Category: 4064-06-6

Krishnan, Nithiyanandan; Perumal, Devanathan; Atchimnaidu, Siriki; Harikrishnan, Kaloor S.; Golla, Murali; Kumar, Nilima Manoj; Kalathil, Jemshiya; Krishna, Jithu; Vijayan, Dileep K.; Varghese, Reji published the artcile< Galactose-Grafted 2D Nanosheets from the Self-Assembly of Amphiphilic Janus Dendrimers for the Capture and Agglutination of Escherichia coli>, Related Products of 4064-06-6, the main research area is galactose grafted 2D nanosheet selfassembly Janus dendrimer Escherichia agglutination; 2D materials; amphiphiles; bacterial capture; fluorescence; self-assembly.

High aspect ratio, sugar-decorated 2D nanosheets are ideal candidates for the capture and agglutination of bacteria. Herein, the design and synthesis of two carbohydrate-based Janus amphiphiles that spontaneously self-assemble into high aspect ratio 2D sheets are reported. The unique structural features of the sheets include the extremely high aspect ratio and dense display of galactose on the surface. These structural characteristics allow the sheet to act as a supramol. 2D platform for the capture and agglutination of E. coli through specific multivalent noncovalent interactions, which significantly reduces the mobility of the bacteria and leads to the inhibition of their proliferation. Our results suggest that the design strategy demonstrated here can be applied as a general approach for the crafting of biomol.-decorated 2D nanosheets, which can perform as 2D platforms for their interaction with specific targets.

Chemistry – A European Journal published new progress about Agglutination. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Related Products of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghosh, Titli; Mukherji, Ananya; Kancharla, Pavan K. published the artcile< Sterically Hindered 2,4,6-Tri-tert-butylpyridinium Salts as Single Hydrogen Bond Donors for Highly Stereoselective Glycosylation Reactions of Glycals>, Product Details of C12H20O6, the main research area is oligosaccharide preparation sterically hindered butylpyridinium catalyst stereoselective glycosylation glycal.

We demonstrate here that the strained and bulky protonated 2,4,6-tri-tert-butylpyridine salts serve as efficient catalysts for highly stereoselective glycosylations of various glycals. Moreover, the mechanism of action involves an interesting single hydrogen bond mediated protonation of glycals and not via the generally conceived Bronsted acid pathway. The counteranions also play a role in the outcome of the reaction.

Organic Letters published new progress about Glycals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ma, Zhiyuan; Cunningham, Alexander J.; Zhu, X. X. published the artcile< Enzymatic Conversion of Galactose Polymers into Copolymers Containing Galactonic Acid by Glucose Oxidase>, SDS of cas: 4064-06-6, the main research area is copolymer PEG glycopolymer glucose oxidase.

Sugar oxidase can oxidize a carbohydrate substrate into an acid, but there have been no reports on the successful enzymic conversion of glycopolymers containing carbohydrate pendants. We introduced a poly(ethylene glycol) (PEG) spacer between the carbohydrate and the methacrylic units, and glucose oxidase (GOx) showed enzymic activity when the PEG spacer is sufficiently long, converting the galactose pendant into galactonic acid and yielding a copolymer. The glycopolymers with a PEG spacer showed stronger binding to the sugar-specific lectin than those without the spacer, while the binding was gradually weakened as the sugar pendants were converted to acid groups. To the best of our knowledge, this is the first example to use a hydrophilic PEG spacer to enzymically convert a substrate attached on a polymer chain. The enzymic conversion of such glycopolymers represents a useful green chem. approach to obtain copolymers based on carbohydrates.

Biomacromolecules published new progress about Enzymic oxidation. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, SDS of cas: 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Shang-Zheng; Romano, Ciro; Martin, Ruben published the artcile< Site-Selective Catalytic Deaminative Alkylation of Unactivated Olefins>, Category: alcohols-buliding-blocks, the main research area is catalyst deaminative alkylation unactivated olefin.

A catalytic deaminative alkylation of unactivated olefins is described. The protocol was characterized by its mild conditions, wide scope, including the use of ethylene as substrate, and exquisite site-selectivity pattern for both α-olefins and internal olefins, thus unlocking a new catalytic platform to forge sp3-sp3 linkages, even in the context of late-stage functionalization.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Otsuka, Yuji; Yamamoto, Toshihiro; Fukase, Koichi published the artcile< β-Selective Glycosylation by Using O-Aryl-Protected Glycosyl Donors>, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol, the main research area is aryl thioglycoside preparation stereoselective glycosylation aryliodonium triflate; glycosylation; protecting groups; stereoselectivity; synthetic methods; thioglycosides.

New glycosyl donors have been developed that contained several para-substituted O-aryl protecting groups and their stereoselectivity for the glycosylation reaction was evaluated. A highly β-selective glycosylation reaction was achieved by using thioglycosides that were protected by 4-nitrophenyl (NP) groups, which were introduced by using the corresponding diaryliodonium triflate. Anal. of the stereoselectivities of several glycosyl donors indicated that the β-glycosides were obtained through an SN2-type displacement from the corresponding α-glycosyl triflate. The NP group could be removed by reduction of the nitro group and acylation, followed by oxidation with ceric ammonium nitrate (CAN).

Chemistry – An Asian Journal published new progress about Acylation. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Recommanded Product: ((3aR,5R,5aS,8aS,8bR)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-5-yl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Docherty, Jamie H.; Nicholson, Kieran; Dominey, Andrew P.; Thomas, Stephen P. published the artcile< A Boron-Boron Double Transborylation Strategy for the Synthesis of gem-Diborylalkanes>, Product Details of C12H20O6, the main research area is gem alkyl diboronate preparation terminal alkyne borylation hydroborane catalyst; diborylation transborylation mechanism alkyne hydroborane catalyst preparation gem diboronate.

1,1-Diborylalkanes RCH2CH(Bpin)2 were prepared by double borylation of α-alkynes catalyzed by 9-borabicyclononane via transborylation pathway. Olefin hydroboration reactions provide efficient access to synthetically versatile and easily handled organoboronic esters. In this study, we demonstrate that the com. available organoborane reagent 9-borabicyclo[3.3.1]nonane (H-B-9-BBN) can serve as a catalyst for the sequential double hydroboration of alkynes using pinacolborane (HBpin). This strategy, which is effective for a wide range of terminal alkynes, is predicated upon a key C(sp3)-B/B-H transborylation reaction. Transition-state thermodn. parameters and 10-boron-isotopic labeling experiments are indicative of a σ-bond metathesis exchange pathway.

ACS Catalysis published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhuo, Ming-Hua; Wilbur, David J.; Kwan, Eugene E.; Bennett, Clay S. published the artcile< Matching Glycosyl Donor Reactivity to Sulfonate Leaving Group Ability Permits SN2 Glycosylations>, Formula: C12H20O6, the main research area is beta glycosylation sulfonyl leaving group.

Here we demonstrate that highly β-selective glycosylation reactions can be achieved when the electronics of a sulfonyl chloride activator and the reactivity of a glycosyl donor hemiacetal are matched. While these reactions are compatible with the acid- and base-sensitive protecting groups that are commonly used in oligosaccharide synthesis, these protecting groups are not relied upon to control selectivity. Instead, β-selectivity arises from the stereoinversion of an α-glycosyl arylsulfonate in an SN2-like mechanism. Our mechanistic proposal is supported by NMR studies, kinetic isotope effect (KIE) measurements, and DFT calculations

Journal of the American Chemical Society published new progress about Arenesulfonyl chlorides Role: RCT (Reactant), RGT (Reagent), RACT (Reactant or Reagent). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Formula: C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ji, Peng; Zhang, Yueteng; Wei, Yongyi; Huang, He; Hu, Wenbo; Mariano, Patrick A.; Wang, Wei published the artcile< Visible-Light-Mediated, Chemo- and Stereoselective Radical Process for the Synthesis of C-Glyco-amino Acids>, Reference of 4064-06-6, the main research area is homolytic coupling glycoside glycopeptide preparation; stereoselective C glycosylation photoredox catalyzed imine glycopeptide; imino ester chemoselective addition nucleophilic glycosyl radical amino acid.

An approach for efficient synthesis of C-glycosyl amino acids is described. Different from typical photoredox-catalyzed reactions of imines, the new process follows a pathway in which α-imino esters serve as electrophiles in chemoselective addition reactions with nucleophilic glycosyl radicals. The process is highlighted by the mild nature of the reaction conditions, the highly stereoselectivity attending C-C bond formation, and its applicability to C-glycosylations using both armed and disarmed pentose and hexose derivatives

Organic Letters published new progress about Amino acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Reference of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yunqin; Xiang, Guisheng; He, Shaojun; Hu, Yikao; Liu, Yanjun; Xu, Lili; Xiao, Guozhi published the artcile< Orthogonal One-Pot Synthesis of Oligosaccharides Based on Glycosyl ortho-Alkynylbenzoates>, Product Details of C12H20O6, the main research area is glycosylation oligosaccharide synthesis alkynylbenzoate.

One of the most popular one-pot glycosylation strategies is orthogonal one-pot synthesis, which was mainly based on thioglycosides. Despite its successful application, shortcomings of thioglycosides including aglycon transfers, interference of departing species and unpleasant odor restrict its application scope. Herein, we report a new and efficient orthogonal one-pot synthesis of oligosaccharides based on glycosyl ortho-alkynylbenzoate, which solves the issues of thioglycoside-based orthogonal one-pot synthesis. Over a dozen of oligosaccharides have been efficiently synthesized by this method.

Organic Letters published new progress about Glycosides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Denavit, Vincent; Laine, Danny; Bouzriba, Chahrazed; Shanina, Elena; Gillon, Emilie; Fortin, Sebastien; Rademacher, Christoph; Imberty, Anne; Giguere, Denis published the artcile< Stereoselective Synthesis of Fluorinated Galactopyranosides as Potential Molecular Probes for Galactophilic Proteins: Assessment of Monofluorogalactoside-LecA Interactions>, Electric Literature of 4064-06-6, the main research area is stereoselective galactopyranoside galactophilic protein monofluorogalactoside LecA interaction; crystal structure; LecA; NMR spectroscopy; TROSY NMR; carbohydrates; fluorinated glycoside.

The replacement of hydroxyl groups by fluorine atoms on hexopyranoside scaffolds may allow access to invaluable tools for studying various biochem. processes. As part of ongoing activities toward the preparation of fluorinated carbohydrates, a systematic investigation involving the synthesis and biol. evaluation of a series of mono- and polyfluorinated galactopyranosides is described. Various monofluorogalactopyranosides, a trifluorinated, and a tetrafluorinated galactopyranoside have been prepared using a Chiron approach. Given the scarcity of these compounds in the literature, in addition to their synthesis, their biol. profiles were evaluated. Firstly, the fluorinated compounds were investigated as antiproliferative agents using normal human and mouse cells in comparison with cancerous cells. Most of the fluorinated compounds showed no antiproliferative activity. Secondly, these carbohydrate probes were used as potential inhibitors of galactophilic lectins. The first transverse relaxation-optimized spectroscopy (TROSY) NMR experiments were performed on these interactions, examining chem. shift perturbations of the backbone resonances of LecA, a virulence factor from Pseudomonas aeruginosa. Moreover, taking advantage of the fluorine atom, the 19F NMR resonances of the monofluorogalactopyranosides were directly monitored in the presence and absence of LecA to assess ligand binding. Lastly, these results were corroborated with the binding potencies of the monofluorinated galactopyranoside derivatives by isothermal titration calorimetry experiments Analogs with fluorine atoms at C-3 and C-4 showed weaker affinities with LecA as compared to those with the fluorine atom at C-2 or C-6. This research has focused on the chem. synthesis of “”drug-like”” low-mol.-weight inhibitors that circumvent drawbacks typically associated with natural oligosaccharides.

Chemistry – A European Journal published new progress about Antitumor agents. 4064-06-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H20O6, Electric Literature of 4064-06-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts