Category: 28539-02-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H7N3O

To a solution of 2-(4-((1,3-dihydro-2-benzofuran-5-yl)oxy)piperidin-1-yl)-3,4,6-trimethyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one (122 mg, 0.31 mmol) in THF (3 mL) was added LDA (2 M in THF, 0.47 mL, 0.93 mmol) at -78 C. under an atmosphere of nitrogen. After 15 min, a slurry of 1H-benzo[d][1,2,3]triazol-1-yl)methanol (92 mg, 0.62 mmol) in THF (0.5 mL) was added to the reaction at -78 C. and the reaction was aged for 1 h at this temperature. The reaction was quenched with saturated aqueous ammonium chloride and extracted with EtOAc (2×). The combined organic extracts were washed with water (2×), brine, dried (anhydrous sodium sulfate), filtered, and concentrated. The material was purified by silica gel chromatography (10-40% 3:1 EtOAc:EtOH with 1% NH4OH modifier in hexanes) to yield the racemate. The title compounds were resolved by chiral SFC (AD-H column, 40% isopropanol/CO2) to afford isomer 337A (faster eluting, S-isomer): MS: 424 (M+1). 1H NMR (400 MHz, CDCl3): delta 7.15 (1H, d, J=8.0 Hz), 6.82-6.89 (2H, m), 5.06-5.09 (4H, m), 4.20-4.27 (2H, m), 3.62-3.65 (2H, m), 3.48 (2H, br s), 3.11 (5H, br s), 2.64 (3H, s), 2.23 (3H, s), 2.14 (2H, m), 1.99 (2H, m). Isomer 337B (slower eluting, R-isomer): MS: 424 (M+1). 1H NMR (400 MHz, CDCl3): delta 7.86 (1H, s), 7.71 (1H, s), 6.71 (1H, d, J=9.02 Hz), 4.38 (1H, s), 4.32 (1H, s), 4.19 (2H, br s), 3.90 (3H, d, J=2.29 Hz), 3.80 (1H, t, J=9.41 Hz), 3.53 (4H, br s), 3.14 (4H, br s), 2.31 (3H, s), 2.11 (2H, br s), 1.94 (2H, br s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 28539-02-8, 1-(Hydroxymethyl)benzotriazole.

Reference:
Patent; BAO, JIANMING; GAO, XIAOLEI; KNOWLES, SANDRA L.; LI, I, CHUNSING; LO, MICHAEL MAN-CHU; MAZZOLA, Jr., ROBERT D.; ONDEYKA, DEBRA L.; STAMFORD, ANDREW W.; ZHANG, FENGQI; (214 pag.)US2017/183342; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 28539-02-8 ,Some common heterocyclic compound, 28539-02-8, molecular formula is C7H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methylfuro[3,4- b]pyridin-5(7H)-one (70 mg, 0.197 mmol) in THF (3 mL) was added LDA (2.5 M in THF, 0.095 mL, 0.236 mmol) at -78 C under a nitrogen atmosphere. The reaction was stirred at -78 C for 15 min before (1H-benzo[d][1,2,3]triazol-1-yl)methanol (29.4 mg, 0.197 mmol) was added. After 30 min the reaction was quenched with aqueous ammonium chloride (saturated, 5 mL) and was extracted with DCM (10 mL x 3). The combined organic layers were concentrated and purified by reverse phase HPLC (ACN/water with 0.1% NH3OH modifier) to afford the title compound. MS: 386 (M+1).1H NMR (400 MHz, methanol-d4): delta 7.84 (1H, d, J = 2.8 Hz), 7.79 (1H, s), 7.43 (1H, dd, J = 8.8, 2.8 Hz), 6.76 (1H, d, J = 8.8 Hz), 5.34 (1H, s), 4.52-4.54 (1H, m), 4.16 (1H, dd, J = 12.8, 2.8 Hz), 3.95 (1H, dd, J = 4.0, 0.8 Hz), 3.85 (3 H, s), 3.71-3.73 (2 H, m), 3.28-3.35 (2 H, m), 2.38 (3 H, s), 2.11-2.16 (2 H, m), 1.87-1.92 (2 H, m).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,28539-02-8, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; GAO, Xiaolei; KNOWLES, Sandra, L.; LI, Chunsing; LO, Michael Man-Chu; MAZZOLA, Robert, D., Jr.; ONDEYKA, Debra, L.; (148 pag.)WO2018/118736; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 28539-02-8, 1-(Hydroxymethyl)benzotriazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 28539-02-8, blongs to alcohols-buliding-blocks compound. Product Details of 28539-02-8

(A) N-((1H-Benzo[d][1,2,3]triazol-1-yl)methyl)-N-benzyl-1-phenylmethanamine To a mixture of 1H-benzotriazole-1-methanol (10.06 g) and ethanol (250 mL), dibenzylamine (12.97 mL) was added at room temperature, and the resulting mixture was stirred at room temperature for 1 hour. The solvent was distilled off under reduced pressure, and the precipitate was washed with IPE to obtain the title compound (19.99 g). 1H NMR (300 MHz, DMSO-d6) delta 3.70 (4H, s), 5.58 (2H, s), 7.18-7.46 (11H, m), 7.54 (1H, t, J=7.6 Hz), 7.70 (1H, d, J=8.5 Hz), 8.08 (1H, d, J=8.3 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,28539-02-8, its application will become more common.

Reference:
Patent; Takeda Pharmaceutical Company Limited; HIRAYAMA, Takaharu; FUJIMOTO, Jun; CARY, Douglas Robert; OKANIWA, Masanori; HIRATA, Yasuhiro; (147 pag.)US2017/44132; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 28539-02-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 28539-02-8 as follows.

To a 4 ml ethanol solution of 220 mg of 3-amino-7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoroquinolin-4(1H)-one was added 105 mg of 1H-1,2,3-benzotriazol-1-ylmethanol, followed by overnight stirring at room temperature. Next, 48 mg of sodium borohydride was added to the reaction mixture, followed by stirring for 3 hours. By adding water to the resulting reaction mixture and collecting the insoluble materials by filtration, 100 mg of 7-(cyclohexylamino)-1-(1-ethylpropyl)-6-fluoro-3-(methylamino)quinolin-4(1H)-one was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,28539-02-8, its application will become more common.

Reference:
Patent; Astellas Pharma Inc.; EP1995240; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

Example 439; 1-({trans-4-[({4-[2-(Difluoromethyl)-1H-benzimidazol-1-yl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl} amino)methyl]cyclohexyl}amino)-2-methylpropan-2-ol (100 mg) was dissolved in ethanol (2 mL), and triethylamine (31 mul) and 1H-benzotriazal-1-ylmethanol (82 mg) were added thereto, followed by stirring at room temperature for 2 hours. To the reaction mixture was added lithium borohydride (4.8 mg), followed by further stirring at room temperature for 1 hour. Water (10mL) was added thereto, followed by extraction with ethyl acetate (15 mL) and washing with saturated brine. The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. The residue was purified by amino silica gel column chromatography (hexane:ethyl acetate=70:30) to obtain 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{[trans-4-(5,5-dimethyl-1,3-oxazolidin-3-yl)cyclohexyl]methyl}-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-amine (68 mg) as a white powder.

The synthetic route of 28539-02-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Astellas Pharma Inc.; EP2397479; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 28539-02-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 6-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-2-(4-((1,3- dihydroisobenzofuran-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin- 5-one (1.5 g, 2.32 mmol) in THF (30 mL) was added LiHMDS (1 M, 13.9 mL, 13.89 mmol) and (1H-benzo[d][1,2,3]triazol-1-yl)methanol (0.518 g, 3.47 mmol). The reaction mixture was stirred at -70 C for 1 h before warming to RT. Water (30 mL) was added and the mixture was extracted with ethyl acetate (30 mL x 3). The combined organic fractions were washed with water (60 mL x 3), dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by combiflash (0-40% THF/ petroleum ether) to give the title compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 28539-02-8, 1-(Hydroxymethyl)benzotriazole.

Reference:
Patent; MERCK SHARP & DOHME CORP.; GAO, Xiaolei; KNOWLES, Sandra, L.; LI, Chunsing; LO, Michael Man-Chu; MAZZOLA, Robert, D., Jr.; ONDEYKA, Debra, L.; (148 pag.)WO2018/118736; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, the common compound, a new synthetic route is introduced below. Recommanded Product: 28539-02-8

To tert-butyl ((1S,2S)-2-aminocyclohexyl)carbamate (17-1, 500 mg, 2.33 mmol) in EtOH (30 mL) was added (1H-benzo[d][1,2,3]triazol-1-yl)methanol (17-2, 750 mg, 4.67 mmol) and the resulting mixture was stirred for 3 h. Sodium borohydride (265 mg, 7.00 mmol) was then added and stirring was continued overnight. The reaction mixture was concentrated and then quenched with water. The aqueous phase was extracted with DCM (*3) and the combined organic phases were dried over Na2SO4, filtered, and concentrated. The crude residue was purified by reverse phase RP-C18 column chromatography column eluting with 10 to 100% MeCN in water with 0.1% NH4OH as a modifier to provide the product 25-1 (250 mg, 1.03 mmol, 44% yield) as a white solid. MS [M+H]+=243.2.

The synthetic route of 28539-02-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Novartis AG; BECKWITH, Rohan Eric John; BONAZZI, Simone; CERNIJENKO, Artiom; MA, Fupeng; WARE, Nathaniel F.; US2020/16143; (2020); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 28539-02-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, molecular formula is C7H7N3O, molecular weight is 149.15, as common compound, the synthetic route is as follows.

Preparation Example 144 To a mixture of 5-(piperidin-4-yl)-1,3-thiazol-2-amine hydrochloride (519 mg), dichloromethane (5 mL), and methanol (5 mL), 1H-benzotriazol-1-ylmethanol (423 mg), sodium acetate (388 mg), and sodium triacetoxy borohydride (1.0 g) in that order were added followed by stirring at room temperature for 2 hours. To the reaction mixture, a saturated aqueous sodium hydrogen carbonate solution and basic silica gel were added followed by concentration of the solvent under reduced pressure. The resulting residue was purified by basic silica gel column chromatography (chloroform/methanol) to give 5-(1-methylpiperidin-4-yl)-1,3-thiazol-2-amine (411 mg).

The chemical industry reduces the impact on the environment during synthesis 28539-02-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; KOTOBUKI PHARMACEUTICAL CO., LTD.; Astellas Pharma Inc.; Kameda, Minoru; Kuriwaki, Ikumi; Iikubo, Kazuhiko; Hisamichi, Hiroyuki; Kawamoto, Yuichiro; Moritomo, Hiroyuki; Suzuki, Tomoyuki; Futami, Takashi; Suzuki, Atsushi; Tsunoyama, Kazuhisa; Asaumi, Makoto; Tomiyama, Hiroshi; Noda, Atsushi; Iwai, Yoshinori; Tokuzaki, Kazuo; Okada, Haruki; Miyasaka, Kozo; US2014/142084; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole. This compound has unique chemical properties. The synthetic route is as follows. name: 1-(Hydroxymethyl)benzotriazole

To a solution of methyl 2-(2-(4-((6-methoxypyridin-3-yl)oxy)piperidin-1-yl)-3-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)acetate (40 mg, 0.094 mmol) in THF (2 mL) was added lithium bis(trimethylsilyl)amide (47.1 mg, 0.281 mmol) dropwise at -70 C. After stirring for 15 min, a solution of (1H-benzo[d][1,2,3]triazol-1-yl)methanol (21.0 mg, 0.141 mmol) in THF (0.5 mL) was added dropwise and then stirred for 30 min at -70 C. The reaction was quenched with saturated aqueous NH4Cl (0.5 mL), treated with water (10 mL) and the mixture was extracted with EtOAc (20 mL*3). The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by prep-TLC (100% EtOAc) to give the title compound. MS: 457 (M+1).

With the rapid development of chemical substances, we look forward to future research findings about 28539-02-8.

Reference:
Patent; BAO, JIANMING; GAO, XIAOLEI; KNOWLES, SANDRA L.; LI, I, CHUNSING; LO, MICHAEL MAN-CHU; MAZZOLA, Jr., ROBERT D.; ONDEYKA, DEBRA L.; STAMFORD, ANDREW W.; ZHANG, FENGQI; (214 pag.)US2017/183342; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H7N3O

(2) The hydroxymethyl benzotriazole 7.4g added to a single-necked flask,Dropping 25ml SOCl2,After the dropwise addition and stirring 30min,80 reflux 3h;Excess amount of SOCl2 was distilled off by a rotary evaporator,Get white crystals,Namely chloromethyl benzotriazole;

With the rapid development of chemical substances, we look forward to future research findings about 28539-02-8.

Reference:
Patent; Henan Zhong Medical School; Wang Xia; Song Ning; Yuan Juan; Zhang Chao; Zhang Shuling; Yang Huaixia; (10 pag.)CN106188103; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts