《Lemon juice as an efficient biocatalyst for one pot three component green synthesis of substituted 5-amino-1-(2,4-dinitrophenyl)-1h-pyrazole-4-carbonitriles》 was published in Chemica Sinica in 2020. These research results belong to Suman, S.; Singh, Rajvir; Gulati, Susheel; Suprita. Safety of 3-Hydroxybenzaldehyde The article mentions the following:
An eco-friendly one pot three component green synthesis of substituted 5-amino-1-(2,4-dinitrophenyl)-1H-pyrazole-4-carbonitriles I (R1 = H, Cl, OH; R2 = H, OH, NO2; R3 = H, Cl, Me, OMe, OH) have been carried out in presence of lemon juice as a recyclable catalyst. The use of biocatalysts is focused on eco-friendly organic synthesis. Here, lemon juice, which is an inexpensive, safe and eco-friendly catalyst in the one pot three components reaction of aryl aldehydes 2-R1-3-R2-4-R3-C6H2CHO, malononitrile and 2,4-dinitrophenyl hydrazine for the synthesis of pyrazole derivatives I under mild conditions have been showed. After optimization of reaction conditions for synthesis of pyrazoles I (R1 = R2 = H; R3 = OMe), it was found that 4.0mL of lemon juice gave 82% yield in 1.4 h at room temperature in solvent-free conditions. This novel and eco-friendly pathway has the merits of high yield, simple handling and benign synthesis. In addition to this study using 3-Hydroxybenzaldehyde, there are many other studies that have used 3-Hydroxybenzaldehyde(cas: 100-83-4Safety of 3-Hydroxybenzaldehyde) was used in this study.
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Safety of 3-Hydroxybenzaldehyde
Referemce:
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Alcohols – Chemistry LibreTexts