Category: 37585-25-4

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 37585-25-4, name is (2-Amino-5-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H8ClNO

General procedure: To an oven-dried 15 mL sealed tube were added 2-aminophenylmethanol 1 (0.425 mmol), benzonitrile 2(0.25 mmol), Ru cat. b (1.94 mg, 1 mol%), and KOtBu (14.02 mg, 0.5equiv) intamyl alcohol (1 mL) under an air atmosphere. The sealedtube was capped and heated at 130C for 2 h. The reaction mixturewas cooled down to room temperature and directly concentratedunder vacuum. The crude mixture was puried by preparative thin-layer-chromatography (petroleum ether/ethyl acetate 20/1) togive the desired product 3 or 4.

With the rapid development of chemical substances, we look forward to future research findings about 37585-25-4.

Reference:
Article; Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji; Tetrahedron; vol. 75; 18; (2019); p. 2697 – 2705;,
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Related Products of 37585-25-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37585-25-4, name is (2-Amino-5-chlorophenyl)methanol, molecular formula is C7H8ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of 2-amino-5-chlorophenylmethanol (11.1g, 70.4mmol) in tetrahydrofuran (50mL) was added imidazole (5.27g, 77.5mmol), followed by careful addition of terf-butyldimethylchlorosilane (10.62g, 70.4mmol). The reaction mixture was stirred for 24 hours. Imidazole (528mg, 7.75mmol) and tert-butyldimethylchlorosilane (1.06g, 7.03mmol) were then added. After 1 hour the solid was filtered off and washed with diethyl ether (2 x 20ml_) and the filtrate was washed with water (10mL), brine (10ml_), dried over magnesium sulfate and concentrated in vacuo to give the product as a brown oil, 18.83g (98%).1H NMR (400 MHz, CDCI3): 5 0.07 (6H, s), 0.90 (9H, s), 4.63 (2H, s), 6.60 (1H, d), 7.01 (1H, d), 7.05 (1H, m); LRMS: m/z APCI+272[MH+].

According to the analysis of related databases, 37585-25-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2006/21882; (2006); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.37585-25-4, name is (2-Amino-5-chlorophenyl)methanol, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.Recommanded Product: (2-Amino-5-chlorophenyl)methanol

General procedure: To a solution of 1a (1.2 g, 7.61 mmol) in CH2Cl2 (20 mL) was added MnO2 (2.6 g, 30.1 mmol) and stirred at rt under an Ar atmosphere. After 23 h with stirring, the reaction mixture was filtrated and evaporated. The residue was crystallized from AcOEt to give 7a (1.0 g, 85%) as a yellow needle crystal.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,37585-25-4, (2-Amino-5-chlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi; Bioorganic and Medicinal Chemistry; vol. 20; 19; (2012); p. 5810 – 5831;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 37585-25-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37585-25-4, name is (2-Amino-5-chlorophenyl)methanol, molecular formula is C7H8ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Benzyl alcohol derivative 11 (1 eq.) was dissolved in CH2Cl2 (0.4 M). Manganese (IV) oxide (2.1 eq.)was added under argon and the solution was left to stir at room temperature for 48 h. The progress ofthe reaction was monitored by TLC analysis. After completion, manganese oxide was filtered off andthe resulting filtrate was concentrated under reduced pressure. The crude product was purified by silicacolumn chromatography employing mixtures of n-hexane and ethyl acetate as eluents to obtain thedesired product 10.

According to the analysis of related databases, 37585-25-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Jarrige, Lucie; Merad, Jeremy; Zaied, Siwar; Blanchard, Florent; Masson, Geraldine; Synlett; vol. 28; 14; (2017); p. 1724 – 1728;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 37585-25-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 37585-25-4, name is (2-Amino-5-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Oxidation of (2-amino-phenyl)-methanols (3) to 2-amino-benzaldehydes (4) -General procedure; [0082] (2-Amino-phenyl)-methanol (12 mmol) in dry diethyl ether (25 ml_) is added dropwise to a mixture of manganese dioxide (48 mmol) in dry diethyl ether (25 ml_) and the mixture is stirred at rt overnight. The solution is filtered through a celite and the solvent is removed at reduced pressure. The crude product is used in the next step without further purification.; 2-Amino-5-crtloro-benzaldehyde; Yield 99%; 1H NMR (CDCI3): 6.14 (br s, 2H); 6.61 (d, 9 Hz, 1 H); 7.25 (dd, 9 and 2 Hz, 1 H); 7.44 (d, 2 Hz, 1 H) and 9.80 (s, 1 H).

According to the analysis of related databases, 37585-25-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERZ PHARMA GMBH & CO KGAA; HENRICH, Markus; BAUER, Angela; NAGAL, Jens; SLADEK, Meik; PARSONS, Christopher, Graham, Raphael; DANYSZ, Wojciech; KRAUSS, Valerjans; ROZHKOVS, Jevgenijs; STARCHENKOVS, Igors; TRIFANOVA, Dina; WO2010/37533; (2010); A1;,
Alcohol – Wikipedia,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.37585-25-4, name is (2-Amino-5-chlorophenyl)methanol, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.Application In Synthesis of (2-Amino-5-chlorophenyl)methanol

To 40 ml of DMS0 in the reactor, PdCl2 (dppf), organic ligand L1, potassium carbonate and an auxiliary agent, And 12 mmol of the compound of formula (I) and 18 mmol of the compound of formula (II) in the above reaction scheme, with nitrogen being inert to formAtmosphere, sealed reaction at 110 C for 5 hours, the reaction is completed by natural cooling, vacuum concentration, the use of petroleum ether and ethyl acetate(1: 2 by volume) as the eluent to give the compound of the above formula (III) in a yield of96.7%;[0053] wherein the molar amount of the PdCl2 (dppf) is 1.2% by mol of the compound of the formula (I), and the ligand LlIs used in an amount of 3% by mol based on the molar amount of the compound of formula (I), the molar amount of said potassium carbonate being a molar amount of the compound of formula (I)35% and the molar amount of said auxiliary PhSiH3 is 1.5% by mol based on the compound of formula (I).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,37585-25-4, (2-Amino-5-chlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Wang, Wenming; (10 pag.)CN104557737; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts