Adding a certain compound to certain chemical reactions, such as: 112-27-6, 2,2′-(Ethane-1,2-diylbis(oxy))diethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 112-27-6, blongs to alcohols-buliding-blocks compound. Application In Synthesis of 2,2′-(Ethane-1,2-diylbis(oxy))diethanol
Compound triethylene glycol (5.0g, 33.3mmol) was dissolved in 10mL of dichloromethane, Et3N (6.7g, 66.6mmol) was added, TsCl (8.9g, 46.6mmol) was added dropwise under ice-dichloromethane solution. After completion of the dropwise addition, the mixture was transferred to room temperature and stirred for 12 hours. After adjusting the pH of the solution to 6 with 6M HCl, 10 mL of water was added, and the mixture was extracted three times with 30 mL of dichloromethane, and the organic phases were combined and dried over anhydrous sodium sulfate. Column chromatography (EA) gave 7.5 g of a yellow liquid product with a yield of 74%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,112-27-6, its application will become more common.
Reference:
Patent; Hangzhou Oulian Pharmaceutical Technology Co., Ltd.; Zhang Xingxian; (22 pag.)CN109928956; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts