Category: 2516-33-8

Electric Literature of 2516-33-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2516-33-8, name is Cyclopropylmethanol, molecular formula is C4H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

b) 5-Bromo-6-cyclopropylmethoxy-pyridine-2-carboxylic acid Sodium hydride (4.83 g, 0.12 mol) was added into cyclopropanemethanol (CAN 2516-33- 8, 30 g) at 0 C and the mixture was stirred at 0 C for 1 h. Then to the mixture was added methyl 5-bromo-6-chloro-pyridine-2-carboxylic acid methyl ester (3 g, 12.75 mmol). The obtained solution was heated to 90 C for 2 h. Then the mixture was evaporated to dryness, the residue was dissolved in 40 mL of water, and adjusted to pH = 4 with hydrochloric acid (3 N), and extracted with ethyl acetate (3 x 30 mL). The combined organic layer was washed with water (2 x 30 mL) and brine (2 x 50 mL) then evaporated to dryness to obtain the product as a white solid (2.5 g, 76.7%); MS (EI): m/e = 272.0 [MH+] .

According to the analysis of related databases, 2516-33-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BENDELS, Stefanie; GRETHER, Uwe; KIMBARA, Atsushi; NETTEKOVEN, Matthias; ROEVER, Stephan; ROGERS-EVANS, Mark; SCHAFFTER, Ernst; SCHULZ-GASCH, Tanja; WO2014/86806; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2516-33-8, name is Cyclopropylmethanol, molecular formula is C4H8O, molecular weight is 72.1057, as common compound, the synthetic route is as follows.Safety of Cyclopropylmethanol

10062] Into a clean, dry reactor equipped with a stirrer and under nitrogen are successively loaded 4.63 kg of DMF (5.1 eqV) and then 4.53 kg of triphenylphosphite. 2.34 kg of bromine is then introduced while maintaining the temperature at less than 12 C. The stirring speed is regulated according to the fluidity of the reaction medium. When casting ends, a very thick medium with a yellow solid suspension is obtained.10063] The set point of the jacket is then adjusted to -12 C. and then 0.96 kg of cyclopropylmethanol is introduced in such a way as not to exceed a temperature of -5 C. On completion of the addition the whole is allowed to return slowly to room temperature. The set point of the jacket is then adjusted to 64 C. for distillation, which is carried out at a pressure of 13 mbar by collecting the first 24 to 30 C. fraction at the top of the colunm, then the second 30 to 40 C. fraction (partial reflux). Two fractions, Fl (1.38 kg) and F2 (293 g), are collected. The two fractions, after washing with carbonated water and then drying by means of CaC12, lead to a final product 2a (mass 1.316 kg) having a GC relative purity of 98.7% with a yield of 73%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2516-33-8, Cyclopropylmethanol, and friends who are interested can also refer to it.

Reference:
Patent; MELCHIOR MATERIAL AND LIFE SCIENCE FRANCE; GUERRET, Olivier; (6 pag.)US2016/355452; (2016); A1;,
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Electric Literature of 2516-33-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2516-33-8 as follows.

EXAMPLE 3 Cyclopropanecarboxyaldehyde, 2-(1-nonenyl)-,(Z)- A solution of cyclopropanemethanol, 2-(1-nonenyl)-, (21.6 g, 0.11 moles) in methylene chloride (25 ml) is added dropwise to a solution of pyridinium dichromate (79.8 g, 0.208 moles) in methylene chloride (200 ml) at room temperature under nitrogen. The reaction mixture is stirred overnight. The mixture is diluted with ether (500 ml), filtered through celite and then through a short column of silica gel. The solvents are stripped from the filtrate to give the crude product (21.6 g). Distillation at reduced pressure gives the product as a clear colorless oil (14.8 g, 69%), b.p. 81-86 C. (0.06 mm).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2516-33-8, its application will become more common.

Reference:
Patent; Warner-Lambert Company; US4562006; (1985); A;,
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Synthetic Route of 2516-33-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2516-33-8, name is Cyclopropylmethanol, molecular formula is C4H8O, molecular weight is 72.1057, as common compound, the synthetic route is as follows.

5-Bromo-2-cyclopropylmethoxy-pyridine 0.49 g (6.82 mmol) cyclopropane methanol in 10 mL THF are charged with 0.42 g (11.4 mmol) NaH and the reaction mixture is stirred at r.t. for 20 min. Then 1.00 g (5.68 mmol) 5-bromo-2-fluoropyridine are added and the mixture is stirred at r.t. over night. The reaction is quenched by the addition of water and extracted with EtOAc. The organic layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by HPLC (MeOH/H2O/FA). C9H10BrNO (M=228.1 g/mol) ESI-MS: 228/229 [M+H]+Rt(HPLC):1.14 min (method C)

The chemical industry reduces the impact on the environment during synthesis 2516-33-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; US2014/213568; (2014); A1;,
Alcohol – Wikipedia,
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Reference of 2516-33-8, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 2516-33-8, Name is Cyclopropylmethanol, SMILES is OCC1CC1, belongs to alcohols-buliding-blocks compound. In a article, author is Morellato, Agustin E., introduce new discover of the category.

The toxic side of one-carbon metabolism and epigenetics

One-carbon metabolism is a central metabolic hub that provides one-carbon units for essential biosynthetic reactions and for writing epigenetics marks. The leading role in this hub is performed by the one-carbon carrier tetrahydrofolate (THF), which accepts formaldehyde usually from serine generating one-carbon THF intermediates in a set of reactions known as the folate or one-carbon cycle. THF derivatives can feed one-carbon units into purine and thymidine synthesis, and into the methionine cycle that produces the universal methyl donor S-adenosylmethionine (AdoMet). AdoMet delivers methyl groups for epigenetic methylations and it is metabolized to homocysteine (Hcy), which can enter the transsulfuration pathway for the production of cysteine and lastly glutathione (GSH), the main cellular antioxidant. This vital role of THF comes to an expense. THF and other folate derivatives are susceptible to oxidative breakdown releasing formaldehyde, which can damage DNA-a consequence prevented by the Fanconi Anaemia DNA repair pathway. Epigenetic demethylations catalysed by lysine-specific demethylases (LSD) and Jumonji histone demethylases can also release formaldehyde, constituting a potential threat for genome integrity. In mammals, the toxicity of formaldehyde is limited by a metabolic route centred on the enzyme alcohol dehydrogenase 5 (ADH5/GSNOR), which oxidizes formaldehyde conjugated to GSH, lastly generating formate. Remarkably, this formate can be a significant source of one-carbon units, thus defining a formaldehyde cycle that likely restricts the toxicity of one-carbon metabolism and epigenetic demethylations. This work describes recent advances in one-carbon metabolism and epigenetics, focusing on the steps that involve formaldehyde flux and that might lead to cytotoxicity affecting human health.

Reference of 2516-33-8, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 2516-33-8 is helpful to your research.

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Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Settier-Ramirez, Laura, once mentioned the application of 2516-33-8, Name is Cyclopropylmethanol, molecular formula is C4H8O, molecular weight is 72.1057, MDL number is MFCD00001309, category is alcohols-buliding-blocks. Now introduce a scientific discovery about this category, HPLC of Formula: C4H8O.

Evaluation of Lactococcus lactis subsp. lactis as protective culture for active packaging of non-fermented foods: Creamy mushroom soup and sliced cooked ham

An innovative edible coating, made from food grade polyvinyl alcohol (PVOH) and gelatin hydrolysates (HGel), was evaluated as a carrier of Lactococcus lactis acting as anti-listeria protective culture for refrigerated foods. The coating was applied on a compostable polylactic acid film surface and its anti-listeria activity was evaluated at 4 degrees C in a liquid culture medium and in solid agar, inoculated with Listeria monocytogenes. The best results were obtained in agar, exerting a bactericide effect, whereas in the liquid medium the coating had bacteriostatic behaviour. Furthermore, the active coating was applied to the surface of bags or separator liners made from polylactic acid. Its effectivity was evaluated with creamy mushroom soup (bags) and sliced cooked ham (separator liners) previously inoculated with L. monocytogenes and stored at 4 degrees C. Results showed that the coating was effective at inhibiting pathogen growth; however, it did not display a bactericide effect in the foods. In addition, L. lactis remained viable in all experiments conducted in this study. The acidification produced by L. lactis, because of the generation of organic acids, did not compromise the sensory properties of the sliced cooked ham after 16 days of refrigerated storage. In contrast, consumers perceived a mushroom soup acidification because of a greater decrease in pH than the sliced cooked ham. This study demonstrates that a food grade polyvinyl alcohol polymer blended with gelatin hydrolysates can be used as a carrier of protective cultures of L. lactis to increase the microbiological safety of refrigerated foods.

If you are interested in 2516-33-8, you can contact me at any time and look forward to more communication. HPLC of Formula: C4H8O.

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Reference of 2516-33-8, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 2516-33-8, Name is Cyclopropylmethanol, SMILES is OCC1CC1, belongs to alcohols-buliding-blocks compound. In a article, author is Nakamura, Jun, introduce new discover of the category.

An unexpected butadiene diolepoxide-mediated genotoxicity implies alternative mechanism for 1,3-butadiene carcinogenicity

1,3-Butadiene (BD) is abundant in combustion products such as cigarette smoke. While BD has been classified as a known human carcinogen, a long-standing question is the identity of the ultimate carcinogenic metabolite in humans. We hypothesize that 3,4-epoxybutane-1,2-diol (EBD) may play a critical role in human carcinogenesis due to its high bioavailability. We utilized a differential toxicity assay for BD metabolites and newly synthesized EBD analogs in a series of isogenic chicken cells lacking specific DNA repair proteins to address the mode of action of BD genotoxicity and infer a mode of action. Surprisingly, as with the diepoxide 1,2:3,4-diepoxybutane (DEB), the monoepoxide EBD showed remarkable toxicity to cells deficient in Fanconi anemia (FANC) genes. This observation suggests that EBD may be transformed into a bifunctional metabolite and forms interstrand cross-links. EBD and its analog with a hydroxy substituent at C1 were found to be highly toxic to FANCD2-deficient chicken and human cells. The Results suggest that EBD may be transformed to a bifunctional epoxy aldehyde, perhaps by alcohol dehydrogenase, to which the observed FANC sensitivity could be attributed. The implications of this study are very important in considering mechanisms by which EBD may cause leukemia and lymphoma in humans exposed to BD. (C) 2020 Elsevier Ltd. All rights reserved.

Reference of 2516-33-8, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 2516-33-8.

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Related Products of 2516-33-8, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 2516-33-8, Name is Cyclopropylmethanol, SMILES is OCC1CC1, belongs to alcohols-buliding-blocks compound. In a article, author is Capriolo, G., introduce new discover of the category.

High-temperature oxidation of propanol isomers in the mixtures with N2O at high Ar dilution conditions

This work provides, for the first time, new information regarding the kinetics interaction between N2O and propyl alcohol isomers. To this end, the formation and consumption of atomic oxygen were measured behind the reflected shock waves using Atomic Resonance Absorption Spectroscopy (ARAS) technique for 1-10 ppm n- i- propanol + 10 ppm N2O + Ar mixtures, at 2-3 bar and over a wide temperature range of 1700-3200 K. The Konnov and POLIMI detailed combustion mechanisms were assessed against experimental data and also employed to study the main reactions influencing the oxidation dynamics of fuel mixtures under the investigated conditions. The study highlighted a certain difficulty by the models tested in predicting the formation of atomic oxygen at T < 2000 K. The rate of production and the sensitivity analysis was performed with the attempt to identify the most important reactions involved in the process oxidation for future kinetic model refinements. Related Products of 2516-33-8, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 2516-33-8.

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Alcohol – Wikipedia,
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Synthetic Route of 2516-33-8, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 2516-33-8, Name is Cyclopropylmethanol, SMILES is OCC1CC1, belongs to alcohols-buliding-blocks compound. In a article, author is Bollen, Zoe, introduce new discover of the category.

Prior drinking motives predict alcohol consumption during the COVID-19 lockdown: A cross-sectional online survey among Belgian college students

The global outbreak of coronavirus disease 2019 (COVID-19) and the resulting lockdown measures have raised concerns regarding their effect on alcohol consumption. We investigated alcohol use during lockdown in a population of college students, usually characterized by social and heavy drinking. We also tested the predictive role of pre-lockdown drinking motives on alcohol consumption during lockdown. We collected data from 1951 French-speaking Belgian students during the lockdown period (April 1st – May 3rd, 2020) through a crosssectional online survey. Participants self-reported their daily alcohol consumption (1) during a typical week in normal circumstances (i.e., before lockdown), and (2) since lockdown onset. We also assessed drinking motives and severity of alcohol use before lockdown. Our findings showed that 68.2% of the sample reported a lower alcohol consumption during lockdown compared to before lockdown, 17.2% conversely reporting a higher consumption. Enhancement, social and coping motives were all associated with heavy drinking before lockdown. Enhancement and social motives predicted lower alcohol consumption during lockdown among heavy drinkers. Conversely, coping motives, as well as social motives among low drinkers, predicted higher consumption during lockdown. Conformity motives, as well as enhancement motives among low and moderate drinkers, did not predict alcohol consumption before or during lockdown. Overall, several pre-lockdown drinking motives reliably predicted alcohol consumption during lockdown and could thus be used to identify at-risk populations and to tailor intervention programs on alcohol misuse during sanitary crises.

Synthetic Route of 2516-33-8, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 2516-33-8 is helpful to your research.

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2516-33-8, Name is Cyclopropylmethanol, molecular formula is C4H8O, belongs to alcohols-buliding-blocks compound, is a common compound. In a patnet, author is Xiang, Aimin, once mentioned the new application about 2516-33-8, SDS of cas: 2516-33-8.

Multifunctional nucleating agents with simultaneous plasticizing, solubilizing, nucleating and their effect on polyvinyl alcohol foams

Currently, preparing microcellular polymer foams by supercritical CO2(Sc-CO2) is a newly trend and challenge. The main limitation of Sc-CO2 used in microcellular foaming industry is its solubility. In this paper, four kinds of amines (formamide, ethylenediamine, polyamide dendrimer (PAMAM) and polyhedral oligomeric silsesquioxane (POSS)) were introduced into polyvinyl alcohol (PVA) to improve the foaming behaviors. The results of differential scanning calorimetry showed that formamide and POSS could plasticize PVA to a certain extent. Through SEM analysis, formamide and ethylenediamine has a nucleating effect and improves the foaming effect. Furthermore, the content of formamide has a great influence on the foaming behavior of PVA. TG-IR analysis showed that -NH2 can react with CO2 to form -HNCOO- at normal temperature and pressure, which contributed to the diffusion of CO2 and improved the uniformity of cell size. With increasing formamide content, the cell density increased from 3.22 x 10(9) cm(-3) to 1.79 x 10(10) cm(-3).

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