Category: 17701-61-0

Application of 17701-61-0, Adding some certain compound to certain chemical reactions, such as: 17701-61-0, name is Benzyl 3-hydroxy-2,2-dimethylpropanoate,molecular formula is C12H16O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17701-61-0.

(a) To a solution of 4-isopropyl-6-hydroxy-2-(1-phenyl-3-trifluoromethylpyrazol-5-yl-oxymethyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide (1 g; 2.08 mmol) in THF containing (Ph)3 P (550 mg; 2.09 mmol) and DEAD (360 mg; 2.07 mmol) was added benzyl 2,2-dimethyl-3-hydroxypropionate (440 mg;2.099 mmol) and the resulting mixture was stirred at room temperature for 15 hours. The mixture was concentrated in vacuo and the residue was purified by flash chromatography (silica gel) to afford 440 mg (32%) of 4-isopropyl-6-[2-(phenylmethyloxycarbonyl-2-methyl)propoxy]-2-(1-phenyl-3-trifluoromethylpyrazol-5-yl-oxymethyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide (Formula I: R1 =Ph; R2 =CF3; R3 =H; R4 =CH(CH3)2; R5 =6-OCH2 C(CH3)2 CO2 CH2 Ph) as a gum.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17701-61-0, Benzyl 3-hydroxy-2,2-dimethylpropanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sanofi; US5750550; (1998); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17701-61-0, name is Benzyl 3-hydroxy-2,2-dimethylpropanoate, molecular formula is C12H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 17701-61-0

tert-Butyl phthalate (5.38 g) was dissolved in toluene (50 ml). To this solution were successively added triethylamine (3.7 ml) and diphenylphosphoryl azide (5.7 ml) and the mixture was heated to 130C and stirred for 1 hr. The reaction mixture was allowed to cool to room temperature and 3-hydroxy-2,2-dimethylpropionic acid benzyl ester obtained in Example 1-4 a) (4.95 g) was added. The mixture was stirred at room temperature for 17 hr. The reaction mixture was diluted with ethyl acetate (50 ml), washed successively with water (50 ml) and saturated aqueous sodium chloride solution (5 ml), dried and concentrated under reduced pressure. The obtained oily substance was purified by silica gel column chromatography (n-hexane/ethyl acetate=1:1). The oily substance (3.28 g) after purification was dissolved in dichloromethane (30 ml). This solution was cooled to 0C and trifluoroacetic acid (30 ml) was added. The mixture was heated to room temperature and stirred for 3 hr. The reaction mixture was concentrated under reduced pressure, after which water (50 ml) was added, and the mixture was extracted with ethyl acetate (150 ml). The organic layer was washed successively with water (50 ml×3) and saturated aqueous sodium chloride solution (50 ml), dried and concentrated under reduced pressure. The obtained oily substance was purified by column chromatography to give the title compound (2.54 g, yield 89%) as a colorless oil.1H-NMR(delta, 300MHz, DMSO-d6) 1.22(6H,s),4.20(2H,s), 5.13(2H,s),7.12(1H,m),7.25-7.34 (5H,m),7.60(1H,m), 7.99(1H,dd,J=1.6,7.9Hz),8.23(1H,d,J=7.9Hz),10.72(1H,s),13.63(1 H,brs).

With the rapid development of chemical substances, we look forward to future research findings about 17701-61-0.

Reference:
Patent; Japan Tobacco Inc.; EP1452526; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 17701-61-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17701-61-0, name is Benzyl 3-hydroxy-2,2-dimethylpropanoate. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 4-hydroxybenzaldehyde (2.7 g), benzyl hydroxypivalate (4.7 g) and triphenylphosphine (6.4 g) in tetrahydrofuran (22 mL) was added diethyl azodicarboxylate (40% toluene solution, 11 mL), and the mixture was stirred at room temperature for 2 days. The reaction mixture was poured into water, and the resulting mixture was extracted with diethyl ether. The organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate = 6/1 – 4/1) to give the title compound (0.97 g).1H-NMR (CDCl3) delta ppm: 1.36 (6H, s), 4.07 (2H, s), 5.15 (2H, s), 6.9-7.0 (2H, m), 7 . 2-7 . 35 (5H, m), 7.75-7.85 (2H, m), 9.89 (1H, s)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17701-61-0, Benzyl 3-hydroxy-2,2-dimethylpropanoate.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1544208; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17701-61-0, name is Benzyl 3-hydroxy-2,2-dimethylpropanoate, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

[91] A solution of diisopropylazodicarboxylate (DIAD, 0.52 mL, 2.8 mmol) prepared in 2 mL anhydrous THF) was slowly added to a stirred mixture of benzyl 3-hydroxy-2,2- dimethylpropanoate (590 mg, 2.8 mmol), triphenylphosphine (820 mg, 3.1 mmol) and N- hydroxyphthalimide (510 mg, 3.1 mmol) prepared in 20 mL anhydrous THF at 0 C. After stirring the mixture at room temperature under a nitrogen atmosphere for 24 h, THF was removed under reduced pressure and the residue re-dissolved in 40 mL of ethyl acetate. The ethyl acetate mixture was washed with water (10 mL) three times, brine and dry-loaded onto a 40-g silica column. The final product was obtained in 73% yield (730 mg) as a white solid after FCC purification (hexane/ethyl acetate). [92] NMR (CDCh, 400 MHz): 5 7.84 (m, 2H), 7.76 (s, 2H), 7.39 (m, 5H), 5.19 (s, 2H), 4.32 (s, 2H), 1.42 (s, 6H); 13C NMR (CDC13, 100 MHz): 5 175.0, 163.1, 136.0, 134.4, 129.0, 128.5, 128.1, 123.5, 83.6, 66.7, 43.2, 22.2, MS (ESI+): m/z (intensity), 354.4 ([M+H]+, 100%).

The synthetic route of 17701-61-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; HU, Longqin; ALOYSIUS, Herve; (59 pag.)WO2018/144880; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts