 20; 11; (2012); p. 3658 – 3665;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 504-63-2 ,Some common heterocyclic compound, 504-63-2, molecular formula is C3H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure A: Synthesis of acetal protected aldehydes 1,3-Propanediol (1.5 eq.) and p-TSA (0.1 eq.) were added to a solution of aldehyde (5.0 mmol, 1.0 eq.) in toluene. The reaction was heated to reflux and left to stir for 7 hours. After cooling to room temperature, the reaction was washed with three portions of H2O, dried over MgSO4 and the solvent removed under reduced pressure to afford the crude acetal protected product. General procedure A was followed using 2-bromobenzaldehyde (925 mg, 5.00 mmol), followed by recrystallization from petrol:ether, to provide the title compound as white needles in 88% yield (1.07g, 4.40 mmol). m.p. 83-84 C; 1H NMR (300 MHz, CDCl3) deltaH: 7.69 (1H, dd, J = 7.8, 1.7 Hz, ArH), 7.52 (1H, dd, J = 8.0, 1.3 Hz, ArH), 7.33 (1H, td, J = 7.6, 1.2 Hz, ArH), 7.19 (1H, td, J = 7.7, 1.7 Hz, ArH), 5.76 (1H, s, CH), 4.29 (1H, dd, J = 5.1, 1.3 Hz, OCHAHB), 4.25 (1H, dd, J = 5.1, 1.3 Hz, OCHAHB), 4.03 (2H, td, J = 12.2, 2.4 Hz, OCH2), 2.32-2.16 (1H, m, CH2CHAHBCH2), 1.48-1.41 (1H,m, CH2CHAHBCH2); 13C{1H} NMR (75.5 MHz CDCl3) deltaC: 137.5, 132.6, 130.3, 128.0, 127.5, 122.3, 100.9, 67.6, 25.7; I.R (thinfilm) nu max (cm-1): 1594 (ArC=C), 1570 (ArC=C); HRMS (ESI): m/z calculated for C10H11BrO2: requires: 264.9840 for [M+Na]+; found: 264.9839.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,504-63-2, its application will become more common.

Reference:
Article; Peacock, Lucy R.; Chapman, Robert S. L.; Sedgwick, Adam C.; Bull, Steven D.; Mahon, Mary F.; Amans, Dominique; Organic Letters; vol. 17; 4; (2015); p. 994 – 997;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 504-63-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 504-63-2, name is 1,3-Propanediol. A new synthetic method of this compound is introduced below.

Synthesis of Intermediate L Compound L was prepared according to the procedure of McDougal, P. G.; Rico, J. G.; Oh, Y.-L; Condon, B. J. Org. Chem., 1986, 51, 3388-3390. To a dried 250 mL RBF under an atmosphere of argon at room temperature was added 100 mL of distilled THF and 2.1 g of sodium hydride (60% dispersion in mineral oil; Aldrich). The mixture was stirred vigorously and 1,3-propanediol (4.0 g, 50 mmol; Aldrich) was added over 10 minutes via syringe. The reaction was allowed to stir for 45 minutes before tert-butyldimethylsilyl chloride (7.9 g, 52.7 mmol; Aldrich) was added portion wise over 5 minutes. The reaction was then allowed to stir for a further 45 minutes at room temperature before being quenched slowly with 20 mL of 10% aqueous sodium carbonate solution. This mixture was then transferred to a separatory funnel. After being vigorously shaken, the biphasic mixture was separated and the aqueous phase was further extracted with two 50 mL portions of ether. The combined organic phases are then dried with sodium sulfate and filtered through a plug of 1 inch of Celite and 1 inch of flash silica (silica gel 60, EMD) via a 100 mL sinter funnel under vacuum into a 500 mL RBF, with the sodium sulfate residue washed with a further 50 mL of ether. The collected solution was then reduced under vacuum on a Buchi rotary evaporator to give compound L, as a light yellow oil in 99% yield and >95% purity. The 1H NMR spectrum in CDCI3 agreed with the previously reported data. (See, McDougal, P. G.; Rico, J. G.; Oh, Y.-L; Condon, B. J. Org. Chem., 1986, 51, 3388-3390.)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,504-63-2, 1,3-Propanediol, and friends who are interested can also refer to it.

Reference:
Patent; PREVACUS, INC.; THE FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.; LEVY, Daniel, E.; CRAN, John, W.; (93 pag.)WO2016/44558; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 504-63-2, name is 1,3-Propanediol, molecular formula is C3H8O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 504-63-2

General procedure A: Synthesis of acetal protected aldehydes 1,3-Propanediol (1.5 eq.) and p-TSA (0.1 eq.) were added to a solution of aldehyde (5.0 mmol, 1.0 eq.) in toluene. The reaction was heated to reflux and left to stir for 7 hours. After cooling to room temperature, the reaction was washed with three portions of H2O, dried over MgSO4 and the solvent removed under reduced pressure to afford the crude acetal protected product. General procedure A was followed using 2-bromo-5-methoxybenzaldehyde (1.08 g, 5.00 mmol), to provide the title compound as an orange oil in 96% yield (1.31 g, 4.80 mmol), which was used without further purification. 1H NMR (300 MHz, CDCl3) deltaH: 7.40 (1H, d, J = 8.9 Hz, ArH), 7.24 (1H, d, J = 3.1 Hz, ArH), 6.76 (1H, dd, J = 8.8, 3.3 Hz, ArH), 5.71 (1H, s, CH), 4.28 (1H, dd, J = 5.1, 1.3 Hz, OCHAHB), 4.24 (1H, dd, J = 5.1, 1.3 Hz, OCHAHB), 4.02 (2H, td, J = 12.2, 2.5 Hz, OCH2), 3.80 (3H, s, OCH3), 2.32-2.16 (1H, m, CH2CHAHBCH2), 1.48-1.41 (1H, m, CH2CHAHBCH2); 13C{1H} NMR (75.5 MHz CDCl3) deltaC: 159.2, 138.3, 133.3, 117.2, 112.8, 112.7, 100.9, 67.7, 55.6, 25.8; I.R (thinfilm) nu max (cm-1): 1596 (ArC=C), 1575 (ArC=C); HRMS (ESI): m/z calculated for C11H13BrO3: requires: 273.0126 for [M+H]+; found: 273.0129.

With the rapid development of chemical substances, we look forward to future research findings about 504-63-2.

Reference:
Article; Peacock, Lucy R.; Chapman, Robert S. L.; Sedgwick, Adam C.; Bull, Steven D.; Mahon, Mary F.; Amans, Dominique; Organic Letters; vol. 17; 4; (2015); p. 994 – 997;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 504-63-2 ,Some common heterocyclic compound, 504-63-2, molecular formula is C3H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 3 2-(2-Bromophenyl)-[1,3]dioxane (5a). ortho-Bromobenzaldehyde (4a) (8 g, 43.24 mmol) was stirred with 1,3 propanediol (4.7 ml, 64.86 mmol) and p-toluenesulfonic acid monohydrate (164 mg, 0.86 mmol) in benzene (150 ml) in a flask equipped with a Dean-Stark trap and a condenser. The mixture was heated at reflux for 12 hrs, cooled, and extracted with 2 M NaOH (100 ml), and brine (100 ml*3). The solution was dried over MgSO4, and the solvent evaporated to the title compound in quantitative yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 504-63-2, 1,3-Propanediol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PURDUE RESEARCH FOUNDATION; US2009/30025; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts