Category: 2503-56-2

Analyzing the synthesis route of 2503-56-2

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2503-56-2, name is 7-Hydroxy-5-methyl-1,3,4-triazaindolizine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H6N4O

The proper 5- Methyl-[1,2,4] triazolo [1,5-a] Pyrimidin-7-ol (10 mmol) was added to 2.75 ml (30 mmol) of phosphorous oxychloride and heated under reflux for 90 min in a round bottom flask. Excess phosphorous oxychloride was removed by distillation at reduced pressure on a steam bath, and the residue was triturated with ice water. The product was extracted from the aqueous mixture with CH2Cl2, evaporated, and purified by column chromatography using 60% EtOAc/hexane. Yield of the product is 55%. 4.1.4.1. 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine (8). White-yellow solid (Rf = 0.6 in pure ethyl acetate); m.p. 150 C.; 1H NMR (300 MHz, CDCl3): delta 8.50 (s, 1H, Triazolopyrimidine-Hb), 7.15 (s, 1H, Triazolopyrimidine-Ha), 2.75 (s, 3H, Triazolopyrimidine-CH3)LCMS: (ESI, m/z): [M+H]+ calcd for C5H6ClN4 169.1; found: 169.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine.

Reference:
Article; Kumar, Jitendra; Meena, Poonam; Singh, Anju; Jameel, Ehtesham; Maqbool, Mudasir; Mobashir, Mohammad; Shandilya, Ashutosh; Tiwari, Manisha; Hoda, Nasimul; Jayaram; European Journal of Medicinal Chemistry; vol. 119; (2016); p. 260 – 277;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Share a compound : 7-Hydroxy-5-methyl-1,3,4-triazaindolizine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H6N4O, blongs to alcohols-buliding-blocks compound. Computed Properties of C6H6N4O

The formed 5-Methyl-[1,2,4] triazolo [1,5-a]Pyrimidin-7-ol (1.0 equiv) was added to 2.75 mL (3.0 equiv) of phosphorous oxychloride and heated under reflux for 90 min in a round bottom flask. Excess phosphorous oxychloride was removed under reduced pressure on a rotatory evaporator, and the residue was triturated with ice water. The product was extracted from the aqueous mixture with CH2Cl2, organic layer was dried over sodium sulphate, evaporated at reduced pressure, and purified by column chromatography using 60% EtOAc/hexane. 4.2.2.1. 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine (7). White-yellow solid; Yield: 55%; mp: 150 C; ESI-MS: m/z 169.1[M+H]+; 1H NMR (300 MHz, CDCl3): delta 8.50 (s, 1H, Triazolopyrimidine-Hb), 7.15 (s, 1H, Triazolopyrimidine-Ha), 2.75 (s, 3H, Triazolopyrimidine-CH3).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine, and friends who are interested can also refer to it.

Reference:
Article; Jameel, Ehtesham; Meena, Poonam; Maqbool, Mudasir; Kumar, Jitendra; Ahmed, Waqar; Mumtazuddin, Syed; Tiwari, Manisha; Hoda, Nasimul; Jayaram; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 36 – 51;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analyzing the synthesis route of 7-Hydroxy-5-methyl-1,3,4-triazaindolizine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine, other downstream synthetic routes, hurry up and to see.

Application of 2503-56-2 ,Some common heterocyclic compound, 2503-56-2, molecular formula is C6H6N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[0171] Compounds 4c. 5-Methyl-pyrazolo[l,5-alpha]pyrimidin-7-ol/7-Methyl-imidazo[l,2- alpha]pyrimidin-5-ol/5-Methyl-[l,2,4]triazolo[l,5-alpha]-pyrimidin-7-ol (3c) (6.5 mmol) was added to 1.82 ml (19.5 mmol) of phosphorus oxychloride and heated under reflux for 30-60 minutes, in a round bottom flask, during which time the solid dissolved and hydrogen chloride was evolved. Excess phosphorus oxychloride was removed by distillation at reduced pressure on a steam-bath and the residue triturated with ice water. Product was extracted from the aqueous mixture with methylene chloride, evaporated and purified by column chromatography using 60% EtOAc/Hexane at a yield of 42-70%.[0172] 7-Chloro-5-methyl-[l,2,4]triazolo[l,5-alpha]pyrimidine (4c). mp. 150 0C. 1H NMR (300 MHz, CDCl3): delta 8.50 (s, IH), 7.15 (s, IH), 2.75 (s, 3H). MS mlz 169.1 (M + H+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM; UNIVERSITY OF WASHINGTON; WO2009/82691; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analyzing the synthesis route of 7-Hydroxy-5-methyl-1,3,4-triazaindolizine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine, other downstream synthetic routes, hurry up and to see.

Application of 2503-56-2 ,Some common heterocyclic compound, 2503-56-2, molecular formula is C6H6N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[0171] Compounds 4c. 5-Methyl-pyrazolo[l,5-alpha]pyrimidin-7-ol/7-Methyl-imidazo[l,2- alpha]pyrimidin-5-ol/5-Methyl-[l,2,4]triazolo[l,5-alpha]-pyrimidin-7-ol (3c) (6.5 mmol) was added to 1.82 ml (19.5 mmol) of phosphorus oxychloride and heated under reflux for 30-60 minutes, in a round bottom flask, during which time the solid dissolved and hydrogen chloride was evolved. Excess phosphorus oxychloride was removed by distillation at reduced pressure on a steam-bath and the residue triturated with ice water. Product was extracted from the aqueous mixture with methylene chloride, evaporated and purified by column chromatography using 60% EtOAc/Hexane at a yield of 42-70%.[0172] 7-Chloro-5-methyl-[l,2,4]triazolo[l,5-alpha]pyrimidine (4c). mp. 150 0C. 1H NMR (300 MHz, CDCl3): delta 8.50 (s, IH), 7.15 (s, IH), 2.75 (s, 3H). MS mlz 169.1 (M + H+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM; UNIVERSITY OF WASHINGTON; WO2009/82691; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts