Category: 20017-67-8

Synthetic Route of 20017-67-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 20017-67-8, name is 3,3-Diphenyl-1-propanol. A new synthetic method of this compound is introduced below.

A solution (5 ML) of 1-(2-hydroxy-5-nitrophenyl)propan-1-one (500 mg, 2.56 mmol), 3,3-diphenylpropanol (765 mg, 3.84 mmol), 1,1-(azodicarbonyl)dipiperidine (969 mg, 3.84 mmol) and triphenylphosphine (1.01 g, 3.84 mmol) in toluene was stirred for 4 hours at 80C, and to the reaction solution were added 3,3-diphenylpropanol (765 mg, 3.84 mmol), 1,1-(azodicarbonyl)dipiperidine (969 mg, 3.84 mmol), triphenylphosphine (1.01 g, 3.84 mmol) and toluene (5 ML).. The mixture was stirred for 4 hours at 80C. To the reaction solution were further added 3,3-diphenylpropanol (765 mg, 3.84 mmol), 1,1-(azodicarbonyl)dipiperidine (967 mg, 3.84 mmol), triphenylphosphine (1.01 g, 3.84 mmol) and toluene (5 ML), and the mixture was stirred for 12 hours at 80C. The reaction solution was poured into water, and was extracted with ethyl acetate.. The extracted solution was washed with water, was dried with anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure.. The residue was purified by silicagel column chromatography (hexane:ethyl acetate = 20:1), to obtain the titled compound as oil. 600 mg (60.2%) 1H-NMR (CDCl3) delta; 1.23 (3H, t, J = 7.2 Hz), 2.58 – 2.69 (2H, m), 3.04 (2H, q, J = 7.2 Hz), 4.07 to 4.25 (3H, m), 6.87 (1 H, d, J = 9.0 Hz), 7.15 to 7.36 (10H, m), 8.24 (1H, dd, J = 9.0, 2.8 Hz), 8.55 (1H, d, J = 2.8Hz)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,20017-67-8, 3,3-Diphenyl-1-propanol, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1437344; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20017-67-8, name is 3,3-Diphenyl-1-propanol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

Dicyclohexylcarbodiimide (12.6 g, 62.4 mmol) is added portion wise with stirring to a solution of difluroacetic acid (4.0 g, 4.0 mL, 62.4 mmol), 3, [3-DIPHENYL-1-] propanol (14.4 g, 13.8 mL, 68.4 mol) and 4-dimethylaminopyridine (732 mg, 6.2 mmol) in ethyl ether (180 [ML)] at [0-5 C.] The reaction mixture is allowed to warm up to r. t. , and stirred at r. t. overnight. Precipitated urea by-product is filtered off and washed with excesses of ethyl ether. Combined filtrates are removed under vacuum, and the title compound is purified by silica gel flash chromatography (eluent: 5% ethyl ether in hexanes). White crystalline solid (17.3 g, 96%). [HPLC] Rt = 7.2. MS (m/z) : 291 [[M+H] +.]

The synthetic route of 20017-67-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/33449; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 20017-67-8, 3,3-Diphenyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 20017-67-8, blongs to alcohols-buliding-blocks compound. Product Details of 20017-67-8

Example 13 3-[4-(3,3-Diphenyl-propoxy)-phenyl]-2-ethoxy-propionic acid ethyl ester Reaction of 3,3-diphenyl-propan-1-ol (110 mg, 0.5 mmol), triphenylphosphine (145 mg, 0.55 mmol), 2-ethoxy-3-(4-hydroxy-phenyl)-propionic acid ethyl ester (140 mg, 0.6 mmol) and diethylazodicarboxylate (0.09 mL, 0.55 mmol) in an identical manner to Example 1 gave the title compound (120 mg). 1H NMR (CDCl3, 300 MHz); delta 1.10-1.29 (6H, 2*CH3), 2.44-2.55 (2H, CH2), 2.90-2.95 (2H, CH2), 3.28-3.39 and 3.51-3.62 (2H, OCH2), 3.80-3.89 (2H, CH2), 3.90-3.95 (1H, CHCO2), 4.10-4.28 (3H, arylCH and OCH2), 6.70-6.77 (2H, aryl), 7.05-7.35 (remaining H, aryl). MS calcd for C28H32O4 432.6, Found 432.3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20017-67-8, its application will become more common.

Reference:
Patent; Novo Nordisk, A/S; US6972294; (2005); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 20017-67-8, 3,3-Diphenyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

To a stirred solution of difluoroacetic acid (5.00 g, 52.1 mmol) and 3,3- diphenyl-1-propanol (11.4 ml, 57.3 mmol, 1.10 eq) in diethyl ether (100 ml) is added [4-DIMETHYLAMINOPYRIDINE] (0.64 g, 5.21 mmol, 0. [01 EQ)] followed by [DIISOPROPYLCARBODIIMIDE] (6.56 g, 52.1 mmol, 1.0 [EQ).] The mixture is stirred at room temperature overnight. The precipitate is removed by vacuum filtration and washed with ether and the filtrate concentrated in vacuo. The residue is filtered through a plug of silica gel using 5% ether/hexanes eluent and the filtrate collected and concentrated. The resulting compound (14.40 g, 46.64 mmol) in xylenes (150 [ML)] is added Lawesson’s Reagent (24.1 g, 59.61 [MMOL).] The reaction mixture is heated at reflux overnight and then cooled to room temperature. A precipitate formed which is removed by vacuum filtration and washed with ethyl acetate. The filtrate is passed through a plug of silica gel and eluted with 5% ether/hexanes and concentrated to give the title compound [7. 1H NMR] (400 [MHZ),] CDC13) 8 2.47, 4.07, 4.24, 5.82, 7.23.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,20017-67-8, 3,3-Diphenyl-1-propanol, and friends who are interested can also refer to it.

Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/2967; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20017-67-8, name is 3,3-Diphenyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C15H16O

To a stirred solution of difluoroacetic acid (5.00 g, 52.1 mmol) and 3,3- diphenyl-l-propanol (11.4 ml, 57.3 mmol, 1.10 eq) in diethyl ether (100 ml) is added 4-dimethylaminopyridine (0.64 g, 5.21 mmol, 0. 01 eq) followed by diisopropylcarbodiimide (6.56 g, 52.1 mmol, 1.0 eq). The mixture is stirred at room temperature overnight. The precipitate is removed by vacuum filtration and washed with ether and the filtrate concentrated in vacuo. The residue is filtered through a plug of silica gel using 5% ether/hexanes eluent and the filtrate collected and concentrated. The resulting compound (14.40 g, 46.64 mmol) in xylenes (150 ml) is added Lawesson’s Reagent (24.1 g, 59.61 mmol). The reaction mixture is heated at reflux overnight and then cooled to room temperature. A precipitate formed which is removed by vacuum filtration and washed with ethyl acetate. The filtrate is passed through a plug of silica gel and eluted with 5% ether/hexanes and concentrated to give the title compound 3. 1H NMR (400 Mhz), CDCl3) 8 2.47, 4.07, 4. 24,5. 82,7. 23.

With the rapid development of chemical substances, we look forward to future research findings about 20017-67-8.

Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/2479; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 20017-67-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20017-67-8, name is 3,3-Diphenyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1. Preparation of difluoroacetic acid, O-(3,3-diphenyl-propyl) ester. [0299] Dicyclohexylcarbodiimide (12.6 g, 62.4 mmol) is added portionwise with stirring to a solution of difluoroacetic acid (4.0 g, 4.0 mL, 62.4 mmol), 3,3-diphenyl-1-propanol (14.4 g, 13.8 mL, 68.4 mol) and 4-dimethylaminopyridine (732 mg, 6.2 mmol) in ethyl ether (180 mL) at 0-5 C. The reaction mixture is allowed to warm up to r.t., and stirred at r.t. overnight. The precipitated urea by-product is filtered off and washed with excess ethyl ether. The combined filtrates are evaporated under vacuum, and the residue is purified by silica gel flash chromatography (eluent: 5% ethyl ether in hexanes). White crystalline solid (17.3 g, 96%). HPLC Rt=7.2. MS (m/z): 291 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 20017-67-8, 3,3-Diphenyl-1-propanol.

Reference:
Patent; Gordeev, Mikhail F.; Renslo, Adam; Luehr, Gary W.; Lam, Stuart; Westlund, Neil E.; Patel, Dinesh V.; US2003/232812; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 20017-67-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 20017-67-8, name is 3,3-Diphenyl-1-propanol. A new synthetic method of this compound is introduced below.

Methanesulfonyl chloride (2.16 g, 18.8 mmol) was slowly added to an ice-cooled solution of 3,3-diphenylpropan-1 -ol ( 4.0 g, 18.8 mmol) and thethylamine (5.7 g, 56.5 mmol) in dichloromethane (18 ml_). The mixture was then allowed to warm to room temperature and stirred overnight. It was then diluted with water and dichloromethane. The phases were separated and the aqueous phase was re- extracted twice with dichloromethane. The combined organic phases were dried over Na2SO4 and concentrated to dryness, providing the desired compound as a crude that was directly used without further purification.1H NMR (300 MHz, CDCI3) delta: 2.53 (m, 2H), 2.91 (s, 3H), 4.13-4.21 (m, 3H), 7.2- 7.35 (m, 10H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,20017-67-8, its application will become more common.

Reference:
Patent; PALAU PHARMA, S. A.; CARCELLER GONZALEZ, Elena; VIRGILI BERNADO, Marina; WO2010/43633; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 20017-67-8, Adding some certain compound to certain chemical reactions, such as: 20017-67-8, name is 3,3-Diphenyl-1-propanol,molecular formula is C15H16O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20017-67-8.

Step l In a round bottom flask under a nitrogen atmosphere, 3,3-Diphenylpropan-l-ol (5.0Og, 23.6 mmol) and TEA (7.15g, 70.8 mmol) were dissolved in CHCl3 (75 mL, dry). The solution was cooled with an ice-salt bath to -15C. Methane sulphonylchloride (6.72g, 59.0 mmol) was added dropwise over a period of 10 min. The solution was gradually allowed to warm to O0C and stored in the fridge at 4C overnight. The yellow/orange solution was then quenched with ice-water (ca 150 mL) and the layers were separated. The water layer was washed with CH2Cl2 (2 * 75mL), and the combined organic layers were dried (MgSO4), filtered and concentrated in vacuo at 200C. This yielded an oil that solidified upon standing (8.16g). The solid was ground, triturated with petroleum ether (50 mL) and the solid was collected by filtration (7.9Og off-white solid).

According to the analysis of related databases, 20017-67-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KING’S COLLEGE LONDON; WO2008/87421; (2008); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 20017-67-8, name is 3,3-Diphenyl-1-propanol, the common compound, a new synthetic route is introduced below. Recommanded Product: 20017-67-8

EXAMPLE 29 9-(3,3-Diphenylpropoxy)-9H-indeno[1,2-b]pyrazine-2,3(1H, 4H)-dione A suspension of 9-hydroxy-9H-indeno[1,2-b]pyrazine-2,3(1H, 4H)-dione. 1H2 O (1.0 g, 4.26 mmol) in benzene (40 ml), 3,3-diphenyl-1-propanol (10 ml) and p-toluensulfonic acid (40 mg) was refluxed with water separation for 48 hours. The reaction mixture was evaporated in vacuo to dryness, the residue was suspended in ethanol (10 ml) and the precipitate was filtered off and washed with ethanol and dried to give 0.224 g (12.5%) of the title compound. M.p. 224-228 C. 1 H-NMR(DMSO-d6, delta): 2.14-2.32 (m, 2H), 3.0-3.22 (m, 2H), 4.13 (t, 1H), 5.22 (s, 1H), 7.0-7.5 (m, 14H), 12.12 (s, 1H), 12.26 (s, 1H). Analysis: Calculated for C26 H22 N2 O3.1/2H2 O: C, 74.45; H, 5.53; N, 6.68%. Found: C, 74.37; H, 5.58; N, 6.28%.

The synthetic route of 20017-67-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Faarup; Peter; Jakobsen; Palle; Jorgensen; Anker S.; Klitgaard; Henrik; US5468748; (1995); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts