The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20017-67-8, name is 3,3-Diphenyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C15H16O
To a stirred solution of difluoroacetic acid (5.00 g, 52.1 mmol) and 3,3- diphenyl-l-propanol (11.4 ml, 57.3 mmol, 1.10 eq) in diethyl ether (100 ml) is added 4-dimethylaminopyridine (0.64 g, 5.21 mmol, 0. 01 eq) followed by diisopropylcarbodiimide (6.56 g, 52.1 mmol, 1.0 eq). The mixture is stirred at room temperature overnight. The precipitate is removed by vacuum filtration and washed with ether and the filtrate concentrated in vacuo. The residue is filtered through a plug of silica gel using 5% ether/hexanes eluent and the filtrate collected and concentrated. The resulting compound (14.40 g, 46.64 mmol) in xylenes (150 ml) is added Lawesson’s Reagent (24.1 g, 59.61 mmol). The reaction mixture is heated at reflux overnight and then cooled to room temperature. A precipitate formed which is removed by vacuum filtration and washed with ethyl acetate. The filtrate is passed through a plug of silica gel and eluted with 5% ether/hexanes and concentrated to give the title compound 3. 1H NMR (400 Mhz), CDCl3) 8 2.47, 4.07, 4. 24,5. 82,7. 23.
With the rapid development of chemical substances, we look forward to future research findings about 20017-67-8.
Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/2479; (2004); A1;,
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