Category: 27129-87-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27129-87-9, name is (3,5-Dimethylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of (3,5-Dimethylphenyl)methanol

General procedure: A dried round bottomed flask equipped with a magnetic stir bar was charged with 15 mg Polymer anchored-Pd(II) C catalyst (PS-8-AQ-Pd), 2-phenyl pyridine (0.5 mmol), benzyl alcohol (1.0 mmol)and TBHP (2.0 mmol) were added to a reaction vessel. The mixture was stirred at 110 C for 8 h, then cooled to room temperature and catalyst was filtered, the filtrate was extracted with ethyl acetate(3 10 mL). The combined organic layers were extracted with water, and dried over anhydrous Na2SO4. The organic layers were evaporated under reduced pressure and the resulting crude product was purified by column chromatography by using ethylacetate/hexane (1:4) as eluent to give the corresponding ortho acylation products. The products were characterized by 1H NMR,13C NMR and HRMS.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27129-87-9, (3,5-Dimethylphenyl)methanol.

Reference:
Article; Perumgani, C. Pullaiah; Parvathaneni, Sai Prathima; Kodicherla, Balaswamy; Keesara, Srinivas; Mandapati, Mohan Rao; Inorganica Chimica Acta; vol. 455; (2017); p. 105 – 111;,
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Electric Literature of 27129-87-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.27129-87-9, name is (3,5-Dimethylphenyl)methanol, molecular formula is C9H12O, molecular weight is 136.191, as common compound, the synthetic route is as follows.

General procedure: A glass vial fitted with magnetic stirrer and a magnetic bar containing a reaction mixture of alcohol (0.1 mmol), NH4SCN (3 eq.), catalyst (5 mol%) and 2 ml of solvent. The vial was closed with rubber septum and O2 was bubbling for 15 minutes using needles. The reaction mixture was irradiated under a 23W CFL lamp for a certain time period. Reaction progress was monitored by TLC. After, completion of the reaction, a yellow solid was formed. The reaction mixture of three vials with the same content were combined and filter it through whatman filter paper. The mixture was evaporated under reduced pressure and purified by column chromatography using hexane/ethyl acetate as eluent. Further, the reaction mixture was run on a GC-MS instrument for characterisation. Yield, conversion and selectivity were calculated using following equations.

Statistics shows that 27129-87-9 is playing an increasingly important role. we look forward to future research findings about (3,5-Dimethylphenyl)methanol.

Reference:
Article; Sheriff Shah, Sk; Pradeep Singh; Tetrahedron Letters; vol. 59; 3; (2018); p. 247 – 251;,
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Adding a certain compound to certain chemical reactions, such as: 27129-87-9, (3,5-Dimethylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H12O, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H12O

Step 1 1-(2-Aminoethyl)-3-(3,5-dimethylbenzyl)-2-imidazolidinylidenepropanedinitrile (Compound (IXa)): 1-(2-Aminoethyl)-2-imidazolidinylidenepropanedinitrile (9.7 g) obtained by a known process (JP92-279581), 5.0 g of 3,5-dimethylbenzyl alcohol, 12 g of triphenylphosphine, and 10 g of di-tert-butyl azodicarboxylate were allowed to react in 500 ml of tetrahydrofuran as described in Example 23 to give 3.6 g (34%) of Compound (IXa) as a pale yellow oily substance. 1H NMR (270 MHz, CDCl3) delta: 6.89 (1H, s), 6.81 (2H, s), 4.62 (2H, s), 3.62-3.55 (4H, m), 3.42-3.34 (2H, m), 2.98 (2H, t), 2.25 (6H, s). The signal which corresponds to primary amine was not observed.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,27129-87-9, (3,5-Dimethylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; Kyowa Hakko Kogyo Co., Ltd.; US6469002; (2002); B1;,
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Application of 27129-87-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27129-87-9, name is (3,5-Dimethylphenyl)methanol. A new synthetic method of this compound is introduced below.

The 0.91 g (0.0067 muM) of 3, 5 – dimethyl benzoic alcohol and 0.4 g of the dispersed GO – Ti 10 ml in tetrahydrofuran, and in the oil bath heated to 70 C, 1 . 89 g (0.0167 muM) of 30 wt % aqueous hydrogen peroxide solution in tetrahydrofuran is slowly added, keeping the temperature reaction 5 h, by HPLC detection, 3, 5 – dimethylphenyl methanol conversion rate is 91.3%, 3, 5 – dimethyl formaldehyde selectivity of 98.2%. After filtering to remove the catalyst concentrated filtrate, separation by silica gel column chromatography to obtain 3, 5 – dimethyl benzaldehyde 0.85 g, yield: 94.5%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27129-87-9, its application will become more common.

Reference:
Patent; Shenyang Pharmaceutical University; Wang Qinghe; Cheng Maosheng; Ma Wenxi; Tong Qiaolin; Wang Shicheng; (8 pag.)CN108395369; (2018); A;,
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Electric Literature of 27129-87-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 27129-87-9 as follows.

Step 2: 3,5-Dimethylbenzyl 4-((tert-butoxycarbonyl)amino)piperidine-1-carboxylate To a stirred solution of (3,5-dimethylphenyl)methanol (1.020 g, 7.49 mmol) in DMF (5 mL) at RT was added CU (1.214 g, 7.49 mmol). The reaction mixture was heated at 50 C. for 20 hrs. Tert-butyl piperidin-4-ylcarbamate (1.5 g, 7.49 mmol) was added and the reaction mixture stirred at 50 C. for 4 hrs. The mixture was diluted with EtOAc and washed with a saturated solution of sodium bicarbonate, brine, dried over MgSO4, filtered and concentrated under reduced pressure. Purification was carried out by chromatography on silica using 0-100% EtOAc in hexanes as eluent to afford the title product. LC-M: Rt 1.47 mins; MS m/z 263.3, 264.2; [M-Boc]+; Method 2minLowpHv03

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27129-87-9, its application will become more common.

Reference:
Patent; Novartis AG; Legrand, Darren Mark; Furminger, Vikki; Thomson, Christopher; Hughes, Owen Rhys; Stanley, Emily; US2014/171403; (2014); A1;,
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Reference of 27129-87-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 27129-87-9 as follows.

1-(chloromethyl)-3,5-dimethylbenzene was prepared from (3,5-dimethylphenyl)methanol and thionyl chloride: thionyl chloride (300 muL, 4.13 mmol, 11.8 M) and (3,5-dimethylphenyl)methanol (50 muL, 0.39 mmol, 1.1 M) were added to a NMR tube, capped. Teflon wrapping around the cap of nmr tube was used to prevent reaction mixture from leaking out. The NMR tube was heated at reflux under air (100 C) for 10 min. After cooling to 23 C, the nmr cap was replaced by a septum and volatiles were removed under vacuum via a needle through the septum. A solution (300 muL) of (1,4-bis(trifluoromethyl)benzene in C6D6 was added to the product mixture for 1H{13C} NMR analysis. All (3,5-dimethylphenyl)methanol was converted at the end of reaction. 1H{13C} NMR chemical shifts of 1-(chloromethyl)-3,5-dimethylbenzene: 6.75 ppm (2H, arene CH, s), 6.68 ppm (1H, arene CH, s), 4.15 ppm (2H, CH2Cl, s), 2.04 ppm (6H, benzylic CH3, s). 13C{1H} NMR chemical shifts of 1-(chloromethyl)-3,5-dimethylbenzene: 138.3 (s), 138.8 ppm (s),130.7 ppm (s), 127.4 ppm (s), 46.97 ppm, 21.65 ppm (s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27129-87-9, its application will become more common.

Reference:
Article; Zhou, Meng; Goldman, Alan S.; Molecules; vol. 20; 6; (2015); p. 10122 – 10130;,
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Adding a certain compound to certain chemical reactions, such as: 27129-87-9, (3,5-Dimethylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H12O, blongs to alcohols-buliding-blocks compound. Computed Properties of C9H12O

Example 174 Synthesis of methyl 3-[4-(3,5-dimethylphenylmethyloxy)-3-(1H-indol-5-yl)-phenyl]Propionate (Compound No. 174) (Preparation Method 5, Step e-2) A solution of Intermediate 55 (80 mg) and TMAD (69 mg, TCI) in anhydrous THF (1.5 ml) was added with 3,5-dimethylbenzyl alcohol (59 mul, Ald), added dropwise with nBu3P (110 mul, KANTO) under ice cooling, gradually warmed to room temperature and stirred for 13 hours.The reaction mixture was filtered, and the solvent of the filtrate was evaporated under reduced pressure.The residue was purified by column chromatography (Quad, hexane:ethyl acetate=7:1) to obtain the title compound (Compound No. 174, 123 mg).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,27129-87-9, (3,5-Dimethylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Shoda, Motoshi; Kuriyama, Hiroshi; US2004/44258; (2004); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27129-87-9, name is (3,5-Dimethylphenyl)methanol. A new synthetic method of this compound is introduced below., 27129-87-9

Compound Ba (2.5 g, 95%) was obtained as colorless crystals using Compound A (1.8 g) obtained in Reference Example 1, 3,5-dimethylbenzyl alcohol (1.7 mL), triphenylphosphine (3.0 g), diethyl azodicarboxylate (1.8 mL) and tetrahydrofuran (7.5 mL) as described in Example 14. [0458] 1H NMR (270 MHz, CDCl3) delta6.96 (1H, brs), 6.86 (2H, brs), 4.68 (2H, s), 4.17 (2H, q), 3.89 (2H, t), 3.65 (2H, dd), 3.42 (2H, dd), 2.79 (2H, t), 2.31 (6H, s), 1.28 (3H, t).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,27129-87-9, (3,5-Dimethylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; Kyowa Hakko Kogyo Co., Ltd.; US2003/225288; (2003); A1;,
Alcohol – Wikipedia,
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