Category: 100-37-8

Adding a certain compound to certain chemical reactions, such as: 100-37-8, 2-(Diethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 100-37-8, blongs to alcohols-buliding-blocks compound. 100-37-8

Reference example 81 2-(2-Diethylaminoethoxy-9-tetrahydropyranyladenine 2-Diethylaminoethanol (30ml) was gradually dropped to sodium hydride (0.96g, 40mmol) under a nitrogen atmosphere at 0C over a 15 minutes period. Then the mixture was warmed to room temperature and stirred for 20 minute. 2-Chloro-9-tetrahydropyranyladenine (1.0g, 3.9mmol) which was prepared in Reference example 80 was added thereto and the mixture was stirred at 100C for 1.5 hours.

With the rapid development of chemical substances, we look forward to future research findings about 100-37-8.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; AstraZeneca AB; EP1728792; (2006); A1;,
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100-37-8, Adding a certain compound to certain chemical reactions, such as: 100-37-8, 2-(Diethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 100-37-8, blongs to alcohols-buliding-blocks compound.

To a mixture of benzyl 4-[2-methylsulfinyl-7-[5-methyl-l-(2- trimethylsilylethoxymethyl)indazol-4-yl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4- yl]piperazine-l-carboxylate (500 mg, 739 umol) and 2-(diethylamino)ethanol (173 mg, 1.48 mmol, 197 uL) in THF (10 mL) was added t-BuONa (213 mg, 2.22 mmol), and the mixture stirred at 20 C for 1 hour under N2 atmosphere. The mixture was cooled to 0 C and HCl (2 M) was added until pH~7. The mixture was filtered and the filtrate was concentrated in vacuo. The residue was purified by column chromatography using 0- 10% MeOH/DCM as eluent to give impure material which was further purified by reversed phase chromatography to give benzyl 4- [2-[2-(diethylamino)ethoxy]-7-[5-methyl-l-(2-trimethylsilylethoxymethyl)indazol-4-yl]-6,8- dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]piperazine-l-carboxylate (220 mg, 295 umol, 39.9 % yield). ES+APCI MS m/z 729.3 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-37-8, its application will become more common.

Reference:
Patent; MIRATI THERAPEUTICS, INC.; ARRAY BIOPHARMA, INC.; FISCHER, John, P.; FELL, Jay, Bradford; BLAKE, James, F.; HINKLIN, Ronald, Jay; MEJIA, Macedonio, J.; HICKEN, Erik, James; CHICARELLI, Mark, Joseph; GAUDINO, John, J.; VIGERS, Guy, P.A.; BURGESS, Laurence, E.; MARX, Matthew, Arnold; CHRISTENSEN, James, Gail; LEE, Matthew, Randolf; SAVECHENKOV, Pavel; ZECCA, Henry, J.; (529 pag.)WO2017/201161; (2017); A1;,
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The common heterocyclic compound, 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 100-37-8

A mixture of 4-bromoacetophenone (5g, 25 mmol), the diethylaminoethanol (3.5g, 38 mmol), K2CO3 (2g), copper powder (0.5g) and copper (I) iodide (2.5g) in DMSO (30 ML) was heated at 120C until TLC showed consumption of the starting material. After cooling to RT, the mixture was poured onto aqueous NH3 (28 %, 100 ML), extracted with CH2CL2 (3 x 100 ml). The combined organic extracts were dried (NA2SO4), filtered and the CH2CL2 distilled in vacuo. The crude product was purified by column chromatography on silica gel, eluting with EtOAc-MeOH (95: 5) to furnish the pure compound (4.85g, 82%).

The synthetic route of 100-37-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CYTOPIA PTY LTD; WO2003/99811; (2003); A1;,
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Adding some certain compound to certain chemical reactions, such as: 100-37-8, name is 2-(Diethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100-37-8. 100-37-8

EXAMPLE 24D 5-[6-[3-(2-Diethylamino-ethoxy)-phenyl]-pyridazin-3-yl]-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic Acid Tert-Butyl Ester To a solution of the product of Example 24C (0.1 g, 0.26 mmol) and N,N-diethylethanolamine (Aldrich, 87 mL, 0.65 mmol) in 10 mL CH2Cl2 at 0 C. was added polymer-supported triphenylphosphine (Aldrich, 3 mmol/gram, 0.65 mmol, 0.22 g). The diisopropyl azodicarboxylate (DIAD, Aldrich, 0.13 mL, 0.65 mmol) was added dropwise via syringe and, following the addition, the ice-bath was removed and the reaction mixture stirred at ambient temperature for 2 h. The mixture was then filtered, concentrated and purified via column chromatography (SiO2, 1% NH4OH:9% CH3OH:90% CH2Cl2) to give 0.12 g of the title compound (0.25 mmol, 96% yield). MS (DCI/NH3) m/z 482 (M+H)+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 100-37-8.

Reference:
Patent; Basha, Anwer; Bunnelle, William H.; Dart, Michael J.; Gallagher, Megan E.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Ryther, Keith B.; Tietje, Karin R.; US2005/65178; (2005); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 100-37-8

1. Synthesis of diethyl-[2-(2-methyl-[1,10]phenanthrolin-4-yloxy)-ethyl]amine To a suspension of sodium hydride (60% in mineral oil, 5.25 g, 131.1 mmol) in anhydrous THF (90 mL) a solution of N,N-diethyl-2-hydroxyethylamine (15.30 g, 131.1 mmol) in anhydrous THF (60 mL) was slowly added. The mixture was stirred at room temperature for 20 minutes and a solution of 4-chloro-2-methyl-[1,10]phenanthroline(6.00 g, 26.2 mmol) in anhydrous THF (90 mL) was slowly added. The reaction mixture was refluxed for 18 hours and then allowed to cool down to room temperature, quenched with 1 N HCl and evaporated. The residue was redissolved in 1N NaOH (150 mL) and extracted with methylene chloride (3 x 200 mL). The combined organic layers were dried (Na2SO4), filtered and concentrated in vacuo. The residue was washed with hexane and purified by flash chromatography (SiO2, MeOH/DCM, 1:40) to yield the pure product as an orange oil (5.1 g, 63%).

The chemical industry reduces the impact on the environment during synthesis 100-37-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOSCIRA, S.A.; EP2002863; (2008); A1;,
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100-37-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100-37-8, name is 2-(Diethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

180 g of 2-acetylsalicylic acid,And dissolved in 1000 ml of chloroform.The mixture was cooled to 5 C. 103 g of 1,3-Dicyclohexylcarbodiimide was added to the mixture.The mixture was stirred at room temperature for 2 hours. Solid waste is filtered out,It was washed with chloroform (3 ¡Á 300 ml).59 g of diethylaminoethanol was added to the reaction mixture.The mixture was stirred at room temperature for 3 hours. The organic solution was evaporated.After drying 220 g of the desired product was obtained (96%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; Yu, Chauncy; Tech Fields Inc.; Schuh, Rina; (73 pag.)JP2017/105853; (2017); A;,
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100-37-8, Adding a certain compound to certain chemical reactions, such as: 100-37-8, 2-(Diethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 100-37-8, blongs to alcohols-buliding-blocks compound.

34.9 g (0.1 mol) of 4- [1- (5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl) ethenyl] benzoic acid (bexarotene; Targretin )) Was dissolved in 300 ml of chloroform.To this reaction mixture was added 20.6 g of N, N’-dicyclohexylcarbodiimide.11.6 g of dimethylaminoethanol was added to the reaction mixture. The mixture was stirred at room temperature for 3 hours. Solids were removed by filtration.The chloroform solution was washed with 5% NaHCO 3 (2 ¡Á 10 0 ml) and water (3 ¡Á 100 ml).The organic solution was dried over anhydrous sodium sulfate.Sodium sulfate was removed by filtration. To this reaction mixture 3.6 g of HCl gas / ether (100 ml) was added with stirring. The solid product was collected by filtration. After drying 40 g of the desired product (85.8%) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-37-8, its application will become more common.

Reference:
Patent; YU, CHONGXI; (76 pag.)JP2017/160261; (2017); A;,
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100-37-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below.

A mixture of 2,7-diiodofluoren-9-one (4.32 g, 10.0 mmol; see J. Chem. Res. (S) 1999, 590), 2-diethylaminoethanol (1.35 mL, 10.2 mmol; Aldrich), copper(I) iodide (190 mg, 1.0 mmol; Aldrich), 1,10-phenanthroline (360 mg, 2.0 mmol; Aldrich) and powdered cesium carbonate (6.5 g, 20 mmol; Aldrich) in dry toluene (10 mL) was heated under nitrogen to 110 C. with vigorous stirring for 24 h. After cooling to room temperature, the reaction mixture was filtered through diatomaceous earth, rinsing with CH2Cl2, and concentrated. The residue was dissolved in CH2Cl2, washed with aq. NaOH, and purified by flash chromatography (120 g silica gel, 1-10% gradient of NH4OH-MeOH (1:10) in CH2Cl2) to provide the title compound (1.85 g, 4.39 mmol; 44% yield): 1H NMR (300 MHz, CDCl3) delta 7.90 (d, J=2 Hz, 1H), 7.76 (dd, J=8, 2 Hz, 1H), 7.39 (d, J=8 Hz, 1H), 7.14-7.22 (m, 2H), 7.00 (dd, J=8, 2 Hz, 1H), 4.11 (br s, 2H), 2.52-3.05 (m, 6H), 1.10 (t, J=7 Hz, 6H); MS (DCl/NH3): m/z 422 (M+1)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 100-37-8, 2-(Diethylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Schrimpf, Michael R.; Sippy, Kevin B.; Ji, Jianguo; Li, Tao; Frost, Jennifer M.; Briggs, Clark A.; Bunnelle, William H.; US2005/234031; (2005); A1;,
Alcohol – Wikipedia,
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100-37-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below.

General procedure: To tetrahydrofuran (THF) (1 mL) in a microwave reaction vessel were added cyclopentanol (0.067 mL, 0.74 mmol) and NaH (0.040 g, 1.68 mmol). After the reaction mixture was stirred at room temperature for 10 min, 2,6-dichloropyrazine (0.10 g, 0.67 mmol) was added and the resulting reaction mixture was heated in the microwave reactor at power 100 W and 50 C for 10 min. After removal of solvent in vacuo, the residue was treated with ethyl acetate and water mixture. Organic layer was collected and dried over anhydrous sodium sulfate. Removal of solvent in vacuo gave 2-chloro-6-(cyclopentyloxy)pyrazine 0.148 g in quantitative yield;

At the same time, in my other blogs, there are other synthetic methods of this type of compound,100-37-8, 2-(Diethylamino)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Lee, Jinho; Park, Jongseong; Hong, Victor Sukbong; Chemical and Pharmaceutical Bulletin; vol. 62; 9; (2014); p. 906 – 914;,
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100-37-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100-37-8, name is 2-(Diethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of N,N-diethylethanolamine (0.08 g, 0.7 mmol) (Aldrich) in DMF (5 mL) was added sodium hydride (0.028 g, 0.7 mmol). The mixture was stirred at room temperature for 30 minutes, and then 4-chloro-3-[(2-methanesulfonyl-7-oxo-7,8-dihydro-pyrido-pyrido[2,3-d]-pyrimidine-6-carbonyl)-amino]-benzoic acid methyl ester (0.044 g, 0.10 mmol) (from Example 32 supra) was added and the mixture was stirred at room temperature for 18 hours. The mixture was purified by HPLC eluting with MeCN/H2O to give 4-chloro-3-{[2-(2-diethylamino-ethoxy)-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl]-amino}-benzoic acid. (Yield 0.030 g, 65.2%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; Anderson, Kevin; Chen, Yi; Chen, Zhi; Luk, Kin-Chun; Rossman, Pamela Loreen; Sun, Hongmao; Wovkulich, Peter Michael; US2012/184542; (2012); A1;,
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