Category: 73978-41-3

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.73978-41-3, name is (2,4-Diaminopteridin-6-yl)methanol hydrochloride, molecular formula is C7H9ClN6O, molecular weight is 228.639, as common compound, the synthetic route is as follows.Recommanded Product: (2,4-Diaminopteridin-6-yl)methanol hydrochloride

0J 89j 4 FontWeight=”Bold” FontSize=”10″ Araino FontWeight=”Bold” FontSize=”10″ 4-deoxy-l O-A^nethyipterok Acid (APA, 2) ( raovec. I; Spencer, G.; Blair, A. H.; Mammen, M; Singh, M,; Ghose, T. J. Med Chem., 1989, 32, 2426). A mixture of 249 rag (0.59 mraol) dibromotripheaylphosphorane and 45,0 mg (0.20 tnmol) 2,4-diaraino-6-(hydr )xymethyl)pteridin.e hydrochloride (1) in 1 .5 mL of anhydrous dmieihylacetamide was stirred at room iemperatare for 24 h under an argon atmosphere. To the reaction mixture were added 41 mg (0.27 mmol) of 4-(methylamino)benzoic acid and 0,16 mL { 116 mg, 0,90 mmol) of DIPEA and the reaction mixture was stirred at room temperature for 48 h, and then at 60 ‘”‘C for 24 fi. The cooled reaction mixture was poured into 25 mL of 0.33 M aq NaOH and the precipitate was filtered. The filtrate was adjusted to H 5.5 with 10% acetic acid and the resulting precipitate was collected through filtration, washed wi h water and dried under diminished pressure at 80 C overnight to obtain 2 as an orange solid: yield 42 mg (56%); silica gel TLC – 0.47 (5:4: 1 chlorofornv-methanol-water); lH NM (DMSO-<&) o 3.19 (s, 3H), 4.76 (s, 2H), 6.61 (s, 2H>, 6.78 (d, 21i J- 8.9 Hz), 7.72 (d, 2H, J- 8.7 Hz) and 8.56 (s, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,73978-41-3, (2,4-Diaminopteridin-6-yl)methanol hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; ARIZONA BOARD OF REGENTS, FOR AND ON BEHALF OF, ARIZONA STATE UNIVERSITY; HECHT, Sidney; PAUL, Rakesh; TANG, Chenhong; MADATHIL, Manikandadas; BHATTACHARYA, Chandraball; WO2014/145109; (2014); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 73978-41-3, name is (2,4-Diaminopteridin-6-yl)methanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 73978-41-3

2,4-diamino-6-(hydroxymethyl)pteridine hydrochloride (4.40 g; 19.19 mmol) was dissolved in hot water (150 mL) and the solution was neutralized by addition of 1 M NaOH (ca. 20 mL). The precipitate was filtered, washed with water, and dried in vacuo over P2O5. Subsequently, this was suspended in DMAc (25 mL), and triphenylphosphine dibromide (18.12 g; 42.92 mmol) was added. The turbid reaction mixture was stirred for 20 hr at 200C. 4-(Methylamino)benzoic acid (2.95 g; 19.50 mmol) and DIPEA (5.04 g; 39.00 mmol) were added, and the turbid reaction mixture was stirred for 3 days at 200C. Then, it was poured in 0.33 M NaOH-solution (250 mL), the precipitate was filtered off, and the filtrate was neutralized by addition of 10% acetic acid in water (ca. 20 mL). The precipitate was filtered, washed with water, triturated with methanol (30 mL), and dried in vacuo over P2O5, to yield the product as a beige/orange powder (3.48 g; 56%).1H-NMR (DMSO): delta 8.59 (s, IH), 7.53 (d, 2H, 8.8 Hz), 7.7 (br. s, IH), 7.5 (br. s, IH), 6.83 (d, 2H, 8.8 Hz), 4.79 (s, 2H), 3.23 (s, 3H) ppm. FT-IR (ATR): V 3335, 3194, 2964, 1651, 1597, 1292, 1187 cm”1.

With the rapid development of chemical substances, we look forward to future research findings about 73978-41-3.

Reference:
Patent; KONINKLIJKE PHILIPS ELECTRONICS N.V.; WO2007/110811; (2007); A2;,
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Related Products of 73978-41-3 ,Some common heterocyclic compound, 73978-41-3, molecular formula is C7H9ClN6O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Initially, the compound 6-bromomethyl-pteridine-2,4-diamine as shown inFormula XIIIH9N N N(XIII)was prepared by first suspending 2,4-diamino-6-(hydroxymethyl)pteridine hydrochloride(2.29 g, 10 mmol) in 100 ml glacial acetic acid, warming to reflux and then allowing tocool to ambient temperature. Hydrobromic acid and 30% AcOH solution (191 ml) wasthen added and the flask stoppered for 4 days. The reaction mixture was then poured into1200 ml dry diethyl ether with stirring. The product was allowed to settle and excesssolvent was removed by decantation. The product was collected, washed with additionalether, and dried for later use.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73978-41-3, its application will become more common.

Reference:
Patent; SERENEX, INC.; WO2006/14706; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts