Sources of common compounds: 3-((4-Methoxybenzyl)oxy)propan-1-ol

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Related Products of 135362-69-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 135362-69-5, name is 3-((4-Methoxybenzyl)oxy)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of the mono-PMB-protected diol (20.56 g, 104.8 mmol, 1.0 equiv) inCH2Cl2 (52 mL) at 0 C was added triethylamine (73.0 mL, 524 mmol, 5.0 equiv), DMSO(52 mL), and SO3pyridine (50.0 g, 314 mmol, 3.0 equiv). After stirring for 1.5 h at 0 C,the reaction was quenched with pH 7 phosphate buffer solution (0.5 M, 800 mL). Theaqueous phase was extracted with Et2O (2 × 400 mL), then EtOAc (2 × 400 mL). Theorganics were washed once with brine, dried over Na2SO4, filtered, and concentrated invacuo. Silica gel chromatography (80:20 to 2:1 hexanes/EtOAc) afforded the titlecompound (14.37 g, 71%), with spectroscopic data in agreement with literature values

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Reference:
Article; Schleicher, Kristin D.; Jamison, Timothy F.; Beilstein Journal of Organic Chemistry; vol. 9; (2013); p. 1533 – 1550;,
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