Analyzing the synthesis route of 7-Hydroxy-5-methyl-1,3,4-triazaindolizine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine, other downstream synthetic routes, hurry up and to see.

Application of 2503-56-2 ,Some common heterocyclic compound, 2503-56-2, molecular formula is C6H6N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

[0171] Compounds 4c. 5-Methyl-pyrazolo[l,5-alpha]pyrimidin-7-ol/7-Methyl-imidazo[l,2- alpha]pyrimidin-5-ol/5-Methyl-[l,2,4]triazolo[l,5-alpha]-pyrimidin-7-ol (3c) (6.5 mmol) was added to 1.82 ml (19.5 mmol) of phosphorus oxychloride and heated under reflux for 30-60 minutes, in a round bottom flask, during which time the solid dissolved and hydrogen chloride was evolved. Excess phosphorus oxychloride was removed by distillation at reduced pressure on a steam-bath and the residue triturated with ice water. Product was extracted from the aqueous mixture with methylene chloride, evaporated and purified by column chromatography using 60% EtOAc/Hexane at a yield of 42-70%.[0172] 7-Chloro-5-methyl-[l,2,4]triazolo[l,5-alpha]pyrimidine (4c). mp. 150 0C. 1H NMR (300 MHz, CDCl3): delta 8.50 (s, IH), 7.15 (s, IH), 2.75 (s, 3H). MS mlz 169.1 (M + H+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2503-56-2, 7-Hydroxy-5-methyl-1,3,4-triazaindolizine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM; UNIVERSITY OF WASHINGTON; WO2009/82691; (2009); A1;,
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Alcohols – Chemistry LibreTexts