Category: 100-37-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(Diethylamino)ethanol

165 g of ibuprofen and 160 mL of isopropyl acetate were placed in a pre-dried 500 mL three-necked flask and equipped with a reflux and agitation device; 64 mL of thionyl chloride was slowly added to the three-necked flask with stirring, and the mixture was stirred at room temperature for 30 minutes and then heated to reflux. Keep refluxed for 2-3 hours; The reaction mixture was rotary evaporated until No fraction dropout, and evaporated to dryness by adding 120 mL of n-hexane, and 120 mL of isopropyl acetate was added thereto, and the distillation was continued until no fraction was dropped, and the distillation was repeated once with isopropyl acetate. The evaporated mixture was dissolved in 600 mL of isopropyl acetate and transferred to a pre-dried 2 L three-necked flask, stirred and cooled to below 10 C; 93.6g of 2-(diethylamino)ethanol was slowly added dropwise to the above three necked flask through a constant pressure dropping funnel, and the temperature was controlled within 10 C, after the completion of the dropwise addition, stirring was continued at 0-10 C for 0.5 hours; 88 g of anhydrous potassium carbonate solid was added to the above three-necked bottle in portions, stirred at 5-10 C for 30 minutes, then slowly warmed to 15-25 C, and stirred at this temperature for 8-10 hours; 320 mL of deionized water was added to the above reaction solution, stirred for 15-30 minutes, and the organic phase was separated. The organic phase was washed four times with deionized water (320 mL X 4) and dried over anhydrous sodium sulfate. Filtration, then washed solid sodium sulfate with a small amount of isopropyl acetate; The above organic phase was transferred to a 2L three-necked flask, and the temperature was lowered to below 10 C, and about 32 g of hydrogen chloride gas was introduced at 0-10 C and maintained it for 1- 2 hours, then Concentrated a part of the solution, added 120 mL of n-hexane under stirring, added 1 g of seed crystals, and sealed and placed in refrigerator for crystallization; Filtration, washing with ethyl acetate / n-hexane (V / V = 1:1, 200 ml X 2); The obtained solid was dried under vacuum at 40-50 C until the water (moisture content )is qualified, to obtain 178.56 g of a crystalline crystal, a molar yield of 65.2%, and a purity of 99.76 %.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; Tianjin Xinchen Taifeier Pharmaceutical Technology Co., Ltd.; Yao Chen; (25 pag.)CN108727206; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 100-37-8 ,Some common heterocyclic compound, 100-37-8, molecular formula is C6H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

41 g of ibuprofen was dissolved in 200 ml of ethyl acetate. 16 mL of thionyl chloride was added into the mixture. The mixture was refluxed for 2 h. The mixture was evaporated todryness completely. 500 mL of ethyl acetate was added intothe residue and evaporated off. 500 mL of ethyl acetate wasadded into the reaction mixture. The solution was cooled to 5C. with ice-water bath. 23 g of N,N-diethylaminoethanolwas added into the reaction mixture drop by drop. 40 g ofNaCO was added into the reaction mixture slowly. Themixture was stirred for overnight at RT. 200 mL of water wasadded into the mixture. The ethyl acetate solution was collected and washed with water (3×200 mL) and dried overanhydrous NaSO4. Sodium sulfate was removed by filtration and washed with ethyl acetate (3×100 mL). Anhydrous HCl gas (10 g) was bubbled into the mixture. The solid was collected and washed with ethyl acetate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-37-8, its application will become more common.

Reference:
Patent; TECHFIELDS PHARMA COMPANY LIMITED; YU, CHONGXI; XU, LINA; (113 pag.)JP2018/65866; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 100-37-8, 2-(Diethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

11.7 g of diethylaminoethanol was dissolved in 200 ml of 10% sodium bicarbonate solution and 100 ml of acetone. 31.1 g (0.1 mol) of 5- (2,4-difluorophenyl) acetylsalicyl chloride was added to the reaction mixture. The mixture was stirred at room temperature for 3 hours. The solvent is evaporated. The residue was suspended in 500 ml of ethyl acetate. To the reaction mixture was added 200 ml of 5% sodium bicarbonate. The ethyl acetate layer was collected and washed three times with 500 ml each. The ethyl acetate solution was dried over anhydrous sodium sulfate. The sodium sulfate was removed by filtration. The reaction mixture was stirred with 6 g of acetic acid. The organic phase is evaporated. After drying, 35 g of the desired product was obtained in a yield of 88%.

The synthetic route of 100-37-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yu Chongxi; Techfields Biochem Inc.; Yu, Chongxi; Xu, Lina; (21 pag.)CN105439877; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 100-37-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 100-37-8 as follows.

Preparation of diethylaminoethyl 5-(2,4-difluorophenyl) salicylate.AcOH [39] 11.7 g (0.1 mol) of diethylaminoethanol was dissolved in 10% sodium bicarbonate (200 ml) and acetone (100 ml). 31.1 g (0.1 mol) of 5-(2,4-difluorophenyl) acetylsalicyl chloride was added into the reaction mixture. The mixture is stirred for 3 hours at RT. The solvents are evaporated off. The residue is suspended in ethyl acetate (500ml). 5% sodium bicarbonate (200 ml) is added into the reaction mixture with stirring. Ethyl acetate layer is collected and washed with water ( 3 x 500 ml). The ethyl acetate solution was dried over anhydrous sodium sulfate. Sodium sulfate is removed by filtration. 6 g of acetic acid is added into the reaction mixture with stirring. The organic solution was evaporated off. After drying, it yielded 36 g of the desired product (88%). Hygroscopic product; Solubility in water: 400 mg/ml; Elementary analysis: C H F NO5; MW: 409.42. Calculated % C: 61.60; H: 6.15; F: 9.28; N: 3.42; O: 19.54; Found % C: 61.56; H: 6.18; F: 9.27; N: 3.40; O: 19.59. 1H-NMR (400 MHz, CDCl3): delta: 1.56 (t, 6H), 2.21 (s, 3H), 3.27 (m, 4H), 3.70(m, 2H), 4.69 (t, 2H), 4.9 (b, IH), 6.74 (m, IH), 6.84 (m, IH), 7.0 (b, H), 7.06 (b, IH), 7.15 (m, IH), 7.44 (m, IH), 7.86 (m, IH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-37-8, its application will become more common.

Reference:
Patent; TECHFIELDS BIOCHEM CO. LTD; YU, Chongxi; WO2008/12603; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 100-37-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, molecular weight is 117.1894, as common compound, the synthetic route is as follows.

General procedure: To a solution of phenol (1 equiv), triphenylphosphine (1.3equiv) and 2-(diethylamino)ethanol (1.3 equiv) in THF wasadded diisopropyl azodicarboxylate (DIAD, 1.3 equiv) atambient temperature. After being stirred at ambient temperatureuntil no starting material could be observed byTLC, the reaction mixture was quenched with H2O anddiluted with EtOAc. The organic layer was washed withwater and brine, dried over MgSO4, and concentrated invacuo. Purification of the residue via flash column chromatographyon silica gel afforded the titled compound.

The chemical industry reduces the impact on the environment during synthesis 100-37-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Kim, Seok-Ho; Han, Young Taek; Archives of Pharmacal Research; vol. 38; 11; (2015); p. 1952 – 1962;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 100-37-8, Adding some certain compound to certain chemical reactions, such as: 100-37-8, name is 2-(Diethylamino)ethanol,molecular formula is C6H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100-37-8.

(2R,6S)-tert-Butyl 4-(7-bromo-6-chloro-2-(2-(diethylamino)ethoxy)-8-fluoroquinazolin-4-yl)-2,6-dimethylpiperazine-1-carboxylate To a stirred solution of 2-(diethylamino)ethanol (276 mg, 2.36 mmol) in DMF (20 mL) at RT, NaH (94 mg, 2.36 mmol) was added and the resulting mixture was stirred for 30 min. (2R,6S)-tert-butyl 4-(7-bromo-2,6-dichloro-8-fluoroquinazolin-4-yl)-2,6-dimethylpiperazine-1-carboxylate (600 mg, 1.18 mmol) was added to the reaction mixture and stirred at RT for 2 h. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography on silica gel (MeOH/dichloromethane=40:1) to afford the desired product (140 mg, 20% yield) as a solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 100-37-8, 2-(Diethylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Araxes Pharma LLC; Liu, Yi; Li, Liansheng; Ren, Pingda; (176 pag.)US2018/15087; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 100-37-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 100-37-8 as follows.

General procedure: To a solution of phenol (1 equiv), triphenylphosphine (1.3equiv) and 2-(diethylamino)ethanol (1.3 equiv) in THF wasadded diisopropyl azodicarboxylate (DIAD, 1.3 equiv) atambient temperature. After being stirred at ambient temperatureuntil no starting material could be observed byTLC, the reaction mixture was quenched with H2O anddiluted with EtOAc. The organic layer was washed withwater and brine, dried over MgSO4, and concentrated invacuo. Purification of the residue via flash column chromatographyon silica gel afforded the titled compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-37-8, its application will become more common.

Reference:
Article; Kim, Seok-Ho; Han, Young Taek; Archives of Pharmacal Research; vol. 38; 11; (2015); p. 1952 – 1962;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Into a 250 ml four-necked flask equipped with a stirrer and a water separator and a reflux device, 14.6 g (0.1 mol) of adipic acid, 35.1 g (0.3 mol) of N, N-diethylaminoethanol, (0.2mol) of water, filtered to remove the catalyst (direct reuse), the filtrate transferred to another 250ml of three bottles, vacuum distillation (20ml), the reaction mixture was heated to 150 C, After recovery of the solvent, recovery of excess diethylaminoethanol and recovery of the low boiling point matter, 3.0 g of activated clay was added and stirred for 30 minutes to lower the temperature to 80C or lower.And the filtrate afforded 31.10 g of a di-ethylaminoethyl adipate as a yellow oily liquid in a yield of 90.4%.And then adipic acid bis diethylamino ethanol ester and two times the citric acid mixed with stirring heated to120 C,The citric acid is melted and then cooled and crystallized with stirring to form a salt, thereby obtaining a white powdery solid product of adipic acid bis diethylaminoethanol citrate. Its melting point: 117 C.

According to the analysis of related databases, 100-37-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Suzhou Institute of Science and Technology; Wang, Yanlin; Wang, Hao; Wang, Siyuan; Qiu, Yexian; (13 pag.)CN105801441; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

diethylaminoethyl methacrylate is synthesized by using diethylaminoethanol and methyl methacrylate as raw materials and lithium hydroxide as a catalyst. The process steps are as follows:(1) Synthesis: 300 g (3.0 mol) of methyl methacrylate, 117 g (1.0 mol) of diethylaminoethanol, 10 g of lithium hydroxide and 0.6 g of hydroquinone were added to a 1000 mL with stirring, a thermometer and a vacuum fractionation apparatus. The three-necked flask was heated to 75 C to 85 C, and the temperature at the top of the column was controlled to be 50 C to 55 C. The methanol was continuously separated under a negative pressure of about 600 mmHg, and the reaction was stopped until no methanol was separated (about 3.5 h). Methanol 33.0 g was separated, and gas chromatographic analysis showed that the methanol content was 89.3% and the methyl methacrylate content was 9.6%.(2) Purification: Cool to room temperature and wash twice with 300 mL × 2 of deionized water. The oil phase is gradually depressurized (40-100 mmHg), and unreacted methyl methacrylate and diethylaminoethanol are distilled off at 70 C to 100 C, and then distilled under reduced pressure at 5 to 10 mmHg and 90 C to 100 C. Diethylaminoethyl acrylate. The weight of the obtained mixture of methyl methacrylate and diethylaminoethanol was 195.8 g, and gas chromatographic analysis showed that the methyl methacrylate content was 95.9% and the diethylaminoethanol content was 3.6%. This mixture can be used directly for the synthesis of diethylaminoethyl methacrylate. The weight of the obtained product was 174.1 g (theoretical yield: 185.26 g), and the yield was 94.0%. The gas chromatographic analysis showed that the content of diethylaminoethyl methacrylate was 99.4%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; Sinopec Corporation; Sinopec Corporation Victory Oil Field Fen Corporation Petroleum Engineering Technology Institute; Zhang Songting; Yang Shengli; Bai Xin; Rong Yan; Du Chunan; Chen Xiaochun; Cai Qingjun; Ma Tiantai; Sun Lizhu; Yue Jiwen; (10 pag.)CN108976136; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 100-37-8 ,Some common heterocyclic compound, 100-37-8, molecular formula is C6H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add 146g of thionyl chloride and 240g of dichloromethane to the 1L reaction bottle to cool down, use 500ml beaker during cooling processA mixed solution of 120 g of diethylaminoethanol and 100 g of dichloromethane was prepared. When the temperature in the reaction flask was lowered to -10 C, a mixture of diethylaminoethanol and dichloromethane was added dropwise at a temperature of -10 to 20 C. 1 hour and 28 minutes, the addition is completed;After the completion of the dropwise addition, the temperature was raised to 20 to 45 C for 5 hours, and after the completion of the incubation, the dichloromethane was concentrated for 1 hour and 05 minutes.Concentrated to a total of 258g of dichloromethane, the recovery of dichloromethane can be directly applied;After concentration and drying, the temperature was lowered to 27 C. 240 g of absolute ethanol was added to the reaction flask and heated to dissolve the solid.After dissolving, the ice brine was cooled to -5 to -10 C for 6 hours, and filtered to obtain 2-diethylaminochloroethane hydrochloride wet product 177.6 g wet.Product.After the mother liquor is collected, 208g of ethanol is concentrated and recovered. The recovered ethanol can be continuously applied, and the residual liquid is placed in a freezer for freezing and crystallization. After hourly filtration, 18.5 g of the mother liquor product was obtained, and then recrystallized from 32 g of recovered ethanol to obtain 13.8 g of a qualified mother liquor. A total of 191.4 g of the combined product was dried at 55-60 C to obtain 173.9 g of dry product of 2-(diethylamino)ethyl chloride hydrochloride, and the liquid phase purity was 99.82%, and the molar yield was calculated to be 98.7%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-37-8, its application will become more common.

Reference:
Patent; Shandong Cheng Hui Shuang Da Pharmaceutical Co., Ltd.; Wang Yongguang; Liu Xuewen; Xue Qimeng; Zhao Zhonggui; Xu Linjie; (9 pag.)CN108084033; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts