Category: 1454-84-8

Application of 1454-84-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1454-84-8, name is 1-Nonadecanol, molecular formula is C19H40O, molecular weight is 284.5203, as common compound, the synthetic route is as follows.

General procedure: Methyl 3-hydroxy-2-naphthoate (1mmol) in DMF was added to allyl bromide (1mmol) in the presence of NaH (55%), and stirred at 60 C for 1 day. The solvent was evaporated in vacuo, and the product was extracted with ether three times. The organic phase was dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. After the alkaline hydrolysis, thionyl chloride was added to prepare the 2-allyloxy-3-naphthoeic acid chloride. Then, either alkyl alcohol or alkyl amine (1mmol; n = 18, 19) with triethylamine(1mmol) was reacted in THF to produce the S1-OCn or S1-NCn, respectively. The products were purified by silica gel column chromatography with CHCl3 as an eluent. The S1-OCn(S1-NCn) was heated at 160 C for 60 min under vacuum without any solvent, and following column chromatography resulted in the production of S2-OCn (S2-NCn).

Statistics shows that 1454-84-8 is playing an increasingly important role. we look forward to future research findings about 1-Nonadecanol.

Reference:
Article; Kikkawa, Yoshihiro; Ishitsuka, Manami; Omori, Kazuhiro; Kashiwada, Ayumi; Tsuzuki, Seiji; Hiratani, Kazuhisa; Bulletin of the Chemical Society of Japan; vol. 88; 6; (2015); p. 834 – 842;,
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Electric Literature of 1454-84-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1454-84-8, name is 1-Nonadecanol. A new synthetic method of this compound is introduced below.

General procedure: A mixture of succinic anhydride (1.0 eq) and dry alcohol (1 eq) in toluene (4 mL) was heated at reflux 2.5 h. The toluene was removed under reduced pressure and the residue was taken up in water, and the solution was extracted with dichloromethane, dried (MgSO4), and evaporated to afford monoalkylsuccinic acid. A solution of monoalkyl succinic acid (1.2 eq) and thionyl chloride (1.4 eq) in benzene (5 mL) was refluxed for 3 h. Subsequently, the majority of the SOCl2 and benzene were removed by distillation. The mixture was cooled down to room temperature and dried under a vacuum to give a crude chlorocarbony-alkyl ester. A solution of chlorocarbonyl-alkyl ester in dichloromethane (5 mL) was added to a round flask containing 14 (1 eq) by cannula, and subsequently added pyridine (1.4 eq). The resulting solution was stirred at room temperature overnight, and quenched by adding water. The solution was extracted with ethyl acetate, dried (MgSO4), and evaporated to give a residue which was purified by column chromatography (Al2O3), eluting by ethyl acetate /hexane (1:15) to provide 25-43.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1454-84-8, its application will become more common.

Reference:
Article; Yin, Kai-Hao; Hsieh, Yi-Han; Sulake, Rohidas S.; Wang, Su-Pei; Chao, Jui-I.; Chen, Chinpiao; Bioorganic and Medicinal Chemistry Letters; vol. 24; 22; (2014); p. 5247 – 5250;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts