Synthetic Route of 50438-75-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50438-75-0, name is 2-(4-(Dimethylamino)phenyl)ethanol, molecular formula is C10H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2- [4- (N,] N-dimethylaminophenyl] ethanol (2.05 g, 17.4 mmol), phthalimide (2.19 g, 14.9 mmol) and [PPH3] (3.93 g, 14.9 mmol) (Aldrich) are mixed in 100 mL of THF maintained at [0C.] The mixture is then treated with DIAD (2.68 mL) (Aldrich) which was added dropwise. After stirring overnight, the solvent is removed under reduced pressure to give a pale yellow solid. The solid is triturated with EtOAc three times. The combined EtOAc layers are treated with gaseous HC1 to precipitate the product, and the desired product is isolated through filtration.
According to the analysis of related databases, 50438-75-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ELIAN PHARMACEUTICALS INC; WO2004/33436; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts