Category: 4654-39-1

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4654-39-1, name is 2-(4-Bromophenyl)ethanol. A new synthetic method of this compound is introduced below., SDS of cas: 4654-39-1

To a mixture of 2-(4- bromophenyl)ethanol (10.0 g, 49.7 mmol) in DCM (100 mL) were added imidazole (10.0 g, 149.2 mmol) and TBSC1 (8.2 g, 54.7 mmol) at 0 C. After stirring at room temperature for 3 h, the reaction mixture was quenched with water, extracted with DCM. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated. The crude was purified by silica gel column (PE: EA = 50: 1) to get (4-bromophenethoxy)(tert-butyl)dimethylsilane (16.2 g, 99%) as a colorless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4654-39-1, 2-(4-Bromophenyl)ethanol.

Reference:
Patent; NIKANG THERAPEUTICS, INC.; LOU, Yan; FU, Jiping; HE, Yigang; (0 pag.)WO2020/14332; (2020); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, molecular weight is 201.06, as common compound, the synthetic route is as follows.Computed Properties of C8H9BrO

The reaction kettle was charged with 4-bromophenethyl alcohol (1.0 kg, 5.0 mol) 10 times the volume of methylene chloride dissolved, Triethylamine (1.01 kg, 10.0 mol) And catalytic amount of DMAP, TBSCl (0.9 kg, 6.0 mol) was added in batches. Reaction to the disappearance of raw materials at room temperature, Washed, Saturated brine, After drying with anhydrous sodium sulfate, the liquid compound VA (1.5 kg, 95.5%) was obtained as a colorless oil. Directly into the next reaction.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4654-39-1, 2-(4-Bromophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Hangzhou Lide Biological Technology Co., Ltd.; Ren Guobao; Wu Yan; Li Chuanbin; (6 pag.)CN106565467; (2017); A;,
Alcohol – Wikipedia,
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Reference of 4654-39-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Reference Example 2 2-(4-bromophenyl)ethyl iodide To a solution of 2-(4-bromophenyl)ethanol(75.0 g) and triethylamine (45.3 g) in methylene chloride (400 mL) was added dropwise methanesulfonyl chloride (47.0 g) at 0C over 1 hr, and the mixture was stirred at the same temperature for 3 hr. The reaction mixture was poured into ice water, and the organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. To a solution of the residue in methyl ethyl ketone (500 mL) was added sodium iodide (67.1 g), and the mixture was stirred at 90C for 3 hr. The reaction mixture was concentrated under reduced pressure, and water (500 mL) was added to the residue. After extraction with ethyl acetate, the mixture was washed with 1% aqueous sodium thiosulfate solution and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (116 g) as brown crystals. 1H-NMR(CDCl3)delta(ppm): 3.13(2H, t, J=7.7Hz), 3.32(2H, d, J=7.4Hz), 7.07(2H, d, J=8.4Hz), 7.44(2H, d, J=8.1Hz).

According to the analysis of related databases, 4654-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2017257; (2009); A1;,
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Synthetic Route of 4654-39-1 ,Some common heterocyclic compound, 4654-39-1, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Dissolve 31.6 g of iodine, 33.9 g of triphenylphosphine and 22.4 mg of imidazole in anhydrous dichloromethane (100 mL), After cooling in an ice bath for 30 minutes, 20.0 g of p-bromobenzyl alcohol was dissolved in anhydrous dichloromethane (50 mL) and quickly added dropwise to the reaction bottle.Remove the ice bath and react at room temperature for about 6 hours.Distill off the methylene chloride, add a water-methanol mixture solution (400mL, water: methanol volume ratio of 1:3), transfer to a separatory funnel, add n-heptane extraction (200mL×3), shake vigorously until the whole system is free The color is transparent and the organic layers are combined.It was dried over anhydrous sodium sulfate, and the organic solvent was distilled off to obtain a colorless transparent solid, that is, compound 11. The product was stored in the dark and the yield was 93.2%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4654-39-1, 2-(4-Bromophenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Zeyu; Chen Si; Xiao Qiong; Zhang Xiang; Tian Yulin; Yin Dali; (11 pag.)CN111087358; (2020); A;,
Alcohol – Wikipedia,
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Reference of 4654-39-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, molecular weight is 201.06, as common compound, the synthetic route is as follows.

1.31.a. 2-[2-(4-bromo-phenyl)-ethoxy]-tetrahydro-pyran 0.025 g of p-toluenesulphonic acid and 2.575 ml (28.22 mmol) of dihydropyran are added successively to a solution of 4.83 g (24.02 mmol) of 2-(4-bromo-phenyl)-ethanol in 12 ml dichloromethane at 0 C. Then the reaction mixture is stirred for three hours at ambient temperature. The reaction mixture is extracted with sodium hydrogen carbonate solution and the organic phase is dried over sodium sulphate. The purification is carried out by column chromatography on Alox (eluant: cyclohexane/ethyl acetate=8:2). Yield: 37 g (32.8% of theory); C13H17BrO2 (M=285.18); calc.: molar peak (M)+: 284/286 fnd.: molar peak (M)+: 284/286.

Statistics shows that 4654-39-1 is playing an increasingly important role. we look forward to future research findings about 2-(4-Bromophenyl)ethanol.

Reference:
Patent; Boehringer Ingelheim International GmbH; US2004/242572; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 4654-39-1, 2-(4-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4654-39-1, blongs to alcohols-buliding-blocks compound. SDS of cas: 4654-39-1

Example 1.60: Preparation of Intermediate 4-Bromophenethyl Methanesulfonate. 4-Bromophenethyl alcohol (38.9 g, 193 mmol) was dissolved in DCM (193 mL).Triethylamine (40.4 mL, 290 mmol) was added and the mixture was cooled in an ice bath. Methanesulfonyl chloride (18 mL, 232 mmol) was added dropwise via an addition funnel. The ice bath was removed and the mixture was stirred for 30 min. The reaction mixture was diluted with DCM (200 mL), washed with 1 M HCl twice (100 mL each), followed by brine, saturated sodium bicarbonate, and brine. The organic phase was dried with sodium sulfate and filtered. The solvent was removed under reduced pressure to give the title compound (54.0 g) in quantitative yield. 1H NMR (400 MHz, CDCl3) delta ppm 2.89 (s, 3 H), 3.02 (t, J = 6.82 Hz, 2 H), 4.40 (t, J= 6.82 Hz, 2 H), 7.03 – 7.17 (m, 2 H), 7.43 – 7.47 (m, 2 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4654-39-1, its application will become more common.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2009/105206; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 4654-39-1, 2-(4-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4654-39-1, blongs to alcohols-buliding-blocks compound. Quality Control of 2-(4-Bromophenyl)ethanol

Example 1.60: Preparation of Intermediate 4-Bromophenethyl Methanesulfonate. 4-Bromophenethyl alcohol (38.9 g, 193 mmol) was dissolved in DCM (193 mL).Triethylamine (40.4 mL, 290 mmol) was added and the mixture was cooled in an ice bath. Methanesulfonyl chloride (18 mL, 232 mmol) was added dropwise via an addition funnel. The ice bath was removed and the mixture was stirred for 30 min. The reaction mixture was diluted with DCM (200 mL), washed with 1 M HCl twice (100 mL each), followed by brine, saturated sodium bicarbonate, and brine. The organic phase was dried with sodium sulfate and filtered. The solvent was removed under reduced pressure to give the title compound (54.0 g) in quantitative yield. 1H NMR (400 MHz, CDCl3) delta ppm 2.89 (s, 3 H), 3.02 (t, J = 6.82 Hz, 2 H), 4.40 (t, J= 6.82 Hz, 2 H), 7.03 – 7.17 (m, 2 H), 7.43 – 7.47 (m, 2 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4654-39-1, its application will become more common.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2009/105206; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C8H9BrO

A mixture of 2-(4-bromophenyl)ethan-1-ol (60 g, 300 mmol), BISPIN (84 g, 330 mmol), KOAc (90 g, 900 mmol) and PdC (dppf) (6.6 g, 9 mmol) in 1 ,4-dioxane (600 ml) was stirred under N2at 85C for 16 h. The RM was cooled to RT, filtered, the filtrate was concentrated and the residue purified by chromatography on silica gel eluting with EtOAc in petroleum ether (from 0 to 30%) to afford of the title compound as an oil (100 g).Method J: Rt = 1.87 min, [M+NH4]+= 266.

With the rapid development of chemical substances, we look forward to future research findings about 4654-39-1.

Reference:
Patent; NOVARTIS AG; ARISTA, Luca; HEBACH, Christina; HOLLINGWORTH, Gregory John; HOLZER, Philipp; IMBACH-WEESE, Patricia; LORBER, Julien; MACHAUER, Rainer; SCHMIEDEBERG, Niko; VULPETTI, Anna; ZOLLER, Thomas; (178 pag.)WO2019/186343; (2019); A1;,
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Reference of 4654-39-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4654-39-1 as follows.

1 -Bromo-4-(2-iodoethyl)benzeneA solution of 2-(4-bromophenyl)ethanol (40.0 g, 0.199 mol) in dichloromethane (10 mL) was added dropwise to a solution of imidazole (22.4 mg, 0.329 mmol), triphenylphosphine (66.5 g, 0.254 mol), and iodine (65.0 g, 0.26 mol) indichloromethane (50 mL) at 0C. When the addition was complete it was warmed to rt. After 1 hour the reaction was filtered through celite, the filtrate was washed with saturated aqueous sodium thiosufate (2×100 mL), brine (100 mL), dried over MgS04, filtered and concentrated in vacuo. Purification by flash column chromatography on silica gel (heptane/ethyl acetate 4: 1 ) afforded the title compound as a yellow-white solid (59.09 g, 60%). 1 HNMR (400 MHz, CHLOROFORM-d) delta ppm 3.14 (t, J=7.69 Hz, 2 H) 3.33 (t, J=7.69 Hz, 2 H) 7.08 (d, J=7.89 Hz, 2 H) 7.45 (d, J=8.31 Hz, 2 H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4654-39-1, its application will become more common.

Reference:
Patent; PFIZER INC.; BROWN, Matthew Frank; MARFAT, Anthony; MELNICK, Michael Joseph; REILLY, Usa; WO2011/45703; (2011); A2;,
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Alcohols – Chemistry LibreTexts

Electric Literature of 4654-39-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4654-39-1, name is 2-(4-Bromophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Dissolve 31.56g of iodine, 33.91g of triphenylphosphine and 22.35mg of imidazole in anhydrous dichloromethane (100mL), After 30 minutes in an ice bath, 20 g of p-bromobenzyl alcohol was dissolved in anhydrous dichloromethane (50 mL) and quickly added dropwise to the reaction bottle. Remove the ice bath and react at room temperature for about 6 hours. Dichloromethane was distilled off, the reaction liquid was transferred to a separatory funnel, a water-methanol mixed solution (400 mL, water: methanol volume ratio of 1:3) was added, n-heptane extraction (150 mL×3) was added, and shaken vigorously until The whole system is colorless and transparent, and the organic layer is combined. The organic layer was dried over anhydrous sodium sulfate, and the organic solvent was distilled off to obtain a colorless solid, that is, compound 10. The product was stored in the dark and the yield was 93.2%.

According to the analysis of related databases, 4654-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Chen Si; Shi Zeyu; Xiao Qiong; Zhang Xiang; Tian Yulin; Yin Dali; (13 pag.)CN111087356; (2020); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts