Category: 55346-97-9

Zhao, Hongyi published the artcileEfficient and stereoselective one-pot synthesis of benzo[b]oxazolo[3,4-d][1,4]oxazin-1-ones, Recommanded Product: 4,5-Difluoro-2-nitrophenol, the publication is RSC Advances (2020), 10(40), 24037-24044, database is CAplus and MEDLINE.

An efficient and mild one-pot convergent synthesis protocol has been developed for benzo[b]oxazolo[3,4-d][1,4]oxazin-1-one derivatives through the Mitsunobu reaction and sequential cyclization. Various tricyclic fused benzoxazinyl-oxazolidinones (20 examples) were obtained in good to excellent yields and high enantioselectivities with facile operation. Furthermore, four stereoisomers were afforded resp. in high ee values (>97.8%) via using different chiral 2,3-epoxy-4-trityloxybutanol. This methodol. has been applied to the synthesis of key intermediates of drug candidates.

RSC Advances published new progress about 55346-97-9. 55346-97-9 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 4,5-Difluoro-2-nitrophenol, and the molecular formula is C24H29N5O3, Recommanded Product: 4,5-Difluoro-2-nitrophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sams, Anette G. published the artcileDiscovery of N-{1-[3-(3-Oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): An Allosteric Muscarinic M₁ Receptor Agonist with Unprecedented Selectivity and Procognitive Potential, Related Products of alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2010), 53(17), 6386-6397, database is CAplus and MEDLINE.

The discovery and structure-activity relationship (SAR) of a series of allosteric muscarinic M₁ receptor agonists are described. Compound 17 (Lu AE51090) was identified as a representative compound from the series, based on its high selectivity as an agonist at the muscarinic M₁ receptor across a panel of muscarinic receptor subtypes. Furthermore, 17 displayed a high degree of selectivity when tested in a broad panel of G-protein-coupled receptors, ion channels, transporters, and enzymes, and 17 showed an acceptable pharmacokinetic profile and sufficient brain exposure in rodents in order to characterize the compound in vivo. Hence, in a rodent model of learning and memory, 17 reversed delay-induced natural forgetting, suggesting a procognitive potential of 17.

Journal of Medicinal Chemistry published new progress about 55346-97-9. 55346-97-9 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 4,5-Difluoro-2-nitrophenol, and the molecular formula is C6H3F2NO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kirschenlohr, Heide L. published the artcileEstimation of systolic and diastolic free intracellular Ca²⁺ by titration of Ca²⁺ buffering in the ferret heart, COA of Formula: C6H3F2NO3, the publication is Biochemical Journal (2000), 346(2), 385-391, database is CAplus.

Spectroscopic Ca²⁺-indicators are thought to report values of free intracellular Ca²⁺ concentration ([Ca²⁺]_i) that may differ from unperturbed values because they add to the buffering capacity of the tissue. To check this for the heart we have synthesized a new ¹⁹F-labeled NMR Ca²⁺ indicator, 1,2-bis-[2-bis-(carboxymethyl)amino-4,5-difluorophenoxy]ethane (“4,5FBAPTA”), with a low affinity (K_d 2950 nM). The new indicator and four previously described ¹⁹F-NMR Ca²⁺ indicators 1,2-bis-[2-(1-carboxyethyl)(carboxymethyl)amino-5-fluorophenoxy]ethane (“DiMe-5FBAPTA”), 1,2-bis-[2-(1-carboxyethyl)(carboxymethyl)-amino-4-fluorophenoxy]ethane (“DiMe-4FBAPTA”), 1,2-bis-[2-bis(carboxymethyl)amino-5-fluorophenoxy]ethane (“5FBAPTA”) and 1,2-bis-[2-bis(carboxymethyl)amino-5-fluoro-4-methylphenoxy]ethane (“MFBAPTA”), with dissociation constants for Ca²⁺ ranging from 46 to 537 nM, have been used to measure [Ca²⁺]_i, over the range from less than 100 nM to more than 3 μM, in Langendorff-perfused ferret hearts (30°C, pH 7.4, paced at 1.0 Hz) by ¹⁹F-NMR spectroscopy. Loading hearts with indicators resulted in buffering of the Ca²⁺ transient. The measured end-diastolic and peak-systolic [Ca²⁺]_i were both pos. correlated with indicator K_d. The pos. correlations between indicator K_d and the measured end-diastolic and peak-systolic [Ca²⁺]_i were used to estimate the unperturbed end-diastolic and peak-systolic [Ca²⁺]_i by extrapolation to K_d = 0 (diastolic) and to K_d = ∞ (systolic) resp. The extrapolated values in the intact beating heart were 161 nM for end-diastolic [Ca²⁺]_i and 2650 nM for peak-systolic [Ca²⁺]_i, which agree well with values determined from single cells and muscle strips.

Biochemical Journal published new progress about 55346-97-9. 55346-97-9 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 4,5-Difluoro-2-nitrophenol, and the molecular formula is C6H3F2NO3, COA of Formula: C6H3F2NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shiley, R. H. published the artcileFungicidal activity of some fluoroaromatic compounds, Quality Control of 55346-97-9, the publication is Journal of Fluorine Chemistry (1975), 5(4), 371-6, database is CAplus.

Of 52 fluoroaromatic compounds tested (18 prepared) for their fungicidal activity against Stromatinia gladioli, Fusarium oxysporum gladioli, Curvularia trifolii gladioli, Thielaviopsis basicola, and Ceratocystis ulmi, I [327-91-3], II [38636-12-3], and III [327-92-4] were the most effective.

Journal of Fluorine Chemistry published new progress about 55346-97-9. 55346-97-9 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 4,5-Difluoro-2-nitrophenol, and the molecular formula is C3H5BN2O2, Quality Control of 55346-97-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts