Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 28229-69-8, name is 3-Bromophenethyl alcohol. A new synthetic method of this compound is introduced below., Formula: C8H9BrO
Intermediate 56; 3-(2-Hydroxy-ethyl)-benzoic acid methyl ester; 2-(3-Bromo-phenyl)-ethanol (5.00 g, 24.87 mmol), 1 ,1′-bis(diphenylphosphino) ferrocene-palladium dichloride (0.70 g, 0.85 mmol) and triethylamine (7.00 g, 69.18 mmol) in MeOH (30 ml.) was heated at 90 0C (internal temperature) over a period of 10 h under carbon monoxide atmosphere (5 bar). After cooling to RT the solution was concentrated in vacuo and then partitioned between ethyl acetate and water. The organic layer was washed with brine and evaporated in vacuo. The crude product was purified by flash silica chromatography eluting with ethyl acetate//-hexane (1 :1).Yield: 3.3 g (74%).1H NMR (400 MHz, CDCI3): delta 7.93 – 7.90 (m, 2H), 7.44 (d, J = 7.2 Hz, 1 H),7.39 (t, J = 8.1 Hz, 1 H), 3.92 (s, 3H), 3.89 (t, J = 6.2 Hz, 2H), 2.93 (t, J = 6.4
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Reference:
Patent; ARGENTA DISCOVERY LIMITED; ASTRAZENECA AB; WO2008/149110; (2008); A1;,
Alcohol – Wikipedia,
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