4541-15-5 ,Some common heterocyclic compound, 4541-15-5, molecular formula is C12H18O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Preparation of Intermediate 1a: 5-(benzyloxy)pentyl methanesulfonate. [0387] Et3N (10.79 mL, 78 mmol) was added in one portion by syringe to a solution of 5-Benzyloxy-1 -pentanol (10.08 g, 51 .9 mmol) in DCM (75 mL) in a round bottom flask charged with a magnetic stir bar at 0C under N2. Next, MsCI (4.85 mL, 62.3 mmol) was added dropwise by syringe in 4 separate portions at a rate such that the internal temperature did not exceed 15C. The reaction was allowed to continue to stir for 1 hour, after which it was diluted with H20 (200 mL) and DCM (150 mL). The organic layer was separated, and the aqueous layer was washed with DCM (225 mL). The combined organic layers were washed with brine (200 mL), dried with Na2S04, filtered, and concentrated under reduced pressure to provide the title compound as a crude orange oil (14.46 g, 99%). [0388] Mass spectroscopy (“MS”) (m+1 ) = 272.9.
According to the analysis of related databases, 4541-15-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; BYERS, Crystal; CAPLAN, Shari Lynn; GAMBER, Gabriel Grant; HAHM, Seung; HELDWEIN, Kurt Alex; SPLAWSKI, Igor; ZABAWA, Thomas; ZECRI, Frederic; WO2015/95351; (2015); A1;,
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