Category: 25125-21-7

Electric Literature of 25125-21-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.25125-21-7, name is 1-Hydroxymethyl-3-cyclopentene, molecular formula is C6H10O, molecular weight is 98.143, as common compound, the synthetic route is as follows.

1-a (Cyclopent-3-en-1-yl)methyl toluenesulfonate A mixture of (cyclopent-3-en-1-yl)methanol (1.96 g, 20 mmol) and para-toluenesulfonylchloride (3.81 g, 20 mmol) were stirred at room temperature for 2 hrs in pyridine (30 ml). After the concentration of pyridine, the reaction residues were extracted with dichloromethane, washed 1N HCl, dried with MgSO4, concentrated and separated by the column chromatography to give the desirable product (4.20 g). Yield(%): 83.2 1 H NMR(CDCl3): delta2.11(2H,m), 2.42(3H,s), 2.49(3H,m), 3.82(2H,d), 5.67(2H,s), 7.40(2H,d), 7.65(2H,d).

The chemical industry reduces the impact on the environment during synthesis 25125-21-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Samjin Pharmaceutical Co., Ltd; US5922727; (1999); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 25125-21-7, 1-Hydroxymethyl-3-cyclopentene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 25125-21-7, blongs to alcohols-buliding-blocks compound. Recommanded Product: 25125-21-7

To a solution of cyclopent-3-enylmethanol 146-2 (4.0 g, 41 mmol) in dichloromethane (150 mL) at 0C was added 3-chloroperbenzoic acid (10 g, 45 mmol, 77% purity) by portion. The reaction was stirred overnight. Dichloromethane (150 mL) was added. The organics was washed with sodium thiosulfate (12 g in 10 mL water), followed by saturated NaHCCb (40 mL). This was repeated till all the remaining 3-chloroperbenzoic acid was washed away. The organic was dried over MgSC. Evaporation of solvent gave a mixture of cis- and trans- 6- oxabicyclo[3.1.0]hexan-3-ylmethanol 146-3 (2.6 g, 57 %) as a yellow oil. GC-MS: m/z 114 (5) (M+), 95 (15), 88 (100), 81 (15).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,25125-21-7, 1-Hydroxymethyl-3-cyclopentene, and friends who are interested can also refer to it.

Reference:
Patent; ARBUTUS BIOPHARMA CORPORATION; MENDEZ, Patricia; SYMONDS III, William T.; DIETERICH, Douglas; (290 pag.)WO2019/51257; (2019); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts