Synthetic Route of 28539-02-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 6-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-2-(4-((1,3- dihydroisobenzofuran-5-yl)oxy)piperidin-1-yl)-3-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin- 5-one (1.5 g, 2.32 mmol) in THF (30 mL) was added LiHMDS (1 M, 13.9 mL, 13.89 mmol) and (1H-benzo[d][1,2,3]triazol-1-yl)methanol (0.518 g, 3.47 mmol). The reaction mixture was stirred at -70 C for 1 h before warming to RT. Water (30 mL) was added and the mixture was extracted with ethyl acetate (30 mL x 3). The combined organic fractions were washed with water (60 mL x 3), dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by combiflash (0-40% THF/ petroleum ether) to give the title compound.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 28539-02-8, 1-(Hydroxymethyl)benzotriazole.
Reference:
Patent; MERCK SHARP & DOHME CORP.; GAO, Xiaolei; KNOWLES, Sandra, L.; LI, Chunsing; LO, Michael Man-Chu; MAZZOLA, Robert, D., Jr.; ONDEYKA, Debra, L.; (148 pag.)WO2018/118736; (2018); A1;,
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