Category: 108343-90-4

Related Products of 108343-90-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 108343-90-4, name is 2-Amino-2-(2-methoxyphenyl)ethanol, molecular formula is C9H13NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of HOBt (3.24 g, 23.9 mmol) and WSC (4.60 g, 23.9 mmol) in THF (40 mL) under nitrogen atmosphere, 36 (1.90 g, 11.4 mmol) and 18c (1.29 g, 7.4 mmol) were added. The reaction mixture was stirred at room temperature for 24 h and the solvent was evaporated under reduced pressure. The crude product was dissolved in ethyl acetate, the solution washed with NaHCO3, HCl 2 M and brine, dried over Na2SO4 and evaporated under reduced pressure to afford 37 as a white solid (2.33 g, 97%); mp 93-95 C. 1H NMR (CDCl3) delta: 7.64 (1H, d, J = 8.3 Hz), 7.21-7.43 (5H, m), 7.15 (1H, m), 6.29-7.03 (2H, m), 6.90 (1H, s), 5.51 (1H, m), 4.05 (3H, s), 3.93-4.03 (2H, m), 3.93 (3H, s). 13C NMR (DMSO-d6) delta: 162.1, 156.9, 138.9, 132.9, 129.4, 128.6, 127.6, 126.2, 124.0, 122.0, 120.8, 120.7, 111.3, 111.0, 105.1, 63.8, 56.0, 50.9. Anal. Calcd for C19H20N2O3: C, 70.35; H, 6.21; N, 8.64. Found: C, 70.30; H, 6.27; N, 8.60.

According to the analysis of related databases, 108343-90-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Cananzi, Salvatore; Merlini, Lucio; Artali, Roberto; Beretta, Giovanni Luca; Zaffaroni, Nadia; Dallavalle, Sabrina; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4971 – 4984;,
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Reference of 108343-90-4 , The common heterocyclic compound, 108343-90-4, name is 2-Amino-2-(2-methoxyphenyl)ethanol, molecular formula is C9H13NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 250-ml triple-neck flask, 4.2 g (25 mmol) of 2-amino-2-(2-methoxyphenyl)ethanol obtained previously and 2.5 g (25 mmol) of KHCO3 are solubilized in 40 ml of water. After 10 min of stirring, it cooled to 0 C. and 3.4 g (25 mmol) of K2CO3, are added and then 17 ml (32.6 mmol) of 20% phosgene in toluene are added dropwise. The medium is stirred at 0 C. for 6 h. The formation of a white product is observed, which is filtered and dried. 3.6 g (18.6 mmol) of 4-(2-methoxyphenyl)oxazolidin-2-one are recovered in the form of a white solid. Yield: 75% . 1H NMR (CDCl3) delta: 3.85 (s, 3H); 4.18 (dd, 1H, J=8.8 and 6.4 Hz); 4.80 (m, 1H); 5.25 (dd, 1H, J=8.6 and 6.4 Hz); 5.46 (is, 1H); 6.90 (m, 1H); 7.01 (m, 1H); 7.32 (m, 2H).

The synthetic route of 108343-90-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PIERRE FABRE MEDICAMENT; SOKOLOFF, Pierre; MAILLOS, Philippe; CUISIAT, Florence; VIDALUC, Jean-Louis; IMBERT, Thierry; US2015/336943; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts