Category: 150192-39-5

Application of 150192-39-5 ,Some common heterocyclic compound, 150192-39-5, molecular formula is C8H9BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(2-Bromo-5-methoxyphenyl)methanol (1 eq.) was dissolved in anhydrous DMF (1.1M solution) and imidazole (1.05 eq.) was added. To the stirred solution triisopropylsilyl chloride (1.1 eq.) was added and the resulting mixture was left stirring at RT for 8 h. All volatiles were evaporated in vacuo and the residual material was filtered with PE / EtOAc (9:1) over a pad of silica gel. After evaporation in vacuo the product was obtained as a colorless oil (94%), which was used without further characterization in the next reaction.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,150192-39-5, its application will become more common.

Reference:
Patent; ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA; WO2007/129119; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 150192-39-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 150192-39-5, name is (2-Bromo-5-methoxyphenyl)methanol, molecular formula is C8H9BrO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 2; 2- [(2-Bromo-5-methoxybenzyl) oxy]-7-methoxynaphthalene [0045]; To a solution of 7-methoxy-2-naphthol (26.92 g, 0.15 moles), 2-bromo- 5-methoxybenzyl alcohol (33.58 g, 0.15 moles), and triphenylphosphine (39.3 g, 0.15 moles) in anhydrous THF (500 mls) was added a solution of DEAD (26.10 g, 0.15 moles) in THE (100 mL) dropwise over 0.5 hr. The solution was stirred at room temperature overnight and, upon evaporation of half the volume, the product precipitated in good purity. The solid was filtered and rinsed with THF, then dried to yield 32.96 g (59%) of a white solid: mp 156-157 C ; 1H NMR (DMSO-d6): 6 3.77 (3H, s), 3.86 (3H, s), 5.18 (2H, s), 6.92 (1H, dd, J=3. 2 Hz, J=8. 7 Hz), 7.00 (1H, dd, J=2. 4 Hz, J=8. 7 Hz), 7.09 (1H, dd, J=2. 4 Hz, J=8. 9 Hz), 7.22 (1H, d, J=3. 2 Hz), 7.25 (1H, d, J=2. 4 Hz), 7.35 (1H, d, J=2. 4 Hz), 7.59 (1H, d, J=8. 7 Hz), 7.74 (1H, d, J=8. 7 Hz), 7.76 (1H, d, J=8. 7 Hz); MS mlz 373/375 ( [M+H] +). Anal. for ClsHl7BrO3 : Calc’d: C: 61.14 ; H: 4.59 Found: C: 61.29 ; H: 4.21

According to the analysis of related databases, 150192-39-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; WYETH; WO2005/82880; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 150192-39-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 150192-39-5, name is (2-Bromo-5-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Preparative Example 91 Preparation of 5-methoxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole 2-bromo-5-methoxybenzylalcohol (6.5 parts; 0.03M) was dissolved in dry THF (100 ml) and cooled to -78 C. n-Butyl-lithium (26.4 ml of a 2.5M solution in hexanes ex Aldrich, 0.066M) was added over 20 minutes with stirring under a nitrogen blanket and keeping the temperature below -60 C. After stirring for a further hour at -70 C. HPLC showed the reaction to be incomplete with 20% starting material remaining. A further aliquot of n-butyl-lithium in hexanes (5 ml; 0.0125M) was added and the reactants allowed to warm to -50 C. Tributylborate (17.8 ml; 0.066M) was then added at between -70 and -50 C. with stirring under a nitrogen blanket and the reactants allowed to warm to about 20 C. Water (20 ml) was added and the pH adjusted to 10 with hydrochloric acid. After washing with diethylether, the pH of the aqueous phase was adjusted to pH 1-2 with hydrochloric acid and washed with diethyl ether. The ether extract was washed with aqueous saturated brine, dried over anhydrous magnesium sulphate and the ether evaporated to leave the product as a pale oil (3.7 parts). This was slurried with water containing a little methanol whereupon a pinkish-white solid separated which was filtered, washed with water and dried (2.0 parts) mp=110-115 C. after recrystallisation from aqueous methanol.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 150192-39-5, (2-Bromo-5-methoxyphenyl)methanol.

Reference:
Patent; Zeneca Limited; US5880188; (1999); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 150192-39-5, name is (2-Bromo-5-methoxyphenyl)methanol, molecular formula is C8H9BrO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: (2-Bromo-5-methoxyphenyl)methanol

Dissolve (2-bromo-5-methoxy-phenyl) -methanol (5.0 g, 23 mmol) in dry dichloromethane (120 mL) and cool to 0 [C] under nitrogen. Add ethyl vinyl ether (2.5 g, [34 MMOL)] followed by [PYRIDINIUMP-TOLUENESULFONATE (580] mg, 2.3 mmol). Warm to room temperature and stir for 2 hours. Pour reaction into saturated aqueous sodium bicarbonate and extract twice with dichloromethane. Combine organic layers and wash with water and brine. Dry with sodium sulfate, filter and concentrate in vacuo to yield 6.6 g (100%) of title compound as a clear colorless [OIL.’H] NMR [(CDC13)] 8 7.41 (d, J= 8.6 Hz, 1H), 7. 08 (d, [J =] 3.1 Hz, 1H), 6.71 (dd, J= 8.8, 3.1 Hz, 1H), 4. [88] (q, J= 5.3 Hz, 1H), 4.65 (ab, Jab = 13.3 Hz, H), 4.55 (ab, Jab = 13.3 Hz, 1H), 3.8 (s, 3H), 3.71 (m, [1H),] 3.55 (m, [1H),] 1.41 (d, [J=] 5.3 Hz, 3H), 1.23 (t, [J=] 7.0 Hz, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 150192-39-5.

Reference:
Patent; ELI LILLY AND COMPANY; WO2004/9578; (2004); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 150192-39-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 150192-39-5, name is (2-Bromo-5-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Dissolve 18 (MW 217.06, 47.2 mmol, 10.24 g) in 55 mL CH2Cl2 and cool to -200 C. Add diispropylethylamine, DIEA, (MW 129.25, d 0.742, 1.3 equ, 10.69 mL) then methane sulfonyl chloride (MsCl) (MW 114.55, d 1.480, 1.2 equ, 4.38 mL). Age -50 C. to 00 C. for 1 h then quench into 55 mL water. Extract with CH2Cl2 then wash with 1N H2SO4 (40 mL), then brine. Dry organic layers (magnesium sulfate) and concentrate in vacuo to afford 19 (MW 295.15, 13.23 g) in 95% yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 150192-39-5, (2-Bromo-5-methoxyphenyl)methanol.

Reference:
Patent; Merck & Co., Inc.; US6353110; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 150192-39-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 150192-39-5, name is (2-Bromo-5-methoxyphenyl)methanol, molecular formula is C8H9BrO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step C 2-Bromo-5-methoxybenzaldehyde Pyridinium Chlorochromate (1.2 eq) was added to a solution of 2-bromo-5-methoxybenzyl alcohol (1 eq) and Celite (1.2 eq) in methylene chloride (0.30 M) at RT and the resulting mixture was stirred under nitrogen for 3 h. The mixture was filtered through a plug of silica rinsing with methylene chloride and concentrated in vacuo to give 2-bromo-5-methoxy benzaldehyde as a white solid. EI-MS m/z 232, 234 (M+NH4)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 150192-39-5, (2-Bromo-5-methoxyphenyl)methanol.

Reference:
Patent; Amgen Inc.; US6514964; (2003); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts