Adding a certain compound to certain chemical reactions, such as: 4654-39-1, 2-(4-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4654-39-1, blongs to alcohols-buliding-blocks compound. Quality Control of 2-(4-Bromophenyl)ethanol
Example 1.60: Preparation of Intermediate 4-Bromophenethyl Methanesulfonate. 4-Bromophenethyl alcohol (38.9 g, 193 mmol) was dissolved in DCM (193 mL).Triethylamine (40.4 mL, 290 mmol) was added and the mixture was cooled in an ice bath. Methanesulfonyl chloride (18 mL, 232 mmol) was added dropwise via an addition funnel. The ice bath was removed and the mixture was stirred for 30 min. The reaction mixture was diluted with DCM (200 mL), washed with 1 M HCl twice (100 mL each), followed by brine, saturated sodium bicarbonate, and brine. The organic phase was dried with sodium sulfate and filtered. The solvent was removed under reduced pressure to give the title compound (54.0 g) in quantitative yield. 1H NMR (400 MHz, CDCl3) delta ppm 2.89 (s, 3 H), 3.02 (t, J = 6.82 Hz, 2 H), 4.40 (t, J= 6.82 Hz, 2 H), 7.03 – 7.17 (m, 2 H), 7.43 – 7.47 (m, 2 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4654-39-1, its application will become more common.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; WO2009/105206; (2009); A1;,
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