Category: 2516-33-8

Chemistry is an experimental science, Name: Cyclopropylmethanol, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 2516-33-8, Name is Cyclopropylmethanol, molecular formula is C4H8O, belongs to alcohols-buliding-blocks compound. In a document, author is Roche, Ann.

Objective Older workers are increasingly prevalent in health and human services, including the alcohol and other drug (AOD) sector. Their turnover intentions have important implications for service system stability and retention. Methods Descriptive and regression analyses of survey data examined age-related differences (<50, >= 50 years old) in non-government workers’ demographic, health and professional profiles and predictors of turnover intention. Results Older workers (>= 50 years, n = 86) comprised one-third of this workforce. Compared to younger workers (n = 164), they experienced greater discrimination but higher work-life balance and work engagement. Turnover intention was predicted by job satisfaction, discrimination and work engagement. Conclusion Older workers’ well-being and workforce retention are essential for effective leadership, succession planning and service continuity. Their needs and retention motivations are identified. Age-specific support mechanisms, proactive retention and anti-discrimination strategies are identified priorities.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 2516-33-8, in my other articles. Name: Cyclopropylmethanol.

Reference:
Alcohol – Wikipedia,
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Synthetic Route of 2516-33-8 ,Some common heterocyclic compound, 2516-33-8, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirring solution/suspension comprised of N-hydroxyphthalimide (Aldrich, 57.15 g, 339.8 mmol), cyclopropanemethanol (Aldrich, 25.10 g, 341.1 mmol), and triphenylphosphine (“DEAD,” Aldrich, 91.0 g, 344 mmol) in 1.00 L of tetrahydrofuran under a nitrogen atmosphere and cooled to 6 C. (internal mixture temperature) with an ice-water bath was added diethyl azodicarboxylate (Aldrich, 56 ml, 356 mmol) dropwise over 20 minutes via addition funnel. The reaction mixture temperature was kept below 20 C. during the addition. Following addition of the DEAD, the cold bath was removed and the reaction mixture was stirred for 15 hours. The mixture was concentrated to a paste under reduced pressure. Chloroform (ca. 300 ml) was added and the mixture swirled to loosen all solids. Vacuum filtration removed the insolubles. The filtrate was likewise filtered to remove white precipitate that formed and to give a clear filtrate. Concentration under reduced pressure afforded a clear oil. Flash filtration through silica gel (100% chloroform) gave filtrates containing unseparated product. These filtrates were combined and concentrated under reduced pressure to afford 127.4 g of a clear oil. The oil was dissolved in absolute ethanol (400 ml) and the solution was refrigerated for two hours. A white crystalline solid had precipitated and was subsequently collected by vacuum filtration. The product was dried in the vacuum oven (60 C.) to afford 42.66 g (58%) of the desired material; m.p. 71-77 C.; 1H-NMR (400 MHz; CDCl3 signal offset to delta 6.96) delta 7.54-7.43 (m, 4H), 3.74 (d, 2H, J=7.6 Hz), 1.02-0.95 (m, 1H), 0.34-0.30 (m, 1H), 0.04-0.00 (m, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2516-33-8, Cyclopropylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Warner-Lambert Company; US7030119; (2006); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2516-33-8, name is Cyclopropylmethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2516-33-8

General procedure: To 259 mg (26.9 mmol) pyrimidin-5-ol (J. Chem. Soc. 1956, 2033) in 200 mL DMF are added 108 mg (26.9 mmol) sodium hydride (60% dispersion in mineral oil). The mixture is stirred for 20 mm at r.t.. After that time, 500 mg (22.4 mmol) 2-fluoro-4-iodopyridine are added and the mixture is stirred for 12 h at 80 C. Subsequently the mixture is poured into water and extracted with ethyl acetate (3x). The combined organic layers are washed with brine. After drying over sodium sulphate, the solvent is removed in vacuo and the residue is purified by column chromatography (silica gel; heptane/EtOAc, 100/0 – 40/60).C9H6IN3O (M = 299.1 g/mol)ESI-MS: 300 [M+H]+ Rt(HPLC) : 2.87 min (method C) For the example XXVIII.3 THF is used as solvent and the reaction mixture is stirred at r.t. over night.

With the rapid development of chemical substances, we look forward to future research findings about 2516-33-8.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; ROTH, Gerald Juergen; NOSSE, Bernd; HEINE, Niklas; WO2013/92616; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2516-33-8 ,Some common heterocyclic compound, 2516-33-8, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The gas-phase selective oxidation of alcohols on these catalysts with molecular oxygen was carried out on a fixed-bed quartz tube reactor (i.d., 16 mm) under atmospheric pressure as described previously [14,15,26,27]. Circular chips (16.1 mm diameter) of the microfibrous-structured Au/Ni-fiber catalysts were punched down from their large sheet sample and packed layer-up-layer into the tube reactor with total mass of 0.3 g. Note that the diameter of 0.1 mm larger than the i.d. of the tubular reactor was retained deliberately to avoid the appearance of the gap between the reactor wall and the edges of the catalyst chips thereby preventing the gas bypassing. Alcohols were fed continuously using a high-performance liquid pump, in parallel with O2 (oxidant) and N2 (diluted gas) feeding using the calibrated mass flow controllers, into the reactor heated to the desired reaction temperature. The organic phase of the liquid effluent was collected for analyzing by an HP 5890 gas chromatography-flame ionization detector (GC-FID) with a 60-m HP-5 ms capillary column. The gas-phase products such as H2, COx, and C1-C3 hydrocarbons were analyzed by an HP-5890 GC with thermal conductivity detector (TCD) and a 30-m AT-plot 300 capillary column. Reaction temperature, WHSV, and alcoholic hydroxyl (O2/ol) were varied in range from 220 to 380 C, 10 to 70 h-1, and 0.4 to 1.2, respectively. Prior to the reaction testing, as-prepared catalysts were all activated by performing the benzyl alcohol oxidation at a high temperature of 380 C for 1 h, using molar ratio of O2 to O2/ol = 0.6 and WHSV = 20 h-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2516-33-8, its application will become more common.

Reference:
Article; Zhao, Guofeng; Deng, Miaomiao; Jiang, Yifeng; Hu, Huanyun; Huang, Jun; Lu, Yong; Journal of Catalysis; vol. 301; (2013); p. 46 – 53;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2516-33-8, Cyclopropylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Cyclopropylmethanol, blongs to alcohols-buliding-blocks compound. Safety of Cyclopropylmethanol

To a 2 L flask was charged with cyclopropanemethanol (8A) (18 g, 250 mmol, 1 equiv), TEMPO (78 mg, 0.5 mmol) and CH2Cl2 (250 mL). The solution was cooled to 0 C, and a solution of KBr (2.99 g, 25 mmol, 0.1 equiv), NaHCO3 (52.5 g, 625 mmol, 2.5 equiv), and 10-13% NaOCl (150 mL, 313 mmol, 1.25 equiv) in H2O (80 mL) was then slowly added. After the resulting mixture was had been stirring at 0 C for 45 min, the two layers were separated. The aqueous layer was back extracted with CH2Cl2 (2 x 250 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated. The resulting residue was purified via shortpath distillation head under N2 (95-100 C) to give the corresponding aldehyde 8B (11. 02 g, 73%) as a colorless liquid.

The synthetic route of 2516-33-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Trost, Barry M.; Nguyen, Hien M.; Koradin, Christopher; Tetrahedron Letters; vol. 52; 17; (2011); p. 2033 – 2036;,
Alcohol – Wikipedia,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2516-33-8, name is Cyclopropylmethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Typical Procedure 6: To a mixture of 2-cyclopropyl-methanol (6.15 g) and DMF (12 mL) was added NaH (60% in mineral oil, 1.5 g) at 0 C. After stirring for 4 hours at RT, the mixture was diluted with DMF (5 mL) and 5-bromo-2-fluoro-pyridine (6.00 g) was slowly added keeping the reaction temperature below 30 C. After 30 minutes at RT, the mixture was heated to 130 C. for 1 hour by microwave irradiation. After cooling to RT, the mixture was diluted with EA and washed with water (3 times). The organic phase was dried (Na2SO4) and concentrated. The residue was purified by SGC to provide 5-bromo-2-cyclopropylmethoxy-pyridine. MS ESI+: m/z=228 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 2516-33-8.

Reference:
Patent; SANOFI; Schwink, Lothar; Buning, Christian; Glombik, Heiner; Poverlein, Christoph; Ritter, Kurt; Halland, Nis; Lohmann, Matthias; (52 pag.)US2018/237419; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2516-33-8, Cyclopropylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

General procedure: To a solution of (3,3-difluorocyclobutyl)methanol (4.0 g, 32.8 mmol) in dichloromethane (109 ml) at room temperature was added Dess-Martin Periodinane (16.7 g, 39.3 mmol). After 2 h, the reaction was diluted with two volumes of ether and treated with sodiumthiosulfate (32 g) in water (160 mL). After stirring at room temperature for 10 min, the layers were separated. The ethereal was washed with saturated sodium bicarbonate (2X), dried over magnesium sulfate, and filtered. The resulting solution was concentrated via distillation of the solvent through a short path distillation apparatus. The distillation was discontinued when 6.56 g remained in the boiling flask. Integration of the 1H NMR showed product as a 28.4 wt% solution in diethyl ether (1.86 g, 47% yield). The material was directly used without further concentration

The synthetic route of 2516-33-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Degnan, Andrew P.; Maxwell, Darrell; Balakrishnan, Anand; Brown, Jeffrey M.; Easton, Amy; Gulianello, Michael; Hanumegowda, Umesh; Hill-Drzewi, Melissa; Miller, Regina; Santone, Kenneth S.; Senapati, Arun; Shields, Eric E.; Sivarao, Digavalli V.; Westphal, Ryan; Whiterock, Valerie J.; Zhuo, Xiaoliang; Bronson, Joanne J.; Macor, John E.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 24; (2016); p. 5871 – 5876;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2516-33-8, name is Cyclopropylmethanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 2516-33-8

Intermediate 1:Preparation of cyclopropylmethyl 2,5-dioxopyrrolidin-l-yl carbonate. added bis(2,5-dioxopyrrolidin-l -yl) carbonate (7.1 g, 27.7 mmol) and triethylamine (5.8 mL, 41.6 mmol). The reaction was stirred overnight then quenched with saturated NaHC03 (aq.) and extracted with ethyl acetate (3 chi 50 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to provide the title compound as an amber oil: NMR (300 MHz, CDC13) delta 4.16 (d, J = 7.5 Hz, 2H), 2.84 (s, 4H), 1.26 (m, 1H), 0.70-0.64 (m, 2H), 0.40-0.35 (m, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 2516-33-8.

Reference:
Patent; MERCK SHARP & DOHME CORP.; EDMONDSON, Scott; GUO, Zhiqiang; GEISS, William, B.; WOOD, Harold, B.; STAMFORD, Andrew, W.; MILLER, Michael, W.; DEMONG, Duane, E.; MORRIELLO, Gregori, J.; ANAND, Rajan; COLANDREA, Vincent, J.; MACALA, Megan; MALETIC, Milana; ZHU, Cheng; ZHU, Yuping; SUN, Wanying; ZHAO, Kake; HUANG, Yong; HARRIS, Joel, M.; CHANG, Lehua; KAR, Nam Fung; HU, Zhiyong; WANG, Liping; WANG, Bowei; LIU, Ping; SZEWCZYK, Jason, W.; WO2012/138845; (2012); A1;,
Alcohol – Wikipedia,
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Application of 2516-33-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2516-33-8, name is Cyclopropylmethanol, molecular formula is C4H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step A: cyclopropylmethyl 2,5-dioxopyrrolidin-l-yl carbonate.To a stirred solution of cyclopropylmethanol (1.0 g, 13.8 mmol) in acetonitrile (15 mL) was added bis(2,5-dioxopyrrolidin-l-yl) carbonate (7.1 g, 27.7 mmol) and triethylamine (5.8 mL, 41.6 mmol). The reaction was stirred overnight, then quenched with saturated NaHC03 solution (aq.) and extracted with ethyl acetate (3 * 50 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to provide the title compound (3.2 g, quant.) as an amber oil: 1H NMR (300 MHz, CDC13) delta 4.16 (d, J= 7.5 Hz, 2H), 2.84 (s, 4H), 1.26 (m, 1H), 0.70- 0.64 (m, 2H), 0.40-0.35 (m, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2516-33-8, Cyclopropylmethanol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MILLER, Michael; STAMFORD, Andrew; BASU, Kallol; WOOD, Harold, B.; DEMONG, Duane; SUN, Wanying; GARFUNKLE, Joie; MOYES, Christopher; HU, Zhiyong; LIU, Ping; EDMONDSON, Scott, D.; DAI, Xing; DUBOIS, Byron Gabriel; WO2012/173917; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2516-33-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2516-33-8, name is Cyclopropylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of cyclopropanemethanol (1.00 g, 0.90 mL, 13.87 mmol) and pyridine (1.43 g, 1.45 mL, 18.03 mmol) in acetonitrile (80 mL) was added N,N’-disuccinimidyl carbonate (4.62 g, 18.03 mmol) in one portion and the solution was heated to 40 C. for 4 h. After cooling to room temperature, the solvent was evaporated to dryness and the residue was taken up in dichloromethane (150 mL), washed with saturated aqueous sodium bicarbonate (2×150 mL) and saturated brine (100 mL), dried (MgSO4) and concentrated to afford cyclopropanemethanol-(CO.N-hydroxysuccinimide) (2.93 g, 99%), as a colourless oil that was used without further purification.

According to the analysis of related databases, 2516-33-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SHIRE LLC; US2012/65152; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts