Category: 112-27-6

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 112-27-6

j00524j A solution of triethylene glycol (30 g, 199.7 mmol) in THF (300 mL) wascooled to 0C and charged with NaOH (11.98 g, 299.7 mmol) and stirred for 15 mm. Thissolution was charged with tosyl chloride (38.07 g, 199.7 mmol) and stirred at room temperature for 2 h. The reaction mixture was concentrated in vacuo and the residue obtained was dilutedwith water (100 mL) and extracted with ethyl acetate (3 X 200 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo resulting in acrude compound which was purified by chromatography on silica gel, eluting with 2%methanol in DCM to give 18.5 g, 30% yield of the title compound as a colorless oil. ?H NMR(400 MHz, CDC13): oe = 7.78 (d, J= 8.3 Hz, 2H), 7.33 (d, J= 8.1 Hz, 2H), 4.25 -4.10 (m, 2H),3.75 – 3.60 (m, 6H), 3.63 – 3.52 (m, 4H), 2.43 (s, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 112-27-6.

Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 112-27-6, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2,2′-(Ethane-1,2-diylbis(oxy))diethanol

Compound triethylene glycol (5.0g, 33.3mmol) was dissolved in 10mL of dichloromethane, Et3N (6.7g, 66.6mmol) was added, TsCl (8.9g, 46.6mmol) was added dropwise under ice-dichloromethane solution. After completion of the dropwise addition, the mixture was transferred to room temperature and stirred for 12 hours. After adjusting the pH of the solution to 6 with 6M HCl, 10 mL of water was added, and the mixture was extracted three times with 30 mL of dichloromethane, and the organic phases were combined and dried over anhydrous sodium sulfate. Column chromatography (EA) gave 7.5 g of a yellow liquid product with a yield of 74%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,112-27-6, its application will become more common.

Reference:
Patent; Hangzhou Oulian Pharmaceutical Technology Co., Ltd.; Zhang Xingxian; (22 pag.)CN109928956; (2019); A;,
Alcohol – Wikipedia,
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Synthetic Route of 112-27-6 , The common heterocyclic compound, 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, molecular formula is C6H14O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 6-1 (235 g, 1.57 mol) was dissolved in 500 mL of tetrahydrofuran, then potassium hydroxide (41.2 g, 0.57 mmol, 82% w/w) was added, and then p-toluenesulfonyl chloride 6-2 (100 g, 0.52 mol) was added in batches, and the mixture was stirred at room temperature for 5 hours. The reaction solution was poured into 1200 mL of water, and extracted with ethyl acetate (400 mL*3). The extract liquid was combined and washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure and purified by silica gel column chromatography, with an eluent (petroleum ether:ethyl acetate=1:1), to obtain the target product 6-3 (118 g, 75%) as a colorless oil. LC-MS: m/z=305[M+H]+.

The synthetic route of 112-27-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenzhen China Resources Gosun Pharmaceutical Co., Ltd.; Jiang, Xiongjie; Huang, Quanhua; Yang, Zhanao; (43 pag.)US2017/2028; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 112-27-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. A new synthetic method of this compound is introduced below.

Triethylene glycol (30 g, 0.2 mol) was dissolved in a solution of NaOH (8 g in 8 mL of H2O) and stirred for 10 min. Then benzyl chloride (7 mL, 0.062 mol) was added and the reaction mixture was heated to 100 C. and stirred overnight. The crude reaction was diluted with sat NaCl (500 mL), washed CH2Cl2 (2×400 mL), organic layers dried MgSO4, and evaporated to dryness. Column chromatography (silica, ethyl acetate to ethyl acetate/MeOH, 10:1) afforded 1 a yellowish oil (9.87 g, 67% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, and friends who are interested can also refer to it.

Reference:
Patent; James, Kenneth D.; US2008/207505; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 112-27-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows.

Add 1 mmol of triethylene glycol to the three-necked flask,Add 1 mmol of pyridine,Dissolve with 20 ml of dichloromethane.Stir in a 0 oC ice bath.Dissolve 1 mmol of p-methylbenzenesulfonyl chloride with dichloromethane.Slowly drip into three-necked flask.The reaction was washed with hydrochloric acid after 3 h,The organic layer was washed with water until the aqueous solution was neutral.Drying with anhydrous sodium sulfate,Column chromatography yielded the product.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol.

Reference:
Patent; Gannan Normal University; Wu Yongquan; Zeng Guanjie; Wu Renmiao; Fan Xiaolin; (15 pag.)CN105061515; (2017); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 112-27-6, Adding some certain compound to certain chemical reactions, such as: 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol,molecular formula is C6H14O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112-27-6.

triethylene glycol single-ended p-toluenesulfonic acid ester synthesis: lmmol of triethylene glycol into the three-necked burningThe flask was filled with ImmoL pyridine, dissolved in 20 mL of dichloromethane and stirred in an ice bath at 0 C. ImmoL p-toluenesulfonyl chloride dissolved in dichloromethane was slowly added dropwise. After 3 hours, the reaction was washed with hydrochloric acid, and the organic layer was washed with water until the aqueous solution became neutral. Dried over anhydrous sodium sulfate, and separated by column chromatography.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Gannan Normal University; Wu, Yongquan; Fan, Xiaolin; Ceng, Guanjie; Wu, Renmiao; Jiang, Tianyu; Li, Yibao; (11 pag.)CN105601675; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H14O4

Polyethylene glycol (9 g, 60 mmol) was dissolved in 70 mL of toluene,Then, 10.2 mL of 48% HBr aqueous solution was added, heated to reflux,With sodium bicarbonate to absorb the release of gas,The reaction temperature was controlled at 115 C and the reaction was stirred for 3 days.After cooling, the reaction mixture was neutralized with saturated aqueous sodium bicarbonate and then solvent was removed. 30 mL of water was added and extracted with CH 2 Cl 2 (3 × 60 mL).The combined organic phases were dried over anhydrous sodium sulfate, and the organic solvent was stripped to give 5.2 g of compound 15 in 41% yield.

With the rapid development of chemical substances, we look forward to future research findings about 112-27-6.

Reference:
Patent; Shanghai Jiao Tong University; Shen Yumei; Yang Qinglai; Tan Lianjiang; Li Xinhui; Shao Zhifeng; Gong Bing; Li Xiaowei; Liu Yazhi; Zhang Zhen; (35 pag.)CN104725453; (2017); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 112-27-6 , The common heterocyclic compound, 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, molecular formula is C6H14O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Triethylenc glycol (17.5 mL, 19.7 g, 131.13 mmol. 5 eq) was dissolved in DCM (150 mL·} and trimethyiamine (5.48 mL, 3.98 g, 1.5 eq) and cooled to 0. TsCI (5.00 g, 26.23 mmol 1 eq) was then added and die reaction mixture stirred at room temperature tor 18 hours. The reaction was diluted into DCM and washed with water (3x) and brine (lx). The organic layer was dried over sodium sulfate and concentrated in. vacuo. The crude product was purified on silica (0-5% MeOH in DCM) to give compound 64 (6,89 g, 22,6 mmol) in 85% yield. lH NMR (400 MHz, Chloroform-t/) 6 7.80 (d, J – 8.3 Hz, 2H), 7.38 ~ 7.30 (m, 2H)S 4.23 4.14 (m, 2H), 3.71 (id, J = 5.3, 4.3 Hz, 4H), 3.66 – 3.55 (m, 6H), 2.45 (s, 3H). C NMR (101 MHz, cdcl3) 144.98, 133.09, 129,95, 128.09, 72.58, 70.91 , 70.44, 69.28, 68.84, 1.88, 2 /76.

The synthetic route of 112-27-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; YALE UNIVERSITY; SPIEGEL, David; CAIANIELLO, David; (247 pag.)WO2019/199621; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 112-27-6 ,Some common heterocyclic compound, 112-27-6, molecular formula is C6H14O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Triethylene glycol (4.50 g, 30 mmol) and triethylamine (TEA) (8.0 mL) were dissolved in dichloromethane (60 mL). Then, tosylchloride (5.70 g, 30 mmol) was added in one portion. The resulting mixture was stirred for 12 h at 25 oC (Scheme 2). After washing with KHSO4 (1 mol/L, 40 mL) and NaHCO3 (5%, 40 mL) and drying over anhydrous Na2SO4, the crude product was obtained by evaporation and subsequently purified by column chromatography over silica gel (dichloromethane/MeOH = 100:1, v/v) to obtain the target product 1 as a colorless oil (4.2 g, 14.4 mmol, 48%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,112-27-6, its application will become more common.

Reference:
Article; Wu, Xuan; Gao, Lei; Sun, Junzhao; Hu, Xiao-Yu; Wang, Leyong; Chinese Chemical Letters; vol. 27; 11; (2016); p. 1655 – 1660;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 112-27-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 112-27-6 as follows.

To a mixture of Ag2O (12.4 g, 100 mmol) and KI (4.42 g, 26.64 mmol) in DCM (200 mL) was added 2,2?-(ethane-1,2-diylbis(oxy))diethanol (10 g, 66.6 mmol) dropwise at room temperature. Then BnBr (12.5 g, 73.26 mmol) was added dropwise into the mixture over 10 min. After addition, the mixture was stirred at room temperature for 2 h. The reaction mixture was filtered. The combined filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethanol (7 g, 43.8%) as a colorless oil. LC/MS (ESI, m/z): [M+1]+=241.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,112-27-6, its application will become more common.

Reference:
Patent; Kymera Therapeutics, Inc.; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (180 pag.)US2020/10468; (2020); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts