Synthetic Route of 17701-61-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 17701-61-0, name is Benzyl 3-hydroxy-2,2-dimethylpropanoate. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 4-hydroxybenzaldehyde (2.7 g), benzyl hydroxypivalate (4.7 g) and triphenylphosphine (6.4 g) in tetrahydrofuran (22 mL) was added diethyl azodicarboxylate (40% toluene solution, 11 mL), and the mixture was stirred at room temperature for 2 days. The reaction mixture was poured into water, and the resulting mixture was extracted with diethyl ether. The organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: n-hexane/ethyl acetate = 6/1 – 4/1) to give the title compound (0.97 g).1H-NMR (CDCl3) delta ppm: 1.36 (6H, s), 4.07 (2H, s), 5.15 (2H, s), 6.9-7.0 (2H, m), 7 . 2-7 . 35 (5H, m), 7.75-7.85 (2H, m), 9.89 (1H, s)
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 17701-61-0, Benzyl 3-hydroxy-2,2-dimethylpropanoate.
Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1544208; (2005); A1;,
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