Category: 5343-92-0

Synthetic Route of 5343-92-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5343-92-0, name is 1,2-Pentanediol, molecular formula is C5H12O2, molecular weight is 104.1476, as common compound, the synthetic route is as follows.

A generic experiment was as follows. In a two-neck roundbottomflask of 10 mL, 1,2-phenylenediamine (1a, 0.5 mmol),1,2-propyleneglycol (2a, 0.6 mmol), 1.5 mL of diethylene glycol dimethylether (diglyme), and an amount of catalyst were added.Subsequently, the reaction mixture was heated at 140 C in a siliconebath that contains a magnetic stirrer and a temperature controller.

The chemical industry reduces the impact on the environment during synthesis 5343-92-0, I believe this compound will play a more active role in future production and life.

Reference:
Article; Climent; Corma; Hernandez; Hungria; Iborra; Martinez-Silvestre; Journal of Catalysis; vol. 292; (2012); p. 118 – 129;,
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Reference of 5343-92-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5343-92-0, name is 1,2-Pentanediol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of 0.05 mol of acetal 1, 0.055 mol of diol 4a-4e, and 100 mg of toluenesulfonic acid in 50 mL of benzene was heated under reflux, while a fraction containing benzene and ethyl alcohol was distilled off. As distillate was distilled off, fresh solvent was added to the boiling solution. The distillation was carried out until the absence of ethanolin distillate according to gas-liquid chromatography.The reaction mixture was cooled, washed with NaHCO3 solution, dried with Na2SO4, benzene was removed, and the residue was distilled in a vacuum.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5343-92-0, 1,2-Pentanediol.

Reference:
Article; Zlotskii; Raskil?dina; Golovanov; Bormotin; Bekin; Doklady Chemistry; vol. 472; 1; (2017); p. 3 – 6; Dokl. Akad. Nauk; vol. 472; 1; (2017); p. 43 – 46,4;,
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Application of 5343-92-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5343-92-0, name is 1,2-Pentanediol, molecular formula is C5H12O2, molecular weight is 104.1476, as common compound, the synthetic route is as follows.

Prepare 55g sodium hydrogen (2.3mol) under nitrogen protectionAnd a suspension of 200 ml of tetrahydrofuran,Slowly add 1,2-pentanediol 125g (1.2mol) under micro refluxa mixture with 200 ml of tetrahydrofuran,There is a constant flow of gas to produce a discharge system.No gas is produced after stirring for 10 hours.A sodium salt suspension is obtained for use.After replacing the air in the 2000 mL autoclave with nitrogen,After adding 300 ml of tetrahydrofuran under nitrogen protection,Maintain internal temperature -10 ~ 0 C into the sulfuryl fluoride 151.6g (1.48 mol),The sodium salt suspension was continuously added to the kettle, and the reaction was kept for 2 hours.After the reaction, the nitrogen blowing system removes excess sulfuryl fluoride gas.The reaction solution was filtered and then decomposed to dryness under reduced pressure.The crude product was added with 300 ml of dichloromethane, 15-crown-5 0.1 g,18-crown-6 0.1g, refluxing for 1h,After filtration, the product was dried (162.7 g) (two-step yield 85.1%)

The chemical industry reduces the impact on the environment during synthesis 5343-92-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shanghai Kangpeng Technology Co., Ltd.; Quzhou Kangpeng Chemical Co., Ltd.; He Li; Li Xiaoliang; Tian Zhong; Yang Jianhua; (12 pag.)CN108409708; (2018); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5343-92-0, name is 1,2-Pentanediol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Under an argon protective gas, first 0.644g (2mmol) example XIV-1-1 compound was added to 30 ml of xylene, at room temperature by adding 2.083g (20mmol) 1,2-pentanediol and 0.059g (0.29mmol) p-toluenesulfonic acid, adding 0.5g 4 Molecular sieve (powder) and reflux the mixture for three days of stirring under monitoring by thin layer chromatography. After the reaction, the solvent is distilled away. The product is purified by silica gel column chromatography (dichloromethane/acetone = 5:1). Yield: 0.27g( The theoretical yield 35%), melting point: 273 C.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5343-92-0, 1,2-Pentanediol.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; Bretschneider, Thomas; Fischer, Reiner; Gaertzen, Oliver; Lehr, Stefan; Drewes, Mark Wilhelm; Feucht, Dieter; Malsam, Olga; Reckmann, Udo; Arnold, Christian; Auler, Thomas; Hempel, Waltraud; Hills, Martin Jeffrey; Kehne, Heinz; Rosinger, Christopher Hugh; Sanwald, Erich; (149 pag.)CN101160049; (2016); B;,
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Synthetic Route of 5343-92-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5343-92-0, name is 1,2-Pentanediol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a 1000 mL reaction flask, add 67 g of 1,2-pentanediol, 600 mL of toluene, 149 g of triethylamine, 40 g of calcium oxide, and 4.3 g of tetra-n-butylammonium hydrogen sulfate. Maintain the internal temperature at 0 to 5C, and slowly add the mixture under stirring. Sulfuryl fluoride gas 72g was reacted for 2 hours, nitrogen gas was blown for 1 hour, filtered, and the filtrate was desolvated under reduced pressure to obtain a solid crude product. Toluene 200 mL, 15-crown-5 0.05 g, 18-crown-60.05 g was heated and refluxed to dissolve. Slowly to room temperature, filtration, drying product 77g, yield 71.9%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5343-92-0, 1,2-Pentanediol.

Reference:
Patent; Shanghai Kangpeng Technology Co., Ltd.; Quzhou Kangpeng Chemical Co., Ltd.; Li Xiaoliang; He Li; Tian Zhong; Xiao Hang; (11 pag.)CN107629032; (2018); A;,
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Electric Literature of 5343-92-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5343-92-0, name is 1,2-Pentanediol. This compound has unique chemical properties. The synthetic route is as follows.

IFO therefore was electrochemically oxidized in acetonitrile in the presence of various alcohols with 5 carbon atoms. The reaction was stopped when all the starting material appeared to be consumed as monitored by TLC. At the end of the reaction, sodium bicarbonate (1 Eq.) was added to the medium to neutralize electrogenerated hydrons. The proportions of the various diastereomers were determined on the crude reaction mixture by 31P-NMR before being isolated by ?flash chromatography?.

According to the analysis of related databases, 5343-92-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; INSTITUT GUSTAVE ROUSSY; Paci, Angelo; Martens, Thierry; Rivard, Michael; Couvreur, Patrick; Desmael, Didier; Caron, Joachim; US2013/261088; (2013); A1;,
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