Application of 2516-33-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2516-33-8, name is Cyclopropylmethanol, molecular formula is C4H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step A: cyclopropylmethyl 2,5-dioxopyrrolidin-l-yl carbonate.To a stirred solution of cyclopropylmethanol (1.0 g, 13.8 mmol) in acetonitrile (15 mL) was added bis(2,5-dioxopyrrolidin-l-yl) carbonate (7.1 g, 27.7 mmol) and triethylamine (5.8 mL, 41.6 mmol). The reaction was stirred overnight, then quenched with saturated NaHC03 solution (aq.) and extracted with ethyl acetate (3 * 50 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to provide the title compound (3.2 g, quant.) as an amber oil: 1H NMR (300 MHz, CDC13) delta 4.16 (d, J= 7.5 Hz, 2H), 2.84 (s, 4H), 1.26 (m, 1H), 0.70- 0.64 (m, 2H), 0.40-0.35 (m, 2H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2516-33-8, Cyclopropylmethanol.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MILLER, Michael; STAMFORD, Andrew; BASU, Kallol; WOOD, Harold, B.; DEMONG, Duane; SUN, Wanying; GARFUNKLE, Joie; MOYES, Christopher; HU, Zhiyong; LIU, Ping; EDMONDSON, Scott, D.; DAI, Xing; DUBOIS, Byron Gabriel; WO2012/173917; (2012); A1;,
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