Category: 134575-13-6

Electric Literature of 134575-13-6, Adding some certain compound to certain chemical reactions, such as: 134575-13-6, name is exo-3-Azabicyclo[3.1.0]hexan-6-ylmethanol,molecular formula is C6H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 134575-13-6.

Step A (1alpha,5alpha,6alpha)-3-(tert-Butoxycarbonyl)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane A solution of di-tert-butyl dicarbonate (967 mg, 4.42 mmol) in CH2Cl2 (3.0 mL) was added to a stirred solution of (1alpha,5alpha,6alpha)-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane (456 mg, 4.02 mmol, for preparation see K. E. Brighty and M. J. Castaldi, Synlett, 1996, 1097-1099) in CH2Cl2 (7.0 mL) at RT. After 15 h, the solution was partitioned between 2 N aq. HCl (50 mL) and EtOAc (50 mL). The organic layer was washed with saturated aq. NaHCO3 (50 mL) and saturated aq. NaCl (50 mL). The aqueous layers were extracted in succession with EtOAc (2*50 mL). The organic layers were dried (Na2SO4), decanted, and evaporated. The crude product was purified by flash column chromatography on silica gel, eluding with 80:20 v/v to 0:100 hexane/EtOAc to give the title compound as a colorless syrup. For the title compound: 1H NMR (500 MHz, CDCl3) delta 3.60 (d, J=11, 2H), 3.53 (d, J=6, 2H), 3.36 (d, J=11, 2H), 1.44 (s, 11H), 0.96 (tt, J=6, 3, 1H); ESI-MS 158.1 (M+H-56); HPLC A: 2.09 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 134575-13-6, exo-3-Azabicyclo[3.1.0]hexan-6-ylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hale, Jeffrey J.; Lynch, Christopher L.; Caldwell, Charles G.; Willoughby, Christopher A.; Kim, Dooseop; Shen, Dong-Ming; Mills, Sander G.; Chapman, Kevin T.; Chen, Liya; Gentry, Amy; MacCoss, Malcolm; Konteatis, Zenon D.; US2002/94989; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 134575-13-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 134575-13-6, name is exo-3-Azabicyclo[3.1.0]hexan-6-ylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

(1R,5S,6R)-3-Azabicyclo[3.1.0]hexan-6-ylmethanol 31a (10 g, 88.4 mmol) was dissolved in a mixed solvent of dioxane and H2O (V/V=3/2), followed by addition of sodium hydroxide (4.2 g, 106 mmol) and di-tert-butyl dicarbonate (28.9 g, 132.6 mmol). After reacting for 10 hours, 50 mL of H2O was added to the reaction mixture. The reaction mixture was extracted with ethyl acetate (150 mLx3). The organic phases were combined, washed with saturated sodium chloride solution (50 mLx2), dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography with elution system C to obtain the title product (1R,5S,6R)-tert-butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate 31b (16.9 g, yield 89.9%) as a light yellow liquid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 134575-13-6, exo-3-Azabicyclo[3.1.0]hexan-6-ylmethanol.

Reference:
Patent; Zhang, Xuejun; Dong, Qing; Liu, Bonian; Zhu, Yaoping; Li, Xiaotao; Lan, Jiong; US2014/336207; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts