Category: 50919-06-7

Related Products of 50919-06-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50919-06-7, name is 2-(2-Fluorophenyl)ethanol, molecular formula is C8H9FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 5.1.57.3. Step 3. To a solution of 2-(3-fluorophenyl)ethanol(25.26 g, 180 mmol) in pyridine (180 mL) was added TsCl(36.49 g, 186 mmol) at 0 C with silica gel blue tube. After stirringat rt for 4 h, the reaction was quenched by the addition of 2 N HCl (750 mL) at 0 C. This mixture was extracted with EtOAc (300 mL).The separable organic layer was washed with 2 N HCl (250 mL),H2O (200 mL), brine (100 mL), and dried over MgSO4, filtered, concentratedunder reduced pressure. The residue was purified by columnchromatography (SiO2, n-hexane/EtOAc = 10/1-5/1) to obtain2-(3-fluorophenyl)ethyl 4-methylbenzenesulfonate (38.54 g, 73%)as a colorless oil.

According to the analysis of related databases, 50919-06-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Imaeda, Toshihiro; Ono, Koji; Nakai, Kazuo; Hori, Yasunobu; Matsukawa, Jun; Takagi, Terufumi; Fujioka, Yasushi; Tarui, Naoki; Kondo, Mitsuyo; Imanishi, Akio; Inatomi, Nobuhiro; Kajino, Masahiro; Itoh, Fumio; Nishida, Haruyuki; Bioorganic and Medicinal Chemistry; vol. 25; 14; (2017); p. 3719 – 3735;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 50919-06-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50919-06-7, name is 2-(2-Fluorophenyl)ethanol, molecular formula is C8H9FO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1.02 g of p-toluensulfonyl chloride (5.35 MM), 1.24 ml of diisopropyl ethylamine (7.13 mmol) and 86mg OF 4- (DIMETHYLAMINO) pyridine (0.71 mmol) were added to the reaction solution (3.57 mmol) containing 500 mg of 2- (2-fluoro-phenyl)- ethanol (3.57 mmol) dissolved in methylene chloride solution with stirring for 6 hrs at 0 C under Ar atmosphere, and then the reaction mixture was stirred for 12hrs at room temperature. The resulting mixture was neutralized with ammonium chloride, extracted with ethyl acetate and washed with saturated NACI solution to separate into an organic layer and water layer. The organic layer was dried over anhydrous MgS04, filtered and concentrated in vacuo. The resultant was purified by Silica gel column chromatography with a solvent mixture mixed with methanol and chloroform (1: 7) as an eluant to give 740 mg of TOLUEN-4-SULFONATE-2- (2-FLUORO-PHENYL)-ETHYL ester (u) (yield : 70%).

According to the analysis of related databases, 50919-06-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Korea Research Institute of Bioscience and Biotechnology; WO2004/101523; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts