Category: 202865-66-5

Electric Literature of 202865-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, molecular formula is C7H6BrFO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 16 (1S,3’R,4’S,5’S,6’R)-6-[(4-ethylphenyl)methyl]-5-fluoro-3′,4′,5′,6′-tetrahydro-6′-(hydroxymethyl)-spiro[isobenzofuran-1(3H),2′-[2H]pyran]-3′,4′,5′-triol [Show Image] [Show Image] 1) Synthesis of 5-bromo-2-fluoro-4-(hydroxymethyl)benzaldehyde; Tetramethylpiperidine (0.68 g, 4.87 mmol) was dissolved in tetrahydofuran (4.5 mL). To the resultant solution was added n-butyllithium (1.0 M n-hexane solution, 4.88 mL) at 0°C, and this solution was stirred for 15 minutes. The resultant mixture was cooled to -78°C and a solution of (2-promo-5-fluorophenyl)methanol (0.50 g, 2.43 mmol) in tetrahydrofuran (2.5 mL) was added dropwise thereto. The temperature of the solution was raised over 2 hours to -40°C. The solution was again cooled to -78°C, and then dimethylformamide (0.47 mL, 6.07 mmol) was added thereto. The temperature of the solution was raised to room temperature, and the solution was stirred for 30 minutes. Saturated aqueous ammonium chloride was then added thereto, and the resultant mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and then concentrated under reduced pressure, to thereby obtain the titled compound (604.3 mg, quantitative). 1H-NMR (CDCl3) delta: 4.78 (2H, s), 7.46 (1H, d, J=10.6 Hz), 8.01 (1H, d, J=6.2 Hz), 10.29 (1H, s).

According to the analysis of related databases, 202865-66-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; EP2048153; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 202865-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, molecular formula is C7H6BrFO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of (2-bromo-5-fluorophenyl) methanol (5g, 0.02 mol) in 1,4-dioxane (60 mL), bis(pinacolato)diboron (5.6 g, 0.022 mol) and potassium acetate (5.6 g, 0.06 mol) were added. The resulting mixture was degassed using a stream of nitrogen and to this was added [U’-bis(diphenylphosphino) ferrocene]dichloropalladium(ll) (250 mg, 0.34 mmol). The reaction mixture was then heated at 80 °C for 10 hrs. The mixture was cooled to room temperature, diluted with H20 and extracted with EtOAc. The organic layer was dried over Na2S04 and evaporated in vacuum to yield (5-fluoro-2-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)methanol (5) that was used in the next reaction step without further purification. Yield-95percent; Purity-99.9percent.

According to the analysis of related databases, 202865-66-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.; PULLAGURLA, Manik Reddy; NANDA KUMAR, Mecheril Valsan; PITTA, Bhaskar Reddy; RANGISETTY, Jagadeesh Babu; (55 pag.)WO2017/183043; (2017); A1;,
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Reference of 202865-66-5, Adding some certain compound to certain chemical reactions, such as: 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol,molecular formula is C7H6BrFO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 202865-66-5.

Example 1; (3’R,4’S,5S,5’S,6’R)-3-[(4-ethylphenyl)methyl]-6′-(hydroxymethyl)-3′,4′,5′,6′-tetrahydrospiro[thieno[2,3,f]isobenzofuran-5(7H),2′-[2H]pyran]-3′,4′,5′-triol; 1) Synthesis of 5-bromo-2-fluoro-4-hydroxymethylbenzaldehyde; [Show Image] Tetramethylpiperidine (0.68 g, 4.87 mmol) was dissolved in tetrahydrofuran (4.5 mL). To the resultant solution was added n-butyllithium (1.0 M n-hexane solution, 4.88 mL) at 0°C, and the solution was then stirred for 15 minutes. The solution was cooled to -78°C, and a solution of (2-bromo-5-fluorophenyl)-methanol (0.50 g, 2.43 mmol) in tetrahydrofuran (2.5 mL) was added dropwise. The temperature of the solution was raised over 2 hours to -40°C. The solution was again cooled to -78°C, and N,N-dimethylformamide (0.47 mL, 6.07 mmol)was added thereto. The temperature of the solution was raised to room temperature, and the solution was then stirred for 30 minutes. Saturated aqueous ammonium chloride was added, and the resultant mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and then concentrated under reduced pressure, to thereby obtain the titled compound (604.3 mg, quantitative). 1H-NMR (CDCl3) delta: 4.78 (2H, s), 7.46 (1H, d, J = 10.6 Hz), 8.01 (1H, d, J = 6.2 Hz), 10.29 (1H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 202865-66-5, (2-Bromo-5-fluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; EP2048152; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 202865-66-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, molecular formula is C7H6BrFO, molecular weight is 205.02, as common compound, the synthetic route is as follows.

General procedure: 2-Halobenzyl tosylates 1a-e were prepared from the corresponding 2-halobenzyl alcohols according to the procedure of Wallace et al.38 p-TsCl (3.2 mmol) was added to a stirred solution of the 2-halobenzyl alcohol (2.7 mmol) in Et2O (15 mL) at 0 C. After addition of freshly powdered KOH (27 mmol) in small portions, the reaction mixture was stirred for 3 h at room temperature. The ethereal solvent was removed in vacuo and the reaction mixture was poured into water (50 mL). The precipitate formed was collected by filtration and purified by flash chromatography over silica gel.

Statistics shows that 202865-66-5 is playing an increasingly important role. we look forward to future research findings about (2-Bromo-5-fluorophenyl)methanol.

Reference:
Article; Omar, Mohamed A.; Conrad, Juergen; Beifuss, Uwe; Tetrahedron; vol. 70; 35; (2014); p. 5682 – 5695;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, the common compound, a new synthetic route is introduced below. Formula: C7H6BrFO

[2-Amino-6-[4-fluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone (?A4?) [0341] 74 mg of (2-bromo-5-fluorophenyl)methanol, 100 mg of potassium carbonate, 1 ml of water and 15 mg of [1,1?-bis(diphenylphosphino)ferrocene]palladium(II) dichloride are added to a solution of 150 mg of [2-amino-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinazolin-4-yl]-(1,3-dihydroisoindol-2-yl)methanone in 3 ml of ethanol under argon. The mixture is heated at 120° C. for min; the hot mixture is filtered through kieselguhr, and the filtrate is evaporated in vacuo. The residue is purified by reverse-phase column chromatography. [0342] Yield: 8 mg (5percent) of [2-amino-6-[4-fluoro-2-(hydroxymethyl)phenyl]quinazolin-4-yl]isoindolin-2-ylmethanone; HPLC retention time: 1.51 min; [0343] 1H NMR (400 MHz, DMSO-d6/TFA-d1) delta [ppm] 8.08-8.02 (m, 2H), 7.81 (d, J=8.7, 1H), 7.42 (d, J=7.2, 1H), 7.39-7.25 (m, 4H), 7.24 (d, J=6.9, 1H), 7.16 (td, J=8.5, 2.8, 1H), 4.99 (s, 2H), 4.82 (s, 2H), 4.36 (s, 2H).

The synthetic route of 202865-66-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG; Eggenweiler, Hans-Michael; Sirrenberg, Christian; Buchstaller, Hans-Peter; US2013/178443; (2013); A1;,
Alcohol – Wikipedia,
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Related Products of 202865-66-5 ,Some common heterocyclic compound, 202865-66-5, molecular formula is C7H6BrFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-bromo-5-fluorophenyl methanol (0.5mmol, 102.0mg),Triphenylmethanol(0.5 mmol, 130.2 mg)And Ph3PAuNTf2(0.015 mmol, 11 mg)Dissolved inOf the 0.5 mL toluene solvent,The reaction mixture was heated to 140 deg.] C with a microwave reactor,The reaction was stirred for 60 minutes,After completion of the reaction,The target product IV was isolated by flash column chromatography,Yield 76percent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 202865-66-5, (2-Bromo-5-fluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenyang Pharmaceutical University; Liu Yongxiang; Cheng Maosheng; Wang Xiaoyu; Du Chuan; Shi Hui; Wang Yanshi; Liu Yang; (8 pag.)CN104817441; (2017); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 202865-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, molecular formula is C7H6BrFO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1)Synthesis of 5-bromo-2-fluoro-4-(hydroxymethyl)benzaldehydeTetramethylpiperidine (0.68 g, 4.87 mmol) was dissolved in tetrahydrofuran (4.5 mL).To the resultant solution was added n-butyllithium (1.0 M n-hexane solution, 4.88 mL) at 0¡ã C., and this solution was stirred for 15 minutes.The resultant mixture was cooled to -78¡ã C. and a solution of (2-bromo-5-fluorophenyl)methanol (0.50 g, 2.43 mmol) in tetrahydrofuran (2.5 mL) was added dropwise thereto.The temperature of the solution was raised over 2 hours to -40¡ã C.The solution was again cooled to -78¡ã C., and then dimethylformamide (0.47 mL, 6.07 mmol) was added thereto.The temperature of the solution was raised to room temperature, and the solution was stirred for 30 minutes.Saturated aqueous ammonium chloride was then added thereto, and the resultant mixture was extracted with ethyl acetate.The organic layer was dried over anhydrous sodium sulfate, and then concentrated under reduced pressure, to thereby obtain the titled compound (604.3 mg, quantitative).1H-NMR (CDCl3) delta: 4.78 (2H, s), 7.46 (1H, d, J=10.6 Hz), 8.01 (1H, d, J=6.2 Hz), 10.29 (1H, s).

According to the analysis of related databases, 202865-66-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; US2011/275703; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts