With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1219019-22-3, name is cis-3-Aminocyclobutanol hydrochloride, molecular formula is C4H10ClNO, molecular weight is 123.58, as common compound, the synthetic route is as follows.Product Details of 1219019-22-3
To a solution of cis-3-aminocyclobutanol hydrochloride (900 mg, 7.3 mmol, 1.0 eq) in ethanol (5 mL) and Et3N (5 mL) at 0 C. was added Boc2O (800 mg, 3.7 mmol, 0.5 eq) and the mixture was allowed to warm to RT and stirred for 3 h. The mixture was concentrated under reduced pressure, diluted with water (50 mL) and extracted with EtOAc (40 mL*3). The combined organic layers were washed with brine (50 mL), dried over Na2SO4 and concentrated under reduced pressure to afford the title compound (1.2 g, 88%) as a yellow solid, which was used for the next step without further purification. LCMS: [M+H]+ 188.2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1219019-22-3, cis-3-Aminocyclobutanol hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; Ribon Therapeutics Inc.; Schenkel, Laurie B.; Vasbinder, Melissa Marie; Kuntz, Kevin Wayne; Swinger, Kerren Kalai; (179 pag.)US2019/194174; (2019); A1;,
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