Category: 4541-15-5

Synthetic Route of 4541-15-5, Adding some certain compound to certain chemical reactions, such as: 4541-15-5, name is 5-(Benzyloxy)pentan-1-ol,molecular formula is C12H18O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4541-15-5.

00193] 5-Benzyloxy-pentanoic acid (29)[00194] Jones reagent was added dropwise to an ice cooled solution of 5-benzyloxy-pentan- 1 – ol 28 (5 g, 25.74 mmol) in acetone (170 ml). Addition of the Jones reagent was stopped when the acetone solution acquired a persistent yellow color with the concurrent formation of green chromium salts. The mixture was filtered and concentrated in vacuo to give an oily crude product that was purified by a flash chromatography (EtOAc / hexanes, 1 :3) to give compound 29 (4.98 g, 93%) as a colorless oil: TLC R/= 0.68 (silica gel, 50% EtOAc / hexanes); 1HNMR (400 MHz, CDCl3) delta 7.35-7.31 (m, 5H), 4.502 (s, 2H), 3.51-3.47 (t,3J= 6 Hz, 2H), 2.41-2.36 (t, 3J= 6.8 Hz, 2H), 1.79-1.64 (m, 4H); 13C NMR (75 MHz, CDCl3) 5179.713, 138.651, 128.609, 127.870, 127.795, 73.158, 69.968, 33.915, 29.243, 21.749; HRMS calcd for C12H16O3 + Na+ 231.0997; found 231.0992 [M + Na+].

According to the analysis of related databases, 4541-15-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UNIVERSITY OF TOLEDO; WO2007/15929; (2007); A2;,
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Synthetic Route of 4541-15-5, Adding some certain compound to certain chemical reactions, such as: 4541-15-5, name is 5-(Benzyloxy)pentan-1-ol,molecular formula is C12H18O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4541-15-5.

00193] 5-Benzyloxy-pentanoic acid (29)[00194] Jones reagent was added dropwise to an ice cooled solution of 5-benzyloxy-pentan- 1 – ol 28 (5 g, 25.74 mmol) in acetone (170 ml). Addition of the Jones reagent was stopped when the acetone solution acquired a persistent yellow color with the concurrent formation of green chromium salts. The mixture was filtered and concentrated in vacuo to give an oily crude product that was purified by a flash chromatography (EtOAc / hexanes, 1 :3) to give compound 29 (4.98 g, 93%) as a colorless oil: TLC R/= 0.68 (silica gel, 50% EtOAc / hexanes); 1HNMR (400 MHz, CDCl3) delta 7.35-7.31 (m, 5H), 4.502 (s, 2H), 3.51-3.47 (t,3J= 6 Hz, 2H), 2.41-2.36 (t, 3J= 6.8 Hz, 2H), 1.79-1.64 (m, 4H); 13C NMR (75 MHz, CDCl3) 5179.713, 138.651, 128.609, 127.870, 127.795, 73.158, 69.968, 33.915, 29.243, 21.749; HRMS calcd for C12H16O3 + Na+ 231.0997; found 231.0992 [M + Na+].

According to the analysis of related databases, 4541-15-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UNIVERSITY OF TOLEDO; WO2007/15929; (2007); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4541-15-5, name is 5-(Benzyloxy)pentan-1-ol, molecular formula is C12H18O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 4541-15-5

To a stirred solution of benzylated alcohol 10 (5.0 g, 25.77 mmol) in CH2Cl2 (80 mL) at rt was added TEMPO (40 mg, 2.57 mmol) and reaction the mixture was stirred for 10 min, followed by the addition of iodobis(acetoxy)benzene (9.13g, 28.35 mmol). The mixture was stirred for additional 1 h and then diluted with CH2Cl2 (20 mL). The mixture was then washed with sat. aq Na2S2O3 (15 mL) and extracted with CH2Cl2 (3 x 10 mL). The combined organic extracts were dried (Na2SO4) and concentrated in vacuo followed by purification with silica gel column chromatography using pet ether: ethylacetate (20:1) as eluent that afforded pure aldehyde 11. Yield: 95% (4.70 g), colorless oil; IR (CHCl3, cm-1): upsilonmax 696, 753, 1039, 1098, 1106, 1242, 1275, 1454, 1710, 2941; 1H NMR (200 MHz, CDCl3): delta 1.51-1.85(m, 5H), 2.34-2.61 (m, 2H), 3.47 (t, J = 5.9 Hz, 2H), 4.48 (s, 2H),7.26-7.43 (m, 5H), 9.75 (t, J = 1.6 Hz, 1H); 13C NMR (50 MHz, CDCl3): delta 18.9, 29.0, 43.4, 69.6, 72.8, 127.5, 128.2, 130.1, 138.3, 201.8; HRMS (ESI): calc.for [(C12H16O2)H](M+H) 193.1229, found 193.1223.

With the rapid development of chemical substances, we look forward to future research findings about 4541-15-5.

Reference:
Article; Gadakh, Sunita K.; Sudalai, Arumugam; Tetrahedron Letters; vol. 57; 1; (2016); p. 25 – 28;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4541-15-5, name is 5-(Benzyloxy)pentan-1-ol, molecular formula is C12H18O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 5-(Benzyloxy)pentan-1-ol

Et3N (10.79 mL, 78 mmol) was added in one portion via syringe to a solution of 5-Benzyloxy-1- pentanol (10.08 g, 51.9 mmol) in DCM (75 mL) in a round bottom flask charged with a magnetic stir bar at 0 C under N2. Next, MsCI (4.85 ml_, 62.3 mmol) was added dropwise via syringe in 4 separate portions at a rate such that the internal temperature did not exceed 15 C. The reaction was allowed to continue to stir for 1 hour, after which it was diluted with H20 (200 ml_) and DCM (150 ml_). The organic layer was separated, and the aqueous layer was washed with DCM (225 ml_). The combined organic layers were washed with brine (200 ml_), dried with Na2S04, filtered, and concentrated under reduced pressure to provide the title compound as a crude orange oil (14.46 g). MS (M + 1 ) = 272.9, Rt = 1.33 min (LC method 13).

With the rapid development of chemical substances, we look forward to future research findings about 4541-15-5.

Reference:
Patent; NOVARTIS AG; BRITO, Luis; CHEN, Delai; GAMBER, Gabriel Grant; GEALL, Andrew; LOVE, Kevin; ZABAWA, Thomas; ZECRI, Frederic; WO2015/95340; (2015); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4541-15-5, name is 5-(Benzyloxy)pentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. name: 5-(Benzyloxy)pentan-1-ol

To a solution of triphenylphosphine (6.8 g, 25.7 mmol) in dichloromethane (100 mL) at 0 C was added bromine (1.3 mL, 25.7 mmol) and the mixture stirred for 30 minutes. A solution of the alcohol 33 (5.0 g, 25.7 mmol) in dichloromethane (20 mL) and pyridine (2.1 mL, 25.7 mmol) were added and the mixture was warmed to room temperature and stirred for 4 hours. The volatiles were removed and the residue suspended in water (200 mL), extracted with diethyl ether (3 x 100 mL) and dried over anhydrous magnesium sulfate. The ethereal extracts were concentrated (to ~100 mL) and hexane (100 mL) was added. The resulting precipitate was removed by filtration and the filtrate was aged at -30 C for 24 hours. The large crystals of triphenylphosphine oxide were removed by filtration and the filtrate concentrated to obtain the title compound 34 (5.8 g, 88%) as a colourless oil, the spectroscopic data of which corresponded to previously described. Rf: 0.34 (1:19 ethyl acetate, hexane).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4541-15-5, 5-(Benzyloxy)pentan-1-ol.

Reference:
Article; Moir, Michael; Lane, Samuel; Lai, Felcia; Connor, Mark; Hibbs, David E.; Kassiou, Michael; European Journal of Medicinal Chemistry; vol. 180; (2019); p. 291 – 309;,
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4541-15-5 ,Some common heterocyclic compound, 4541-15-5, molecular formula is C12H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation of Intermediate 1a: 5-(benzyloxy)pentyl methanesulfonate. [0387] Et3N (10.79 mL, 78 mmol) was added in one portion by syringe to a solution of 5-Benzyloxy-1 -pentanol (10.08 g, 51 .9 mmol) in DCM (75 mL) in a round bottom flask charged with a magnetic stir bar at 0C under N2. Next, MsCI (4.85 mL, 62.3 mmol) was added dropwise by syringe in 4 separate portions at a rate such that the internal temperature did not exceed 15C. The reaction was allowed to continue to stir for 1 hour, after which it was diluted with H20 (200 mL) and DCM (150 mL). The organic layer was separated, and the aqueous layer was washed with DCM (225 mL). The combined organic layers were washed with brine (200 mL), dried with Na2S04, filtered, and concentrated under reduced pressure to provide the title compound as a crude orange oil (14.46 g, 99%). [0388] Mass spectroscopy (“MS”) (m+1 ) = 272.9.

According to the analysis of related databases, 4541-15-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; BYERS, Crystal; CAPLAN, Shari Lynn; GAMBER, Gabriel Grant; HAHM, Seung; HELDWEIN, Kurt Alex; SPLAWSKI, Igor; ZABAWA, Thomas; ZECRI, Frederic; WO2015/95351; (2015); A1;,
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