100-83-4 Archives - Alcohols-buliding-blocks

Suman, S.’s team published research in Chemica Sinica in 2020 | CAS: 100-83-4

3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Safety of 3-Hydroxybenzaldehyde

《Lemon juice as an efficient biocatalyst for one pot three component green synthesis of substituted 5-amino-1-(2,4-dinitrophenyl)-1h-pyrazole-4-carbonitriles》 was published in Chemica Sinica in 2020. These research results belong to Suman, S.; Singh, Rajvir; Gulati, Susheel; Suprita. Safety of 3-Hydroxybenzaldehyde The article mentions the following:

An eco-friendly one pot three component green synthesis of substituted 5-amino-1-(2,4-dinitrophenyl)-1H-pyrazole-4-carbonitriles I (R1 = H, Cl, OH; R2 = H, OH, NO2; R3 = H, Cl, Me, OMe, OH) have been carried out in presence of lemon juice as a recyclable catalyst. The use of biocatalysts is focused on eco-friendly organic synthesis. Here, lemon juice, which is an inexpensive, safe and eco-friendly catalyst in the one pot three components reaction of aryl aldehydes 2-R1-3-R2-4-R3-C6H2CHO, malononitrile and 2,4-dinitrophenyl hydrazine for the synthesis of pyrazole derivatives I under mild conditions have been showed. After optimization of reaction conditions for synthesis of pyrazoles I (R1 = R2 = H; R3 = OMe), it was found that 4.0mL of lemon juice gave 82% yield in 1.4 h at room temperature in solvent-free conditions. This novel and eco-friendly pathway has the merits of high yield, simple handling and benign synthesis. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Claassen, C.’s team published research in ChemCatChem in 2020 | CAS: 100-83-4

《Benchtop NMR for Online Reaction Monitoring of the Biocatalytic Synthesis of Aromatic Amino Alcohols》 was published in ChemCatChem in 2020. These research results belong to Claassen, C.; Mack, K.; Rother, D.. Recommanded Product: 3-Hydroxybenzaldehyde The article mentions the following:

Online analytics provides insights into the progress of an ongoing reaction without the need for extensive sampling and offline anal. In this study, we investigated benchtop NMR as an online reaction monitoring tool for complex enzyme cascade reactions. Online NMR was used to monitor a two-step cascade beginning with an aromatic aldehyde and leading to an aromatic amino alc. as the final product, applying two different enzymes and a variety of co-substrates and intermediates. Benchtop NMR enabled the concentration of the reaction components to be detected in buffered systems in the single-digit mM range without using deuterated solvent. The concentrations determined via NMR were correlated with offline samples analyzed via uHPLC and displayed a good correlation between the two methods. In summary, benchtop NMR proved to be a sensitive, selective and reliable method for online reaction monitoring in (multi-step) biosynthesis. In future, online analytic systems such as the benchtop NMR devices described might not only enable direct monitoring of the reaction, but may also form the basis for self-regulation in biocatalytic reactions. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 3-Hydroxybenzaldehyde)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jahan, Khorshada’s team published research in PLoS One in 2021 | CAS: 100-83-4

Jahan, Khorshada; Khan, Kaif Rashid; Akhter, Kawsari; Romman, Umme Kulsum Rowzatur; Halim, Ershad published their research in PLoS One in 2021. The article was titled 《A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study》.Related Products of 100-83-4 The article contains the following contents:

A convenient approach to synthesis 3-m-tolyl-5-arylidene-2,4-thiazolidinediones (TZDs) I [R = 3-OH, 2-MeO, 2-Cl, 3-Cl, 2-2ON] derivatives in two steps with moderate to good yield using morpholine as a catalyst was reported. All the structures I were confirmed by their spectral IR, 1H NMR and 13C NMR data. The anti-diabatic activity of all synthesized mols. I was evaluated by docking with peroxisome proliferator-activated receptor-γ (PPARγ). Preliminary flexible docking studies revealed that compounds I [R = 3-OH, 2-MeO, 4-Cl] showed better binding affinity with the protein and could be a potential candidate for the treatment of type 2 diabetes in near future. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxybenzaldehyde(cas: 100-83-4Related Products of 100-83-4)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maleki, Behrooz’s team published research in Polyhedron in 2019 | CAS: 100-83-4

3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Category: alcohols-buliding-blocks

The author of 《SO3H-dendrimer functionalized magnetic nanoparticles (Fe3O4@D-NH-(CH2)4-SO3H): Synthesis, characterization and its application as a novel and heterogeneous catalyst for the one-pot synthesis of polyfunctionalized pyrans and polyhydroquinolines》 were Maleki, Behrooz; Reiser, Oliver; Esmaeilnezhad, Ehsan; Choi, Hyoung Jin. And the article was published in Polyhedron in 2019. Category: alcohols-buliding-blocks The author mentioned the following in the article:

In this study, novel SO3H-dendrimer functionalized magnetic nanoparticles (Fe3O4@D-NH-(CH2)4-SO3H) were prepared and characterized by using FT-IR, X-ray diffraction patterns, SEM, transmission electron microscopy, thermogravimetry anal., and energy-dispersive X-ray spectroscopy. The synthesized nanosized catalyst was successfully applied to the synthesis of highly substituted pyrans and polyhydroquinolines via a straightforward one-pot multicomponent condensation reaction. The key advantages are the short reaction time, high yields, simple workup, and purification of products by simple recrystallization from ethanol. The experimental process involved the reaction of 3-Hydroxybenzaldehyde(cas: 100-83-4Category: alcohols-buliding-blocks)

Referemce:
Alcohol – Wikipedia,
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Adibian, Fatemeh’s team published research in Polyhedron in 2020 | CAS: 100-83-4

ãOne-pot synthesis of dihydro-1H-indeno[1,2-b] pyridines and tetrahydrobenzo[b] pyran derivatives using a new and efficient nanocomposite catalyst based on N-butylsulfonate-functionalized MMWCNTs-D-NH2ã?was written by Adibian, Fatemeh; Pourali, Ali Reza; Maleki, Behrooz; Baghayeri, Mehdi; Amiri, Amirhassan. Product Details of 100-83-4 And the article was included in Polyhedron in 2020. The article conveys some information:

In this study, magnetic multi-walled carbon nanotubes were functionalized with polyamidoamine (PAMAM) dendrimers and modified with butylsulfonate to afford MMWCNTs-D-(CH2)4-SO3H. The synthesized nanocomposite (MMWCNTs-D-(CH2)4-SO3H) was characterized by various techniques such as Fourier transform IR spectroscopy (FT-IR), transmission electron microscopy (TEM), SEM, XRD and thermo-gravimetric anal. (TGA). This nanocomposite catalyst effectively catalyzed four and three component reactions for the synthesis of dihydro-1H-indeno[1,2-b]pyridines I [R = H, 4-Me, 4-OMe, etc.] and tetrahydrobenzo[b]pyrans II [R1 = R2 = H, Me] (85-98% yield in 15-20 min and 80-98% yield in 12-30 min, resp.). In addition, the magnetically recoverable catalyst could be easily recycled at least five times without significant loss of catalytic activity. In the first step of synthesis of nanocomposite the Fe3O4 nanoparticles were deposited on oxidized MWCNTs, then a modified PAMAM dendrimer was used to bond to the carbonyl groups. Finally MMWCNTs-D-NH2 functionalized with 1,4-butanesultone. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Product Details of 100-83-4) was used in this study.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kappauf, Katrin’s team published research in ChemBioChem in 2021 | CAS: 100-83-4

Kappauf, Katrin; Majstorovic, Nikola; Agarwal, Seema; Rother, Dorte; Claassen, Christiane published an article in 2021. The article was titled ãModulation of Transaminase Activity by Encapsulation in Temperature-Sensitive Poly(N-acryloyl glycinamide) Hydrogelsã? and you may find the article in ChemBioChem.Safety of 3-Hydroxybenzaldehyde The information in the text is summarized as follows:

Smart hydrogels hold much potential for biocatalysis, not only for the immobilization of enzymes, but also for the control of enzyme activity. We investigated upper critical solution temperature-type poly N-acryloyl glycinamide (pNAGA) hydrogels as a smart matrix for the amine transaminase from Bacillus megaterium (BmTA). Phys. entrapment of BmTA in pNAGA hydrogels results in high immobilization efficiency (>89%) and high activity (97%). The temperature-sensitiveness of pNAGA is preserved upon immobilization of BmTA and shows a gradual deswelling upon temperature reduction While enzyme activity is mainly controlled by temperature, deactivation tended to be higher for immobilized BmTA (=62-68%) than for free BmTA (=44%), suggesting a deactivating effect due to deswelling of the pNAGA gel. Although the deactivation in response to hydrogel deswelling is not yet suitable for controlling enzyme activity sufficiently, it is nevertheless a good starting point for further optimization. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jadhav, Chetan K.’s team published research in ACS Omega in 2019 | CAS: 100-83-4

Computed Properties of C7H6O2In 2019 ,ãEfficient Rapid Access to Biginelli for the Multicomponent Synthesis of 1,2,3,4-Tetrahydropyrimidines in Room-Temperature Diisopropyl Ethyl Ammonium Acetateã?was published in ACS Omega. The article was written by Jadhav, Chetan K.; Nipate, Amol S.; Chate, Asha V.; Songire, Vishal D.; Patil, Anil P.; Gill, Charansingh. H.. The article contains the following contents:

The diisopropyl Et ammonium acetate (DIPEAc)-promoted Biginelli protocol has been developed for the first time by a successive one-pot three-component reaction of aldehydes, ethylcyanoacetate/ethyl acetoacetate, and thiourea/urea to afford pharmacol. promising 1,2,3,4-tetrahydropyrimidines in high yields at room temperature The key benefits of the present scheme are the capability to allow a variability of functional groups, short reaction times, easy workup, high yields, recyclability of the catalyst, and solvent-free conditions, thus providing economic and environmental advantages. In addition, a series of 4-oxo-6-aryl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitriles analogs were synthesized and selected for their in vitro antifungal and antibacterial activities. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Computed Properties of C7H6O2)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Safajoo, Nasrin’s team published research in RSC Advances in 2019 | CAS: 100-83-4

Application In Synthesis of 3-HydroxybenzaldehydeIn 2019 ,ãFe3O4@nano-cellulose/Cu(II): a bio-based and magnetically recoverable nano-catalyst for the synthesis of 4H-pyrimido[2,1-b]benzothiazole derivativesã?appeared in RSC Advances. The author of the article were Safajoo, Nasrin; Mirjalili, Bi Bi Fatemah; Bamoniri, Abdolhamid. The article conveys some information:

Fe3O4@nano-cellulose/Cu(II) as a green bio-based magnetic catalyst was prepared through in situ co-precipitation of Fe2+ and Fe3+ ions in an aqueous suspension of nano-cellulose. The mentioned magnetically heterogeneous catalyst was characterized by FT-IR, XRD, VSM, FESEM, TEM, XRF, EDS and TGA. In this research, the synthesis of 4H-pyrimido[2,1-b]benzothiazole derivatives I (R = 4-Cl, 2-NO2, 3,4-(OH)2, etc.) was developed via a three component reaction of aromatic aldehydes RC6H4CHO, 2-aminobenzothiazole and Et acetoacetate using Fe3O4@nano-cellulose/Cu(II) under solvent-free condition at 80 °C. Some advantages of this protocol are good yields, environmentally benign, easy work-up and moderate reusability of the catalyst. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)

Referemce:
Alcohol – Wikipedia,
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Torabi, Morteza’s team published research in RSC Advances in 2021 | CAS: 100-83-4

Recommanded Product: 100-83-4In 2021 ,ãSynthesis of new pyridines with sulfonamide moiety via a cooperative vinylogous anomeric-based oxidation mechanism in the presence of a novel quinoline-based dendrimer-like ionic liquidã?appeared in RSC Advances. The author of the article were Torabi, Morteza; Yarie, Meysam; Zolfigol, Mohammad Ali; Rouhani, Shamila; Azizi, Shohreh; Olomola, Temitope O.; Maaza, Malik; Msagati, Titus A. M.. The article conveys some information:

In the present study, the synthesis of a novel quinoline-based dendrimer-like ionic liquid I was reported. After characterization of the mentioned ionic liquid with suitable techniques such as Fourier transform IR spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDX), elemental mapping, thermogravimetric anal. (TGA) and derivative thermogravimetry (DTG), its catalytic performance was investigated in the synthesis of new pyridines with sulfonamide moiety II (R = Ph, 2-chlorophenyl, thiophen-2-yl, etc.) and III via a cooperative vinylogous anomeric-based oxidation mechanism under mild reaction conditions. All target mols. II ad III were achieved in short reaction times and high yields. After reading the article, we found that the author used 3-Hydroxybenzaldehyde(cas: 100-83-4Recommanded Product: 100-83-4)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Taheri, Maryam’s team published research in BMC Chemistry in 2022 | CAS: 100-83-4

In 2022,Taheri, Maryam; Aslani, Samira; Ghafouri, Hossein; Mohammadi, Asadollah; Akbary Moghaddam, Vaha; Moradi, Nastarn; Naeimi, Hananeh published an article in BMC Chemistry. The title of the article was ãSynthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors on PC12 cellsã?Formula: C7H6O2 The author mentioned the following in the article:

The loss of cholinergic neurotransmission in Alzheimerâ²s disease (AD) patientsâ?brain is accompanied by a reduced concentration of Acetylcholine (ACh) within synaptic clefts. Thus, the use of acetylcholinesterase inhibitors (AChEIs) to block the cholinergic degradation of ACh is a promising approach for AD treatment. In the present study, a series of 2-chloro-3-hydrazinopyrazine derivatives (CHP1-5) were designed, synthesized, and biol. evaluated as potential multifunctional anti-AD agents. In addition, the chem. structures and purity of the synthesized compounds were elucidated through using IR, 1H and 13C NMR, and elemental analyses. Further, the intended compounds were assessed in vitro for their AChE inhibitory and neuroprotective effects. Furthermore, DPPH, FRAP and ABTS assays were utilized to determine their antioxidant activity. The statistical anal. was performed using one-way ANOVA. Based on the results, CHP4 and CHP5 exhibited strong AChE inhibitory effects with the IC50 values of 3.76 and 4.2 Î¼M compared to the donepezil (0.53 Î¼M), resp. The study examined the effect and mol. mechanism of CHP4 on the Ab1-42-induced cytotoxicity in differentiated PC12 cells. At concentrations of 0-100 Î¼M, CHP4 was non-toxic in PC12. Addnl., Ab1-42 significantly stimulated tau hyperphosphorylation and induced differentiated PC12 cell death. Further, CHP4 resulted in diminishing the Ab1-42-induced toxicity in PC12 cell significantly. CHP4 at 30 Î¼M concentration significantly increased the Ab1-42-induced HSP70 expression and decreased tau hyperphosphorylation. According to the results of our studies CHP4 can be considered as safe and efficient AChEI and employed as a potential multifunctional anti-AD agent. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Formula: C7H6O2)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts