Category: 1082066-29-2

Application of 1082066-29-2On October 31, 2019 ,《Arylboronate prodrugs of doxorubicin as promising chemotherapy for pancreatic cancer》 appeared in Bioorganic Chemistry. The author of the article were Skarbek, Charles; Serra, Silvia; Maslah, Hichem; Rascol, Estelle; Labruere, Raphael. The article conveys some information:

This study describes the synthesis of arylboronate-based ROS-responsive prodrugs of doxorubicin and their biol. evaluation as anticancer agents. The determination of the most sensitive cancer type toward arylboronate prodrugs is crucial for further consideration of these mols. in clin. phase. To address this goal, an arylboronate-based profluorescent probe was used to compare the capacity of various cancer cell lines to efficiently convert the precursor into the free fluorophore. On the selected MiaPaCa-2 pancreatic cancer cells, a benzeneboronate prodrug exhibited 67% of the cytotoxicity obtained with the free doxorubicin. The prodrug was also able to induce tumor regression on MiaPaCa-2 pancreatic tumor model in ovo. Using this model, the amount of free doxorubicin liberated from this prodrug into the tumor was equivalent to the quantity measured after direct intratumoral injection of the same concentration of doxorubicin. After reading the article, we found that the author used (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2Application of 1082066-29-2)

(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Application of 1082066-29-2

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formula: C13H18BFO3On October 1, 2019 ,《Bis(het)aryl-1,2,3-triazole quinuclidines as α7 nicotinic acetylcholine receptor ligands: Synthesis, structure affinity relationships, agonism activity, [18F]-radiolabeling and PET study in rats》 was published in European Journal of Medicinal Chemistry. The article was written by Ouach, Aziz; Vercouillie, Johnny; Bertrand, Emilie; Rodrigues, Nuno; Pin, Frederic; Serriere, Sophie; Boiaryna, Liliana; Chartier, Agnes; Percina, Nathalie; Tangpong, Pakorn; Gulhan, Zuhal; Mothes, Celine; Deloye, Jean-Bernard; Guilloteau, Denis; Page, Guylene; Suzenet, Franck; Buron, Frederic; Chalon, Sylvie; Routier, Sylvain. The article contains the following contents:

In this paper we describe the design and synthesis of bis(Het)Aryl-1,2,3-triazole quinuclidine α7R ligands using an efficient three-step sequence including a Suzuki-Miyaura cross coupling reaction with com. available and home-made boron derivatives The exploration of SAR required the preparation of uncommon boron derivatives Forty final drugs were tested for their ability to bind the target and nine of them exhibited Ki values below nanomolar concentrations The best scores were always obtained when the 5-phenyl-2-thiophenyl core was attached to the triazole. The selectivity of these compounds towards the nicotinic α4β2 and serotoninergic 5HT3 receptors was assessed and their brain penetration was quantified by the preparation and in vivo evaluation of two [18F] radiolabeled derivatives It can be expected from our results that some of these compounds will be suitable for further developments and will have effects on cognitive disorders. The results came from multiple reactions, including the reaction of (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2Formula: C13H18BFO3)

(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Formula: C13H18BFO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

SDS of cas: 1082066-29-2On October 2, 2019 ,《Para-Selective, Iridium-Catalyzed C-H Borylations of Sulfated Phenols, Benzyl Alcohols, and Anilines Directed by Ion-Pair Electrostatic Interactions》 was published in Journal of the American Chemical Society. The article was written by Montero Bastidas, Jose R.; Oleskey, Thomas J.; Miller, Susanne L.; Smith, Milton R.; Maleczka, Robert E.. The article contains the following contents:

Para C-H borylations (CHB) of tetraalkylammonium sulfates [R4N][ArOSO3] (R = n-Pr, Bu) and sulfamates [Bu4N][ArNHSO3] have been achieved using bipyridine-ligated Ir boryl catalysts, 4,4′-R2bpy/[Ir(cod)(OMe)]2/B2pin2, yielding borylated phenols 4-(pinB)-RC6H3OH (R = halo, Me, CN, CF3, CF3O, OMe), together with minor amounts of meta-isomers. Selectivities can be modulated by both the length of the alkyl groups in the tetraalkylammonium cations and the substituents on the bipyridine ligands. Ion pairing, where the alkyl groups of the cation shield the meta C-H bonds in the counteranions, is proposed to account for para selectivity. The 4,4′-dimethoxy-2,2′-bipyridine ligand gave superior selectivities. In the experiment, the researchers used many compounds, for example, (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2SDS of cas: 1082066-29-2)

(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol(cas: 1082066-29-2) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. SDS of cas: 1082066-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts