Synthetic Route of 7515-29-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7515-29-9, name is 1-Cyclobutylethanol. This compound has unique chemical properties. The synthetic route is as follows.
In a 20 mL reaction vial, 3-(4-bromo-phenyl)-5-methyl-3H-[l,2,3]triazole-4-carboxylic acid (300 mg, 1.06 mmol), 1-cyclobutylethanol (170 mg, 1.70 mmol) and triethylamine (218 mg, 0.3 mL, 2.15 mmol) were combined with toluene (10 mL) to give a yellow solution and to this was added diphenylphosphorylazide (585 mg, 0.458 mL, 2.13 mmol). The vial’s atmosphere was purged with nitrogen, sealed, heated in an oil bath at 65 C for 2.5 h, and cooled to room temperature overnight. The reaction was diluted with EtOAc and washed with water, saturated ammonium chloride, and brine. The aqueous layers were extracted once with EtOAc. The organic layers were combined, dried over MgS04, filtered, concentrated, diluted with DCM, and purified by flash chromatography (silica gel, 0% to 50% EtOAc in hexanes). Appropriate fractions combined, concentrated, and dried from DCM / hexanes yielding [3-(4-Bromo-phenyl)-5-methyl-3H-[l,2,3]triazol-4-yl]-carbamic acid 1-cyclopropyl-ethyl ester (295.2 mg, 73.2%> yield) as a colorless waxy solid. LC/MS calcd. for Ci6Hi9BrN402 (m/e) 378/380, obsd. 379/381 (M+H, ES+).
According to the analysis of related databases, 7515-29-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GABRIEL, Stephen Deems; HAMILTON, Matthew Michael; QIAN, Yimin; SIDDURI, Achyutharao; WO2013/189865; (2013); A1;,
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